Elevated soluble ACE2 activity in children and adults after SARS-CoV-2 exposure irrespective of laboratory-confirmed infection: research article
The pivotal role of the cell entry receptor ACE2 for SARS-CoV-2 infection is well-established. When ACE2 is shed from cell surface into plasma as soluble ACE2 (sACE2), it can effectively neutralize SARS-CoV-2. This longitudinal prospective cohort study analyzed sACE2 activity in 1192 participants, a...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
December 2024
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| In: |
Journal of medical virology
Year: 2024, Volume: 96, Issue: 12, Pages: 1-12 |
| ISSN: | 1096-9071 |
| DOI: | 10.1002/jmv.70098 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1002/jmv.70098 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.70098 
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| Author Notes: | Maximilian Stich, Vladimir Gonçalves Magalhães, Friederike Bürger, Sven F. Garbade, Kathrin Jeltsch, Kerstin Mohr, Anneke Haddad, Roland Elling, Peter Lang, Armin Rabsteyn, Eva-Maria Jacobsen, Sebastian F.N. Bode, Barbara Müller, Hans-Georg Kräusslich, Georg Friedrich Hoffmann, Jürgen G. Okun, Ralf Bartenschlager, Marco Binder, Aleš Janda, Hanna Renk, Burkhard Tönshoff |
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| 245 | 1 | 0 | |a Elevated soluble ACE2 activity in children and adults after SARS-CoV-2 exposure irrespective of laboratory-confirmed infection |b research article |c Maximilian Stich, Vladimir Gonçalves Magalhães, Friederike Bürger, Sven F. Garbade, Kathrin Jeltsch, Kerstin Mohr, Anneke Haddad, Roland Elling, Peter Lang, Armin Rabsteyn, Eva-Maria Jacobsen, Sebastian F.N. Bode, Barbara Müller, Hans-Georg Kräusslich, Georg Friedrich Hoffmann, Jürgen G. Okun, Ralf Bartenschlager, Marco Binder, Aleš Janda, Hanna Renk, Burkhard Tönshoff |
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| 520 | |a The pivotal role of the cell entry receptor ACE2 for SARS-CoV-2 infection is well-established. When ACE2 is shed from cell surface into plasma as soluble ACE2 (sACE2), it can effectively neutralize SARS-CoV-2. This longitudinal prospective cohort study analyzed sACE2 activity in 1192 participants, aged 4 months to 81 years, 3 and 12 months after SARS-CoV-2 household exposure. Following SARS-CoV-2 exposure, participants exhibited significantly elevated sACE2 activity, irrespective of confirmed infection, with the highest levels observed in exposed children. Longitudinal analysis revealed a decline in sACE2 levels over time, reaching levels comparable to age- and sex-matched pre-pandemic controls. An increase in sACE2 activity was also confirmed in vitro in Calu-3 (human lung) cells within hours of SARS-CoV-2 exposure, providing a direct link between SARS-CoV-2 exposure and elevated sACE2. This study, therefore, challenges the dichotomy of categorizing SARS-CoV-2 exposed participants as infected or not infected solely on currently established diagnostic assays. It demonstrates lasting host responses independent of B- and T-cell memory and may help to keep SARS-CoV-2 infections in balance and contribute to successful virus clearance in children and adults lacking humoral and cellular immune responses following SARS-CoV-2 exposure. Trial Registration: German Registry for Clinical Studies; Identifier: D 00021521. | ||
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