Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR

In the endoplasmic reticulum, MHC class II αβ dimers associate with the trimeric invariant chain (li), generating a nine-subunit (αβ li)3 complex. In the presence of li, the peptide binding groove is blocked, so that loading with self or antigenic peptides can only occur after proteolytic removal of...

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Bibliographic Details

Main Authors:	Vogt, Anne B. (Author) , Stern, Lawrence J. (Author) , Amshoff, Christine (Author) , Dobberstein, Bernhard (Author) , Hämmerling, Günter J. (Author) , Kropshofer, Harald (Author)
Format:	Article (Journal)
Language:	English
Published:	15 November 1995
In:	The journal of immunology Year: 1995, Volume: 155, Issue: 10, Pages: 4757-4765
ISSN:	1550-6606
DOI:	10.4049/jimmunol.155.10.4757
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.155.10.4757
Author Notes:	A.B. Vogt, L.J. Stern, C. Amshoff, B. Dobberstein, G.J. Hämmerling, H. Kropshofer