Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells
Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations is unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45+ imm...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
13 August 2024
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| In: |
Immunity
Year: 2024, Volume: 57, Issue: 8, Pages: 1975-1993.e10 |
| ISSN: | 1097-4180 |
| DOI: | 10.1016/j.immuni.2024.06.015 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.immuni.2024.06.015 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1074761324003212 
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| Author Notes: | Malte Simon, Philipp Stüve, Lisa Schmidleithner, Sebastian Bittner, Niklas Beumer, Nicholas Strieder, Christian Schmidl, Asmita Pant, Claudia Gebhard, Andreas Eigenberger, Michael Rehli, Lukas Prantl, Thomas Hehlgans, Benedikt Brors, Charles D. Imbusch, Michael Delacher, and Markus Feuerer |
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| 245 | 1 | 0 | |a Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells |c Malte Simon, Philipp Stüve, Lisa Schmidleithner, Sebastian Bittner, Niklas Beumer, Nicholas Strieder, Christian Schmidl, Asmita Pant, Claudia Gebhard, Andreas Eigenberger, Michael Rehli, Lukas Prantl, Thomas Hehlgans, Benedikt Brors, Charles D. Imbusch, Michael Delacher, and Markus Feuerer |
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| 520 | |a Tissue adaptation is required for regulatory T (Treg) cell function within organs. Whether this program shares aspects with other tissue-localized immune populations is unclear. Here, we analyzed single-cell chromatin accessibility data, including the transposable element (TE) landscape of CD45+ immune cells from colon, skin, adipose tissue, and spleen. We identified features of organ-specific tissue adaptation across different immune cells. Focusing on tissue Treg cells, we found conservation of the Treg tissue adaptation program in other tissue-localized immune cells, such as amphiregulin-producing T helper (Th)17 cells. Accessible TEs can act as regulatory elements, but their contribution to tissue adaptation is not understood. TE landscape analysis revealed an enrichment of specific transcription factor binding motifs in TE regions within accessible chromatin peaks. TEs, specifically from the LTR family, were located in enhancer regions and associated with tissue adaptation. These findings broaden our understanding of immune tissue residency and provide an important step toward organ-specific immune interventions. | ||
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