CAR-NK cell therapy combined with checkpoint inhibition induces an NKT cell response in glioblastoma

Glioblastoma is the most aggressive primary brain tumor with limited efficacy of established therapies, and a pronounced immunosuppressive tumor microenvironment. Targeting HER2 with local immunotherapy allows for high tumor specificity in the brain with physiologically very low expression. Monother...

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Bibliographic Details

Main Authors:	Strassheimer, F. (Author) , Elleringmann, P. (Author) , Ludmirski, G. (Author) , Roller, B. (Author) , Macas, J. (Author) , Alekseeva, T. (Author) , Cakmak, P. (Author) , Aliraj, B. (Author) , Krenzlin, H. (Author) , Demes, M. C. (Author) , Mildenberger, Iris (Author) , Tonn, T. (Author) , Weber, K. J. (Author) , Reiss, Y. (Author) , Plate, K. H. (Author) , Weigert, A. (Author) , Wels, W. S. (Author) , Steinbach, J. P. (Author) , Burger, M. C. (Author)
Format:	Article (Journal)
Language:	English
Published:	18 May 2025
In:	British journal of cancer Year: 2025, Volume: 132, Issue: 9, Pages: 849-860
ISSN:	1532-1827
DOI:	10.1038/s41416-025-02977-8
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41416-025-02977-8 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41416-025-02977-8
Author Notes:	F. Strassheimer, P. Elleringmann, G. Ludmirski, B. Roller, J. Macas, T. Alekseeva, P. Cakmak, B. Aliraj, H. Krenzlin, M. C. Demes, I. C. Mildenberger, T. Tonn, K. J. Weber, Y. Reiss, K. H. Plate, A. Weigert, W. S. Wels, J. P. Steinbach and M. C. Burger