In vivo endocultivation of CAD/CAM hybrid scaffolds in the omentum majus in miniature pigs
Purpose - Correction of bony mandibular defects is a challenge in oral and maxillofacial surgery due to aesthetic and functional requirements. This study investigated the potential of a novel hybrid scaffold for bone regeneration and degradation assessment of the ceramic within the omentum majus ove...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
November 2024
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| In: |
Journal of cranio-maxillofacial surgery
Year: 2024, Volume: 52, Issue: 11, Pages: 1259-1266 |
| ISSN: | 1878-4119 |
| DOI: | 10.1016/j.jcms.2024.04.012 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.jcms.2024.04.012 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1010518224001628 
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| Author Notes: | Juliane Wagner, Lennart Bayer, Klaas Loger, Yahya Acil, Sascha Kurz, Johannes Spille, Matthias Ahlhelm, Lena-Christin Ingwersen, Anika Jonitz-Heincke, Sam Sedaghat, Jörg Wiltfang, Hendrik Naujokat |
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| 245 | 1 | 0 | |a In vivo endocultivation of CAD/CAM hybrid scaffolds in the omentum majus in miniature pigs |c Juliane Wagner, Lennart Bayer, Klaas Loger, Yahya Acil, Sascha Kurz, Johannes Spille, Matthias Ahlhelm, Lena-Christin Ingwersen, Anika Jonitz-Heincke, Sam Sedaghat, Jörg Wiltfang, Hendrik Naujokat |
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| 520 | |a Purpose - Correction of bony mandibular defects is a challenge in oral and maxillofacial surgery due to aesthetic and functional requirements. This study investigated the potential of a novel hybrid scaffold for bone regeneration and degradation assessment of the ceramic within the omentum majus over 6 months and the extent to which rhBMP-2 as a growth factor, alone or combined with a hydrogel, affects regeneration. - Materials and methods - In this animal study, 10 Göttingen minipigs each had one scaffold implanted in the greater omentum. Five animals had scaffolds loaded with a collagen hydrogel and rhBMP-2, and the other five animals (control group) had scaffolds loaded with rhBMP-2 only. Fluorochrome injections and computed tomography (CT) were performed regularly. After 6 months, the animals were euthanized, and samples were collected for microCT and histological evaluations. - Results - Fluorescent and light microscopic and a CT morphological density evaluation showed continuous bone growth until week 16 in both groups. Regarding the ratio of bone attachment to the Zr02 support struts, the rhBMP-2 loaded collagen hydrogel group showed with 63% a significantly higher attachment (p > 0.001) than the rhBMP-2 control group (49%). - Conclusion - In this study, bone growth was induced in all omentum majus specimens until post-operative week 16. Furthermore, hydrogel and rhBMP-2 together resulted in better bone-scaffold integration than rhBMP-2 alone. Further studies should investigate whether implantation of the scaffolds in the jaw after an appropriate period of bone regeneration leads to a stable situation and the desired results. | ||
| 650 | 4 | |a Bone tissue engineering | |
| 650 | 4 | |a Endocultivation | |
| 650 | 4 | |a Facial bone regeneration | |
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| 700 | 1 | |a Loger, Klaas |e VerfasserIn |4 aut | |
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