BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia
Established genetic biomarkers in chronic lymphocytic leukemia (CLL) have been useful in predicting response to chemoimmunotherapy but are less predictive of response to targeted therapies. With several such targeted therapies now approved for CLL, identifying novel, non-genetic predictive biomarker...
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| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
03 March 2025
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| In: |
Molecular cancer
Year: 2025, Volume: 24, Pages: 1-19 |
| ISSN: | 1476-4598 |
| DOI: | 10.1186/s12943-025-02260-7 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s12943-025-02260-7
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| Author Notes: | Stephen Jun Fei Chong, Junyan Lu, Rebecca Valentin, Timothy Z. Lehmberg, Jie Qing Eu, Jing Wang, Fen Zhu, Li Ren Kong, Stacey M. Fernandes, Jeremy Zhang, Charles Herbaux, Boon Cher Goh, Jennifer R. Brown, Carsten U. Niemann, Wolfgang Huber, Thorsten Zenz and Matthew S. Davids |
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| 520 | |a Established genetic biomarkers in chronic lymphocytic leukemia (CLL) have been useful in predicting response to chemoimmunotherapy but are less predictive of response to targeted therapies. With several such targeted therapies now approved for CLL, identifying novel, non-genetic predictive biomarkers of response may help to select the optimal therapy for individual patients. | ||
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