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Fusobacterium nucleatum Abundance is Associated with Cachexia in Colorectal Cancer Patients: The ColoCare Study

Background Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established. Methods We evaluated the association...

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Main Authors: Ilozumba, Mmadili (Author) , Lin, Tengda (Author) , Hardikar, Sheetal (Author) , Byrd, Doratha A. (Author) , Round, June L. (Author) , Stephens, W. Zac (Author) , Holowatyj, Andreana N. (Author) , Warby, Christy A. (Author) , Damerell, Victoria (Author) , Li, Christopher I. (Author) , Figueiredo, Jane C. (Author) , Toriola, Adetunji T. (Author) , Shibata, David (Author) , Fillmore, Gary C. (Author) , Pickron, Bartley (Author) , Siegel, Erin M. (Author) , Kahlert, Christoph (Author) , Florou, Vaia (Author) , Gigić, Biljana (Author) , Ose, Jennifer (Author) , Ulrich, Cornelia (Author)
Format: Article (Journal)
Language:English
Published: November 2024
In: Cancer medicine
Year: 2024, Volume: 13, Issue: 22, Pages: 1-8
ISSN:2045-7634
DOI:10.1002/cam4.70431
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1002/cam4.70431
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.70431
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Author Notes:Mmadili N. Ilozumba, Tengda Lin, Sheetal Hardikar, Doratha A. Byrd, June L. Round, W. Zac Stephens, Andreana N. Holowatyj, Christy A. Warby, Victoria Damerell, Christopher I. Li, Jane C. Figueiredo, Adetunji T. Toriola, David Shibata, Gary C. Fillmore, Bartley Pickron, Erin M. Siegel, Christoph Kahlert, Vaia Florou, Biljana Gigic, Jennifer Ose, Cornelia M. Ulrich

MARC

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520 |a Background Cachexia accounts for about 20% of all cancer-related deaths and indicates poor prognosis. The impact of Fusobacterium nucleatum (Fn), a microbial risk factor for colorectal cancer (CRC), on the development of cachexia in CRC has not been established. Methods We evaluated the association between Fn abundance in pre-surgical stool samples and onset of cachexia at 6 months post-surgery in n = 87 patients with stages I-III CRC in the ColoCare Study. Results High fecal Fn abundance compared to negative/low fecal Fn abundance was associated with 4-fold increased risk of cachexia onset at 6 months post-surgery (OR = 4.82, 95% CI = 1.15, 20.10, p = 0.03). Conclusion Our findings suggest that high fecal Fn abundance was associated with an increased risk of cachexia at 6 months post-surgery in CRC patients. This is the first study to link Fn abundance with cachexia in CRC patients, offering novel insights into biological mechanisms and potential management of cancer cachexia. Due to the small sample size, our results should be interpreted with caution. Future studies with larger sample sizes are needed to validate these findings. 
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