Low tumor interleukin-1β expression predicts a limited effect of adjuvant platinum-based chemotherapy for patients with completely resected lung adenocarcinoma: an identification and validation study
Adjuvant platinum-based chemotherapy for completely resected non-small cell lung cancer is associated with modest improvement in survival; nevertheless, no validated biomarker exists for predicting the benefit or harm of adjuvant platinum-based chemotherapy. We simultaneously measured 27 cytokines i...
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| Hauptverfasser: | , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
24 Oct 2024
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| In: |
Pulmonology
Year: 2025, Jahrgang: 31, Heft: 1, Pages: 1-11 |
| ISSN: | 2531-0437 |
| DOI: | 10.1016/j.pulmoe.2024.03.003 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.pulmoe.2024.03.003 Verlag, kostenfrei, Volltext: https://www.tandfonline.com/doi/full/10.1016/j.pulmoe.2024.03.003 
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| Verfasserangaben: | S. Safi, J. Krzykalla, H. Hoffmann, A. Benner, H. Bischoff, M. Eichhorn, M. Kriegsmann, I. Poschke, F. Stögbauer, L. Umansky, C. Mogler, W. Weichert, H. Winter, P. Beckhove & T. Muley |
MARC
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| 245 | 1 | 0 | |a Low tumor interleukin-1β expression predicts a limited effect of adjuvant platinum-based chemotherapy for patients with completely resected lung adenocarcinoma |b an identification and validation study |c S. Safi, J. Krzykalla, H. Hoffmann, A. Benner, H. Bischoff, M. Eichhorn, M. Kriegsmann, I. Poschke, F. Stögbauer, L. Umansky, C. Mogler, W. Weichert, H. Winter, P. Beckhove & T. Muley |
| 246 | 3 | 3 | |a Low tumor interleukin-1beta expression predicts a limited effect of adjuvant platinum-based chemotherapy for patients with completely resected lung adenocarcinoma |
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| 520 | |a Adjuvant platinum-based chemotherapy for completely resected non-small cell lung cancer is associated with modest improvement in survival; nevertheless, no validated biomarker exists for predicting the benefit or harm of adjuvant platinum-based chemotherapy. We simultaneously measured 27 cytokines in operative tumor specimens from a discovery cohort (n = 97) by multiplex immunoassay; half of the patients received adjuvant platinum-based chemotherapy, and the other half were observed. We tested possible prognostic and predictive factors in multivariate Cox models for overall survival (OS) and relapse-free survival (RFS), and a tree-based method was applied to detect predictive factors with respect to RFS. The results were validated in an independent validation cohort (n = 93). Fifty-two of 97 (54 %) patients in the discovery cohort and 50 of 93 (54 %) in the validation cohort received adjuvant chemotherapy; forty-four (85 %) patients in the discovery cohort and 37 (74 %) in the validation cohort received four cycles as planned. In patients with low IL-1β-expressing tumors, RFS and OS were worse after adjuvant chemotherapy than after observation. The limited effect of adjuvant chemotherapy for patients with low IL-1β-expressing tumors was confirmed in the validation cohort. Additionally, RFS and OS were prolonged by adjuvant chemotherapy only in patients with high IL-1β-expressing tumors in the validation cohort. This study identified and validated low tumor IL-1β expression as a potential biomarker of a limited response to adjuvant platinum-based chemotherapy after complete resection of pulmonary adenocarcinoma. This finding has the potential to inform adjuvant treatment decisions. | ||
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