Cardiomyocyte-derived fibrosis as driver of cardiomyopathy: invited editorial
This editorial refers to ‘Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition’, by L.T. Timmer et al., https://doi.org/10.1093/cvr/cvaf021.Cardiac fibrosis describes pathological deposition of extracellular matrix (ECM),...
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| Main Authors: | , |
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| Format: | Article (Journal) Editorial |
| Language: | English |
| Published: |
March 2025
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| In: |
Cardiovascular research
Year: 2025, Volume: 121, Issue: 4, Pages: 528-529 |
| ISSN: | 1755-3245 |
| DOI: | 10.1093/cvr/cvaf025 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1093/cvr/cvaf025 Verlag, kostenfrei, Volltext: https://academic.oup.com/cardiovascres/article/121/4/528/8045731 
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| Author Notes: | Abel Martin-Garrido and Joerg Heineke |
| Summary: | This editorial refers to ‘Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition’, by L.T. Timmer et al., https://doi.org/10.1093/cvr/cvaf021.Cardiac fibrosis describes pathological deposition of extracellular matrix (ECM), which can either be the consequence of cardiomyocyte death in ‘replacement fibrosis’ or emerge as ‘reactive fibrosis’ during mechanical or metabolic overload in the absence of significant cardiomyocyte death. Excessive fibrosis and its chronification inevitably lead the progression of heart failure, mainly due to stiffening of the myocardium and predisposition to lethal arrhythmia. To identify new therapeutic strategies, underlying mechanisms and cell types need to be deciphered by basic research. |
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| Item Description: | Online veröffentlicht: 28. Februar 2025 Gesehen am 07.07.2025 |
| Physical Description: | Online Resource |
| ISSN: | 1755-3245 |
| DOI: | 10.1093/cvr/cvaf025 |