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Management of immune checkpoint inhibitor-associated toxicities in older adults with cancer: recommendations from the International Society of Geriatric Oncology (SIOG) : policy review

Immune checkpoint inhibitors (ICIs) have substantially advanced the treatment landscape for a wide variety of malignancies. Older adults represent a large and rapidly growing demographic, among whom ICIs are widely prescribed. Management of ICI-associated toxicity among older adults, particularly in...

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Main Authors: Mac Eochagain, Colm (Author) , Neuendorff, Nina Rosa (Author) , Gente, Karolina (Author) , Leipe, Jan (Author) , Verhaert, Marthe (Author) , Sam, Christine (Author) , de Glas, Nienke (Author) , Kadambi, Sindhuja (Author) , Canin, Beverly (Author) , Gomes, Fabio (Author) , Decoster, Lore (Author) , Korc-Grodzicki, Beatriz (Author) , Rostoft, Siri (Author) , Battisti, Nicolò Matteo Luca (Author) , Wildiers, Hans (Author)
Format: Article (Journal)
Language:English
Published: February 2025
In: The lancet. Oncology
Year: 2025, Volume: 26, Issue: 2, Pages: 90-102
ISSN:1474-5488
DOI:10.1016/S1470-2045(24)00404-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S1470-2045(24)00404-2
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1470204524004042
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Author Notes:Colm Mac Eochagain, Nina Rosa Neuendorff, Karolina Gente, Jan Leipe, Marthe Verhaert, Christine Sam, Nienke de Glas, Sindhuja Kadambi, Beverly Canin, Fabio Gomes, Lore Decoster, Beatriz Korc-Grodzicki, Siri Rostoft, Nicolò Matteo Luca Battisti, Hans Wildiers
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Summary:Immune checkpoint inhibitors (ICIs) have substantially advanced the treatment landscape for a wide variety of malignancies. Older adults represent a large and rapidly growing demographic, among whom ICIs are widely prescribed. Management of ICI-associated toxicity among older adults, particularly in the presence of frailty and comorbidity, poses unique challenges. In this Policy Review, developed by the International Society of Geriatric Oncology (SIOG), we offer an evidence-based framework for health-care providers, caregivers, and policy makers for treating older adults with ICIs, focusing on unique considerations for this population that are not adequately addressed by existing guidelines, and expanding them to encompass geriatric oncology principles.
Item Description:Gesehen am 15.07.2025
Online verfügbar: 3. Februar 2025, Artikelversion: 3. Februar 2025
Physical Description:Online Resource
ISSN:1474-5488
DOI:10.1016/S1470-2045(24)00404-2

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