Next-generation multitarget stool DNA vs fecal immunochemical test in colorectal cancer screening
Fecal immunochemical tests (FITs) are the most widely used noninvasive colorectal cancer (CRC) screening tests. In 2014, a US/Canadian screening study reported higher sensitivity of a multitarget stool DNA test (MSDT), which combined fecal hemoglobin measurement with molecular DNA markers, compared...
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| Main Authors: | , , , , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
January 2025
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| In: |
JAMA internal medicine
Year: 2025, Volume: 185, Issue: 1, Pages: 110-112 |
| ISSN: | 2168-6114 |
| DOI: | 10.1001/jamainternmed.2024.6149 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1001/jamainternmed.2024.6149
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| Author Notes: | Teresa Seum, MSc, Tobias Niedermaier, PhD, Thomas Heisser, PhD, Michael Hoffmeister, PhD, Hermann Brenner, MD, MPH |
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| 520 | |a Fecal immunochemical tests (FITs) are the most widely used noninvasive colorectal cancer (CRC) screening tests. In 2014, a US/Canadian screening study reported higher sensitivity of a multitarget stool DNA test (MSDT), which combined fecal hemoglobin measurement with molecular DNA markers, compared with a commercial FIT. However, this increase in sensitivity was accompanied by a substantial loss of specificity. Despite 20-fold higher per-sample costs, use of MSDT-based screening strongly increased in the US in recent years. Recently, Imperiale et al evaluated diagnostic performance of a next-generation MSDT (NG-MSDT) in another screening colonoscopy cohort (BLUE-C study). Sensitivity was higher than that of a commercial FIT, although again specificity was lower. It was previously shown that lowering the positivity threshold of a commercial quantitative FIT could enhance diagnostic performance to be comparable to a multitarget stool ribonucleic acid (RNA) test, prompting an evaluation of whether the same approach could yield similar outcomes with the NG-MSDT. | ||
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