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T cell awareness of paternal alloantigens during pregnancy

During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reacti...

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Bibliographic Details
Main Authors: Tafuri, Anna (Author) , Alferink, Judith (Author) , Möller, Peter (Author) , Hämmerling, Günter J. (Author) , Arnold, Bernd (Author)
Format: Article (Journal)
Language:English
Published: October 27, 1995
In: Science
Year: 1995, Volume: 270, Issue: 5236, Pages: 630-633
ISSN:1095-9203
DOI:10.1126/science.270.5236.630
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1126/science.270.5236.630
Verlag, lizenzpflichtig, Volltext: https://www.science.org/doi/10.1126/science.270.5236.630
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Author Notes:Anna Tafuri, Judith Alferink, Peter Möller, Günter J. Hämmerling, Bernd Arnold

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520 |a During pregnancy a semiallogeneic fetus survives despite the presence of maternal T cells specific for paternally inherited histocompatibility antigens. A mouse transgenic for a T cell receptor recognizing the major histocompatibility (MHC) antigen H-2Kb was used to follow the fate of T cells reactive to paternal alloantigens. In contrast to syngeneic and third-party allogeneic pregnancies, mice bearing a Kb-positive conceptus had reduced numbers of Kb-reactive T cells and accepted Kb-positive tumor grafts. T cell phenotype and responsiveness were restored after delivery. Thus, during pregnancy maternal T cells acquire a transient state of tolerance specific for paternal alloantigens. 
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