Long-term diuretic medication is an independent predictor of posthepatectomy liver failure
Background - Posthepatectomy liver failure (PHLF) is the most fatal complication after liver resection, particularly in patients with comorbidities. This study aimed to assess the effect of long-term medication on PHLF incidence after open liver resections. - Methods - A retrospective analysis of 68...
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| Main Authors: | , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
May 2025
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| In: |
Journal of gastrointestinal surgery
Year: 2025, Volume: 29, Issue: 5, Pages: 1-6 |
| ISSN: | 1873-4626 |
| DOI: | 10.1016/j.gassur.2025.102035 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.gassur.2025.102035 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1091255X25000940 
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| Author Notes: | Alexander Betzler, Johanna Betzler, Andreas Bogner, Elene Walther, Mohammad Rahbari, Christoph Reissfelder, Carina Riediger, Jürgen Weitz, Nuh N. Rahbari, Emrullah Birgin |
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| 245 | 1 | 0 | |a Long-term diuretic medication is an independent predictor of posthepatectomy liver failure |c Alexander Betzler, Johanna Betzler, Andreas Bogner, Elene Walther, Mohammad Rahbari, Christoph Reissfelder, Carina Riediger, Jürgen Weitz, Nuh N. Rahbari, Emrullah Birgin |
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| 520 | |a Background - Posthepatectomy liver failure (PHLF) is the most fatal complication after liver resection, particularly in patients with comorbidities. This study aimed to assess the effect of long-term medication on PHLF incidence after open liver resections. - Methods - A retrospective analysis of 682 patients who underwent elective open hepatectomies between 2008 and 2015 at 2 academic centers was performed. Preoperative, intraoperative, and postoperative data were collected, including long-term medication. The risk factors for the development of PHLF and other postoperative complications were evaluated using univariate and multivariate logistic regression analyses. - Results - PHLF occurred in 81 patients (11.9%), with a higher incidence in patients taking diuretics as long-term medication than in those not taking diuretics (17.7% vs 5.3%, respectively; P <.001). Diuretic use was identified as a strong independent risk factor for PHLF (odds ratio [OR], 3.8 [95% CI, 2.1-7.0]; P <.001), alongside liver cirrhosis (OR, 3.8 [95% CI, 1.9-7.6]; P <.001), primary liver malignancies (OR, 3.8 [95% CI, 1.6-9.3]; P <.001), major hepatectomies (OR, 3.1 [95% CI, 1.7-5.7]; P <.001), and long operating time (OR, 4.2 [95% CI, 2.4-7.2]; P <.001). Patients with long-term diuretic intake were older, had higher body mass indices, and had more comorbidities, including liver cirrhosis. - Conclusion - Long-term diuretic use is associated with a significantly increased risk of PHLF after open hepatectomy. | ||
| 650 | 4 | |a Comedication | |
| 650 | 4 | |a Hepatectomy | |
| 650 | 4 | |a International Study Group of Liver Surgery | |
| 650 | 4 | |a Liver insufficiency | |
| 650 | 4 | |a Multimorbidity | |
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