T cell awareness of paternal alloantigens during pregnancy
During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reacti...
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| Hauptverfasser: | , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 27, 1995
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| In: |
Science
Year: 1995, Jahrgang: 270, Heft: 5236, Pages: 630-633 |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.270.5236.630 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.270.5236.630 Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.270.5236.630 
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| Verfasserangaben: | Anna Tafuri, Judith Alferink, Peter Möller, Günter J. Hämmerling, Bernd Arnold |
| Zusammenfassung: | During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus had reduced numbers of Kb-reactive T cells and accepted Kb-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens. |
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| Beschreibung: | Gesehen am 17.07.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1095-9203 |
| DOI: | 10.1126/science.270.5236.630 |