Increased macrophages contribute to thyroid hormone-induced cardiac alterations in mice
Aims The heart is one of the main targets of thyroid hormone. Patients with hyperthyroidism, a disease with high incidence in the population, have increased arrhythmia risk and cardiac hypertrophy, which is an independent predictor of adverse cardiovascular outcomes. Recent research has revealed the...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 2025
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| In: |
Acta physiologica
Year: 2025, Volume: 241, Issue: 3, Pages: 1-16 |
| ISSN: | 1748-1716 |
| DOI: | 10.1111/apha.70011 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/apha.70011 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/apha.70011 
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| Author Notes: | Nathalia Senger, Gislane de Almeida-Santos, Gabriela Cavazza Cerri, Joice Silva Mota, Aline Cristina Parletta, Denival Nascimento Vieira-Junior, Joaquim Teixeira Xavier Junior, Rogério Silva do Nascimento, Danilo Chaves da Silva Ramos de Souza, Maria Claudia Costa Irigoyen, Gabriela Placoná Diniz, José Maria Alvarez Mosig, Tim Christian Kuhn, Florian Leuschner, Maria Regina D'Império Lima, Maria Luiza Morais Barreto-Chaves |
MARC
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| 245 | 1 | 0 | |a Increased macrophages contribute to thyroid hormone-induced cardiac alterations in mice |c Nathalia Senger, Gislane de Almeida-Santos, Gabriela Cavazza Cerri, Joice Silva Mota, Aline Cristina Parletta, Denival Nascimento Vieira-Junior, Joaquim Teixeira Xavier Junior, Rogério Silva do Nascimento, Danilo Chaves da Silva Ramos de Souza, Maria Claudia Costa Irigoyen, Gabriela Placoná Diniz, José Maria Alvarez Mosig, Tim Christian Kuhn, Florian Leuschner, Maria Regina D'Império Lima, Maria Luiza Morais Barreto-Chaves |
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| 520 | |a Aims The heart is one of the main targets of thyroid hormone. Patients with hyperthyroidism, a disease with high incidence in the population, have increased arrhythmia risk and cardiac hypertrophy, which is an independent predictor of adverse cardiovascular outcomes. Recent research has revealed the essential roles of leukocytes in cardiac homeostasis and stress-induced responses. Here, we aimed to evaluate the role of immune cells in cardiac changes induced by elevated triiodothyronine (T3) levels. Methods The hyperthyroid condition in mice was mimicked by daily injections (i.p.) of T3 (14 μg/100 g BW) for 7 or 14 days. Results Increased heart rate and cardiac mass observed after 7 days of T3 treatment was associated with enhanced myocardial population of neutrophils, dendritic cells, and inflammatory phenotypes of monocytes and macrophages, without circulating changes in these cells, as evaluated by flow cytometry. In vitro experiments demonstrated bias toward pro-inflammatory polarization in isolated bone marrow-derived macrophages (BMDM) in response to T3. Interestingly, depletion of macrophages in mice prevented hypertrophic heart growth, tachycardia, and increased gene expression of the pro-inflammatory cytokine interleukin-(IL)-6 caused by hyperthyroid condition. Conclusion Together, these new findings indicate the involvement of macrophages in the cardiac changes promoted by higher T3 levels. Considering that sustained cardiac growth and tachycardia can potentially lead to heart failure, our results suggest that targeting macrophages might be a novel therapeutic approach for attenuating cardiac disorders caused by hyperthyroidism. | ||
| 650 | 4 | |a cardiac hypertrophy | |
| 650 | 4 | |a hyperthyroidism | |
| 650 | 4 | |a immune cells | |
| 650 | 4 | |a inflammation | |
| 650 | 4 | |a macrophages | |
| 650 | 4 | |a T3 | |
| 700 | 1 | |a de Almeida-Santos, Gislane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Cerri, Gabriela Cavazza |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mota, Joice Silva |e VerfasserIn |4 aut | |
| 700 | 1 | |a Parletta, Aline Cristina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vieira-Junior, Denival Nascimento |e VerfasserIn |4 aut | |
| 700 | 1 | |a Junior, Joaquim Teixeira Xavier |e VerfasserIn |4 aut | |
| 700 | 1 | |a do Nascimento, Rogério Silva |e VerfasserIn |4 aut | |
| 700 | 1 | |a da Silva Ramos de Souza, Danilo Chaves |e VerfasserIn |4 aut | |
| 700 | 1 | |a Irigoyen, Maria Claudia Costa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Diniz, Gabriela Placoná |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mosig, José Maria Alvarez |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kuhn, Tim Christian |e VerfasserIn |0 (DE-588)1222754304 |0 (DE-627)1742043992 |4 aut | |
| 700 | 1 | |a Leuschner, Florian |e VerfasserIn |0 (DE-588)1072736144 |0 (DE-627)828165742 |0 (DE-576)189305347 |4 aut | |
| 700 | 1 | |a D'Império Lima, Maria Regina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Barreto-Chaves, Maria Luiza Morais |e VerfasserIn |4 aut | |
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