Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR
In the endoplasmic reticulum, MHC class II αβ dimers associate with the trimeric invariant chain (li), generating a nine-subunit (αβ li)3 complex. In the presence of li, the peptide binding groove is blocked, so that loading with self or antigenic peptides can only occur after proteolytic removal of...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
15 November 1995
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| In: |
The journal of immunology
Year: 1995, Jahrgang: 155, Heft: 10, Pages: 4757-4765 |
| ISSN: | 1550-6606 |
| DOI: | 10.4049/jimmunol.155.10.4757 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.4049/jimmunol.155.10.4757
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| Verfasserangaben: | A.B. Vogt, L.J. Stern, C. Amshoff, B. Dobberstein, G.J. Hämmerling, H. Kropshofer |
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Interference of distinct invariant chain regions with superantigen contact area and antigenic peptide binding groove of HLA-DR
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