Matrix protein synthesis by glomerular mesangial cells in culture: Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA
The pathogenesis of glomerular scarring is multifactional; recent evidence suggests that transforming growth factor β (TGFβ), a pleiotropic cicatricial mediator, may promote mesangial sclerosis by enhancing the production of extracellular matrix proteins. We studied the effect of TGFβ1 and TFGβ2 on...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 1995
|
| In: |
Journal of cellular physiology
Year: 1995, Volume: 163, Issue: 3, Pages: 451-457 |
| ISSN: | 1097-4652 |
| DOI: | 10.1002/jcp.1041630304 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/jcp.1041630304 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.1041630304 
|
| Author Notes: | Gertrud Maria Hänsch, Christof Wagner, Antje Bürger, Wenjie Dong, G. Staehler, Michael Stoeck |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1931944717 | ||
| 003 | DE-627 | ||
| 005 | 20250729091255.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250729s1995 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/jcp.1041630304 |2 doi | |
| 035 | |a (DE-627)1931944717 | ||
| 035 | |a (DE-599)KXP1931944717 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Hänsch, Gertrud Maria |e VerfasserIn |0 (DE-588)1032383380 |0 (DE-627)738394076 |0 (DE-576)323810926 |4 aut | |
| 245 | 1 | 0 | |a Matrix protein synthesis by glomerular mesangial cells in culture |b Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA |c Gertrud Maria Hänsch, Christof Wagner, Antje Bürger, Wenjie Dong, G. Staehler, Michael Stoeck |
| 264 | 1 | |c June 1995 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe 4. Februar 2005 | ||
| 500 | |a Gesehen am 29.07.2025 | ||
| 520 | |a The pathogenesis of glomerular scarring is multifactional; recent evidence suggests that transforming growth factor β (TGFβ), a pleiotropic cicatricial mediator, may promote mesangial sclerosis by enhancing the production of extracellular matrix proteins. We studied the effect of TGFβ1 and TFGβ2 on collagen type IV and fibronectin (FN) synthesis in human glomerular mesangial cells in culture (GMC). Two hours after addition of TGFβ, an up to twofold increase in abundance of collagen type IV mRNA was found, which further increased up to fivefold within 24 h. Addition of cycloheximide did not inhibit the TGFβ effect, but caused by itself an up to twofold increase in the abundance of collagen type IV mRNA after 2 h. Together with collagen mRNA, the mRNA for FN and for platelet-derived growth factor (PDGF) was also enhanced. PDGF was found to enhance abundance of the collagen type IV and fibronectin mRNA in GMC. A neutralizing antibody to PDGF or a PDGF-antisense oligonucleotide partly inhibited the TGFβ-induced increase of collagen type IV mRNA, suggesting that TGFβ can affect the collagen type IV synthesis not only directly but also indirectly via the synthesis of PDGF. © 1995 Wiley-Liss, Inc. | ||
| 700 | 1 | |a Wagner, Christof |e VerfasserIn |0 (DE-588)1076408427 |0 (DE-627)835229068 |0 (DE-576)44528482X |4 aut | |
| 700 | 1 | |a Bürger, Antje |d 1969- |e VerfasserIn |0 (DE-588)120984105 |0 (DE-627)705137856 |0 (DE-576)292481373 |4 aut | |
| 700 | 1 | |a Dong, Wenjie |e VerfasserIn |0 (DE-588)1358435200 |0 (DE-627)1918912513 |4 aut | |
| 700 | 1 | |a Staehler, Gerd |d 1939-2014 |e VerfasserIn |0 (DE-588)1076599753 |0 (DE-627)835111067 |0 (DE-576)165122013 |4 aut | |
| 700 | 1 | |a Stöck, Michael |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cellular physiology |d New York, NY [u.a.] : Wiley-Liss, 1932 |g 163(1995), 3, Seite 451-457 |h Online-Ressource |w (DE-627)270929738 |w (DE-600)1478143-8 |w (DE-576)078590175 |x 1097-4652 |7 nnas |a Matrix protein synthesis by glomerular mesangial cells in culture Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA |
