Notch signaling mediates between two pattern-forming processes during head regeneration in Hydra
Hydra head regeneration consists of hypostome/organizer and tentacle development, and involves Notch and Wnt/β-catenin signaling. Notch inhibition blocks hypostome/organizer regeneration, but not the appearance of the tentacle tissue. β-Catenin inhibition blocks tentacle, but not hypostome/organizer...
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| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
January 2025
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| In: |
Life science alliance
Year: 2025, Jahrgang: 8, Heft: 1, Pages: 1-18 |
| ISSN: | 2575-1077 |
| DOI: | 10.26508/lsa.202403054 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.26508/lsa.202403054 Verlag, lizenzpflichtig, Volltext: https://www.life-science-alliance.org/content/8/1/e202403054 
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| Verfasserangaben: | Mona Steichele, Lara Sauermann, Qin Pan, Jasmin Moneer, Alexandra de la Porte, Martin Heß, Moritz Mercker, Catharina Strube, Heinrich Flaswinkel, Marcell Jenewein, Angelika Böttger |
MARC
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| 245 | 1 | 0 | |a Notch signaling mediates between two pattern-forming processes during head regeneration in Hydra |c Mona Steichele, Lara Sauermann, Qin Pan, Jasmin Moneer, Alexandra de la Porte, Martin Heß, Moritz Mercker, Catharina Strube, Heinrich Flaswinkel, Marcell Jenewein, Angelika Böttger |
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| 520 | |a Hydra head regeneration consists of hypostome/organizer and tentacle development, and involves Notch and Wnt/β-catenin signaling. Notch inhibition blocks hypostome/organizer regeneration, but not the appearance of the tentacle tissue. β-Catenin inhibition blocks tentacle, but not hypostome/organizer regeneration. Gene expression analyses during head regeneration revealed the Notch-promoting expression of HyWnt3, HyBMP2/4, and the transcriptional repressor genes CnGsc, Sp5, and HyHes, while blocking HyBMP5/8b and the c-fos-related gene HyKayak. β-Catenin promotes the expression of the tentacle specification factor HyAlx, but not of HyWnt3. This suggests HyWnt3 and HyBMP4 as parts of a hypostome/organizer gene module, and BMP5/8, HyAlx, and β-catenin as parts of a tentacle gene module. Notch then functions as an inhibitor of tentacle production to allow regeneration of a hypostome/head organizer. HyKayak is a candidate target gene for HvNotch-induced repressor genes. Inhibiting HyKayak attenuated the expression of HyWnt3. Polyps of Craspedacusta do not have tentacles and thus after head removal only regenerate a hypostome structure. Notch signaling was not needed for head regeneration in Craspedacusta, corroborating the idea of its requirement during Hydra head regeneration to harmonize two co-operating pattern-forming processes. | ||
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