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Long-term diuretic medication is an independent predictor of posthepatectomy liver failure

Background - Posthepatectomy liver failure (PHLF) is the most fatal complication after liver resection, particularly in patients with comorbidities. This study aimed to assess the effect of long-term medication on PHLF incidence after open liver resections. - Methods - A retrospective analysis of 68...

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Hauptverfasser: Betzler, Alexander (VerfasserIn) , Betzler, Johanna (VerfasserIn) , Bogner, Andreas (VerfasserIn) , Walther, Elene (VerfasserIn) , Rahbari, Mohammad (VerfasserIn) , Reissfelder, Christoph (VerfasserIn) , Riediger, Carina (VerfasserIn) , Weitz, Jürgen (VerfasserIn) , Rahbari, Nuh N. (VerfasserIn) , Birgin, Emrullah (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: May 2025
In: Journal of gastrointestinal surgery
Year: 2025, Jahrgang: 29, Heft: 5, Pages: 1-6
ISSN:1873-4626
DOI:10.1016/j.gassur.2025.102035
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.gassur.2025.102035
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1091255X25000940
Volltext
Verfasserangaben:Alexander Betzler, Johanna Betzler, Andreas Bogner, Elene Walther, Mohammad Rahbari, Christoph Reissfelder, Carina Riediger, Jürgen Weitz, Nuh N. Rahbari, Emrullah Birgin
Beschreibung
Zusammenfassung:Background - Posthepatectomy liver failure (PHLF) is the most fatal complication after liver resection, particularly in patients with comorbidities. This study aimed to assess the effect of long-term medication on PHLF incidence after open liver resections. - Methods - A retrospective analysis of 682 patients who underwent elective open hepatectomies between 2008 and 2015 at 2 academic centers was performed. Preoperative, intraoperative, and postoperative data were collected, including long-term medication. The risk factors for the development of PHLF and other postoperative complications were evaluated using univariate and multivariate logistic regression analyses. - Results - PHLF occurred in 81 patients (11.9%), with a higher incidence in patients taking diuretics as long-term medication than in those not taking diuretics (17.7% vs 5.3%, respectively; P <.001). Diuretic use was identified as a strong independent risk factor for PHLF (odds ratio [OR], 3.8 [95% CI, 2.1-7.0]; P <.001), alongside liver cirrhosis (OR, 3.8 [95% CI, 1.9-7.6]; P <.001), primary liver malignancies (OR, 3.8 [95% CI, 1.6-9.3]; P <.001), major hepatectomies (OR, 3.1 [95% CI, 1.7-5.7]; P <.001), and long operating time (OR, 4.2 [95% CI, 2.4-7.2]; P <.001). Patients with long-term diuretic intake were older, had higher body mass indices, and had more comorbidities, including liver cirrhosis. - Conclusion - Long-term diuretic use is associated with a significantly increased risk of PHLF after open hepatectomy.
Beschreibung:Online verfügbar: 26. März 2025, Artikelversion: 4. April 2025
Gesehen am 12.06.2025
Beschreibung:Online Resource
ISSN:1873-4626
DOI:10.1016/j.gassur.2025.102035

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