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Loss of YTHDC1 m6A reading function promotes invasiveness in urothelial carcinoma of the bladder

Bladder cancer poses significant clinical challenges due to its high metastatic potential and poor prognosis, especially when it progresses to muscle-invasive stages. Here, we show that the m6A reader YTHDC1 is downregulated in muscle-invasive bladder cancer and is negatively correlated with the exp...

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Main Authors: Xu, Jinyun (Author) , Koch, Jonas (Author) , Schmidt, Claudia (Author) , Nientiedt, Malin (Author) , Neuberger, Manuel (Author) , Erben, Philipp (Author) , Michel, Maurice Stephan (Author) , Rodríguez Paredes, Manuel (Author) , Lyko, Frank (Author)
Format: Article (Journal)
Language:English
Published: January 2025
In: Experimental & molecular medicine
Year: 2025, Volume: 57, Issue: 1, Pages: 118-130
ISSN:2092-6413
DOI:10.1038/s12276-024-01377-x
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s12276-024-01377-x
Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s12276-024-01377-x
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Author Notes:Jinyun Xu, Jonas Koch, Claudia Schmidt, Malin Nientiedt, Manuel Neuberger, Philipp Erben, Maurice Stephan Michel, Manuel Rodríguez-Paredes and Frank Lyko
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Summary:Bladder cancer poses significant clinical challenges due to its high metastatic potential and poor prognosis, especially when it progresses to muscle-invasive stages. Here, we show that the m6A reader YTHDC1 is downregulated in muscle-invasive bladder cancer and is negatively correlated with the expression of epithelial‒mesenchymal transition genes. The functional inhibition or depletion of YTHDC1 increased the migration and invasion of urothelial cells. Integrative analysis of multimodal sequencing datasets provided detailed insights into the molecular mechanisms mediating YTHDC1-dependent phenotypes and identified SMAD6 as a key transcript involved in the invasiveness of urothelial carcinoma of the bladder. Notably, SMAD6 mRNA colocalized less with YTHDC1 in tumoral tissues than in paratumoral tissues, indicating disrupted binding during cancer progression. Our findings establish YTHDC1-dependent m6A reading as a critical epitranscriptomic mechanism regulating bladder cancer invasiveness and provide a paradigm for the epitranscriptomic deregulation of cancer-associated networks.
Item Description:Im Titel ist die Zahl 6 hochgestellt
Online veröffentlicht: 1. Januar 2025
Gesehen am 24.07.2025
Physical Description:Online Resource
ISSN:2092-6413
DOI:10.1038/s12276-024-01377-x

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