| 773 | 1 | 8 | |g volume:163 |g year:1995 |g number:3 |g pages:451-457 |g extent:7 |a Matrix protein synthesis by glomerular mesangial cells in culture Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA |
| 856 | 4 | 0 | |u https://doi.org/10.1002/jcp.1041630304 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/jcp.1041630304 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250729 | ||
| 993 | |a Article | ||
| 994 | |a 1995 | ||
| 998 | |g 1076599753 |a Staehler, Gerd |m 1076599753:Staehler, Gerd |d 910000 |d 910200 |e 910000PS1076599753 |e 910200PS1076599753 |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 1358435200 |a Dong, Wenjie |m 1358435200:Dong, Wenjie |d 50000 |e 50000PD1358435200 |k 0/50000/ |p 4 | ||
| 998 | |g 1076408427 |a Wagner, Christof |m 1076408427:Wagner, Christof |d 50000 |e 50000PW1076408427 |k 0/50000/ |p 2 | ||
| 998 | |g 1032383380 |a Hänsch, Gertrud Maria |m 1032383380:Hänsch, Gertrud Maria |d 910000 |d 911600 |e 910000PH1032383380 |e 911600PH1032383380 |k 0/910000/ |k 1/910000/911600/ |p 1 |x j | ||
| 999 | |a KXP-PPN1931944717 |e 4750393657 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"title":[{"subtitle":"Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNA","title":"Matrix protein synthesis by glomerular mesangial cells in culture","title_sort":"Matrix protein synthesis by glomerular mesangial cells in culture"}],"person":[{"given":"Gertrud Maria","family":"Hänsch","role":"aut","roleDisplay":"VerfasserIn","display":"Hänsch, Gertrud Maria"},{"family":"Wagner","given":"Christof","display":"Wagner, Christof","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Antje","family":"Bürger","role":"aut","display":"Bürger, Antje","roleDisplay":"VerfasserIn"},{"given":"Wenjie","family":"Dong","role":"aut","display":"Dong, Wenjie","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Staehler, Gerd","role":"aut","family":"Staehler","given":"Gerd"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Stöck, Michael","given":"Michael","family":"Stöck"}],"language":["eng"],"recId":"1931944717","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Elektronische Reproduktion der Druck-Ausgabe 4. Februar 2005","Gesehen am 29.07.2025"],"id":{"doi":["10.1002/jcp.1041630304"],"eki":["1931944717"]},"origin":[{"dateIssuedDisp":"June 1995","dateIssuedKey":"1995"}],"name":{"displayForm":["Gertrud Maria Hänsch, Christof Wagner, Antje Bürger, Wenjie Dong, G. Staehler, Michael Stoeck"]},"relHost":[{"origin":[{"publisherPlace":"New York, NY [u.a.]","dateIssuedKey":"1932","publisher":"Wiley-Liss","dateIssuedDisp":"1932-"}],"id":{"zdb":["1478143-8"],"doi":["10.1002/(ISSN)1097-4652"],"eki":["270929738"],"issn":["1097-4652"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"Journal of cellular physiology","title":"Journal of cellular physiology"}],"pubHistory":["1.1932 -"],"part":{"extent":"7","text":"163(1995), 3, Seite 451-457","volume":"163","issue":"3","pages":"451-457","year":"1995"},"titleAlt":[{"title":"Journal of cellular and comparative physiology"}],"note":["Gesehen am 07.10.05"],"disp":"Matrix protein synthesis by glomerular mesangial cells in culture Effects of transforming growth factor β (TGFβ) and platelet-derived growth factor (PDGF) on fibronectin and collagen type IV mRNAJournal of cellular physiology","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"270929738","language":["eng"]}],"physDesc":[{"extent":"7 S."}]} | ||
| SRT | |a HAENSCHGERMATRIXPROT1995 | ||