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Intranasal oxytocin blunts amygdala response to negative affective stimuli in males and females with alcohol use disorder: a randomized controlled cross-over trial

Negative affect plays a prominent role in the maintenance of alcohol use disorder (AUD) and has been identified as a risk factor for relapse to alcohol. To date, however, treatment options that target negative affective states and consecutive relapse risk in AUD are insufficient. Oxytocin (OXY) migh...

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Main Authors: Vetter, Sina (Author) , Schnabel, Sophia (Author) , Reichl, Matthias (Author) , Sirignano, Lea (Author) , Grinevich, Valéry (Author) , Koopmann, Anne (Author) , Spanagel, Rainer (Author) , Kiefer, Falk (Author) , Sommer, Wolfgang H. (Author) , Bach, Patrick (Author)
Format: Article (Journal)
Language:English
Published: 31 March 2025
In: Psychopharmacology
Year: 2025, Volume: 242, Pages: 1995-2007
ISSN:1432-2072
DOI:10.1007/s00213-025-06779-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00213-025-06779-x
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Author Notes:Sina Vetter, Sophia Schnabel, Matthias Reichl, Lea Sirignano, Valery Grinevich, Anne Koopmann, Rainer Spanagel, Falk Kiefer, Wolfgang Sommer, Patrick Bach
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Summary:Negative affect plays a prominent role in the maintenance of alcohol use disorder (AUD) and has been identified as a risk factor for relapse to alcohol. To date, however, treatment options that target negative affective states and consecutive relapse risk in AUD are insufficient. Oxytocin (OXY) might be a promising approach for addressing negative affective states and resulting motivation to use alcohol.
Item Description:Gesehen am 17.06.2025
Physical Description:Online Resource
ISSN:1432-2072
DOI:10.1007/s00213-025-06779-x

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