The complexity of malignant glioma treatment
Malignant glioma is a highly aggressive, therapeutically non-responsive, and deadly disease with a unique tumor microenvironment (TME). Of the 14 currently recognized and described cancer hallmarks, five are especially implicated in malignant glioma and targetable with repurposed drugs: cancer stem-...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
4 March 2025
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| In: |
Cancers
Year: 2025, Jahrgang: 17, Heft: 5, Pages: 1-35 |
| ISSN: | 2072-6694 |
| DOI: | 10.3390/cancers17050879 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/cancers17050879 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2072-6694/17/5/879 
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| Verfasserangaben: | Linde F. C. Kampers, Dennis S. Metselaar, Maria Vinci, Fabio Scirocchi, Sophie Veldhuijzen van Zanten, Matthias Eyrich, Veronica Biassoni, Esther Hulleman, Michael Karremann, Wilfried Stücker and Stefaan W. Van Gool |
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| 520 | |a Malignant glioma is a highly aggressive, therapeutically non-responsive, and deadly disease with a unique tumor microenvironment (TME). Of the 14 currently recognized and described cancer hallmarks, five are especially implicated in malignant glioma and targetable with repurposed drugs: cancer stem-like cells, in general, and glioma stem-like cells in particular (GSCs), vascularization and hypoxia, metabolic reprogramming, tumor-promoting inflammation and sustained proliferative signaling. Each hallmark drives malignant glioma development, both individually and through interactions with other hallmarks, in which the TME plays a critical role. To combat the aggressive malignant glioma spatio-temporal heterogeneity driven by TME interactions, and to overcome its therapeutic challenges, a combined treatment strategy including anticancer therapies, repurposed drugs and multimodal immunotherapy should be the aim for future treatment approaches. | ||
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