Repotrectinib in ROS1 Fusion-Positive Non-Small-Cell Lung Cancer
In this phase 1-2 trial, the TK inhibitor repotrectinib led to an objective response in 79% of patients with ROS1 fusion-positive NSCLC and no previous ROS1 TK inhibitor use. Median progression-free survival was nearly 3 years.
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 10, 2024
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| In: |
The New England journal of medicine
Year: 2024, Volume: 390, Issue: 2, Pages: 118-131 |
| ISSN: | 1533-4406 |
| DOI: | 10.1056/NEJMoa2302299 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1056/NEJMoa2302299 Verlag, lizenzpflichtig, Volltext: https://www.nejm.org/doi/full/10.1056/NEJMoa2302299 
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| Author Notes: | Alexander Drilon, D. Ross Camidge, Jessica J. Lin, Sang-We Kim, Benjamin J. Solomon, Rafal Dziadziuszko, Benjamin Besse, Koichi Goto, Adrianus Johannes de Langen, Jürgen Wolf, Ki Hyeong Lee, Sanjay Popat, Christoph Springfeld, Misako Nagasaka, Enriqueta Felip, Nong Yang, Vamsidhar Velcheti, Shun Lu, Steven Kao, Christophe Dooms, Matthew G. Krebs, Wenxiu Yao, Muhammad Shaalan Beg, Xiufeng Hu, Denis Moro-Sibilot, Parneet Cheema, Shanna Stopatschinskaja, Minal Mehta, Denise Trone, Armin Graber, Gregory Sims, Yong Yuan, and Byoung Chul Cho for the TRIDENT-1 investigators |
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