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A single-nucleus RNA sequencing atlas of the postnatal retina of the shark Scyliorhinus canicula

The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. In recent years, single-cell RNA sequencing studies have uncovered cellular diversity in the retina of a variety of species, providing new insi...

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Hauptverfasser: Vidal-Vázquez, Nicolás (VerfasserIn) , Hernández-Núñez, Ismael (VerfasserIn) , Carballo-Pacoret, Pablo (VerfasserIn) , Salisbury, Sarah (VerfasserIn) , Villamayor, Paula R. (VerfasserIn) , Hervas Sotomayor, Francisca (VerfasserIn) , Yuan, Xuefei (VerfasserIn) , Lamanna, Francesco (VerfasserIn) , Schneider, Céline (VerfasserIn) , Schmidt, Julia (VerfasserIn) , Mazan, Sylvie (VerfasserIn) , Kaessmann, Henrik (VerfasserIn) , Adrio, Fátima (VerfasserIn) , Robledo, Diego (VerfasserIn) , Barreiro-Iglesias, Antón (VerfasserIn) , Candal, Eva (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 07 February 2025
In: Scientific data
Year: 2025, Jahrgang: 12, Pages: 1-11
ISSN:2052-4463
DOI:10.1038/s41597-025-04547-2
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41597-025-04547-2
Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41597-025-04547-2
Volltext
Verfasserangaben:Nicolás Vidal-Vázquez, Ismael Hernández-Núñez, Pablo Carballo-Pacoret, Sarah Salisbury, Paula R. Villamayor, Francisca Hervas-Sotomayor, Xuefei Yuan, Francesco Lamanna, Céline Schneider, Julia Schmidt, Sylvie Mazan, Henrik Kaessmann, Fátima Adrio, Diego Robledo, Antón Barreiro-Iglesias & Eva Candal
Beschreibung
Zusammenfassung:The retina, whose basic cellular structure is highly conserved across vertebrates, constitutes an accessible system for studying the central nervous system. In recent years, single-cell RNA sequencing studies have uncovered cellular diversity in the retina of a variety of species, providing new insights on retinal evolution and development. However, similar data in cartilaginous fishes, the sister group to all other extant jawed vertebrates, are still lacking. Here, we present a single-nucleus RNA sequencing atlas of the postnatal retina of the catshark Scyliorhinus canicula, consisting of the expression profiles for 17,438 individual cells from three female, juvenile catshark specimens. Unsupervised clustering revealed 22 distinct cell types comprising all major retinal cell classes, as well as retinal progenitor cells (whose presence reflects the persistence of proliferative activity in postnatal stages in sharks) and oligodendrocytes. Thus, our dataset serves as a foundation for further studies on the development and function of the catshark retina. Moreover, integration of our atlas with data from other species will allow for a better understanding of vertebrate retinal evolution.
Beschreibung:Gesehen am 01.08.2025
Beschreibung:Online Resource
ISSN:2052-4463
DOI:10.1038/s41597-025-04547-2

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