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Intrinsic and extrinsic contributors to the cardiac benefits of exercise

Among its many cardiovascular benefits, exercise training improves heart function and protects the heart against age-related decline, pathological stress, and injury. Here, we focus on cardiac benefits with an emphasis on more recent updates to our understanding. While the cardiomyocyte continues to...

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Main Authors: Hastings, Margaret H. (Author) , Castro, Claire (Author) , Freeman, Rebecca (Author) , Abdul Kadir, Azrul (Author) , Lerchenmüller, Carolin (Author) , Li, Haobo (Author) , Rhee, James (Author) , Roh, Jason D. (Author) , Roh, Kangsan (Author) , Singh, Anand P. (Author) , Wu, Chao (Author) , Xia, Peng (Author) , Zhou, Qiulian (Author) , Xiao, Junjie (Author) , Rosenzweig, Anthony (Author)
Format: Article (Journal)
Language:English
Published: April 2024
In: JACC Basic to translational science
Year: 2024, Volume: 9, Issue: 4, Pages: 535-552
ISSN:2452-302X
DOI:10.1016/j.jacbts.2023.07.011
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jacbts.2023.07.011
Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2452302X23002942
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Author Notes:Margaret H. Hastings, PHD, Claire Castro, PHD, Rebecca Freeman, BA, Azrul Abdul Kadir, PHD, Carolin Lerchenmüller, MD, Haobo Li, PHD,James Rhee, MD, PHD, Jason D. Roh, MD, MHS, Kangsan Roh, PHD, Anand P. Singh, PHD, Chao Wu, MD, PHD, Peng Xia, PHD, Qiulian Zhou, PHD, Junjie Xiao, MD, PHD, Anthony Rosenzweig, MD
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Summary:Among its many cardiovascular benefits, exercise training improves heart function and protects the heart against age-related decline, pathological stress, and injury. Here, we focus on cardiac benefits with an emphasis on more recent updates to our understanding. While the cardiomyocyte continues to play a central role as both a target and effector of exercise’s benefits, there is a growing recognition of the important roles of other, noncardiomyocyte lineages and pathways, including some that lie outside the heart itself. We review what is known about mediators of exercise’s benefits—both those intrinsic to the heart (at the level of cardiomyocytes, fibroblasts, or vascular cells) and those that are systemic (including metabolism, inflammation, the microbiome, and aging)—highlighting what is known about the molecular mechanisms responsible.
Item Description:Online verfügbar: 18. Oktober 2023, Artikelversion: 22. April 2024
Gesehen am 16.07.2025
Physical Description:Online Resource
ISSN:2452-302X
DOI:10.1016/j.jacbts.2023.07.011

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