Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced-phase shifts of the mammalian circadian clock
Light-induced phase shifts of circadian rhythmic locomotor activity are associated with the expression of c-Jun, JunB, c-Fos and FosB transcription factors in the rat suprachiasmatic nucleus, as shown in the present study. In order to explore the importance of c-Fos and JunB, the predominantly expre...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
March 1995
|
| In: |
European journal of neuroscience
Year: 1995, Jahrgang: 7, Heft: 3, Pages: 388-393 |
| ISSN: | 1460-9568 |
| DOI: | 10.1111/j.1460-9568.1995.tb00334.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1460-9568.1995.tb00334.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1460-9568.1995.tb00334.x 
|
| Verfasserangaben: | F. Wollnik, W. Brysch, E. Uhlmann, F. Gillardon, R. Bravo, M. Zimmermann, K.H. Schlingensiepen, T. Herdegen |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1933263792 | ||
| 003 | DE-627 | ||
| 005 | 20250814142218.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250814s1995 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/j.1460-9568.1995.tb00334.x |2 doi | |
| 035 | |a (DE-627)1933263792 | ||
| 035 | |a (DE-599)KXP1933263792 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Wollnik, Franziska |d 1957-2013 |e VerfasserIn |0 (DE-588)1052825435 |0 (DE-627)789088266 |0 (DE-576)408559357 |4 aut | |
| 245 | 1 | 0 | |a Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced-phase shifts of the mammalian circadian clock |c F. Wollnik, W. Brysch, E. Uhlmann, F. Gillardon, R. Bravo, M. Zimmermann, K.H. Schlingensiepen, T. Herdegen |
| 264 | 1 | |c March 1995 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 14.08.2025 | ||
| 520 | |a Light-induced phase shifts of circadian rhythmic locomotor activity are associated with the expression of c-Jun, JunB, c-Fos and FosB transcription factors in the rat suprachiasmatic nucleus, as shown in the present study. In order to explore the importance of c-Fos and JunB, the predominantly expressed AP-1 proteins for the phase-shifting effects of light, we blocked the expression of c-Fos and JunB in the suprachiasmatic nucleus of male rats, housed under constant darkness, by intracerebroventricular application of 2 μ1 of 1 mM antisense phosphorothioate oligodeoxynucleotides (ASO) specifically directed against c-fos and JunB mRNA. A light pulse (300 lux for 1 h) at circadian time 15 induced a significant phase shift (by 125 ± 15 min) of the circadian locomotor activity rhythm, whereas application of AS0 6 h before the light pulse completely prevented this phase shift. Application of control nonsense oligodeoxynucleotides had no effect. ASO strongly reduced the light-induced expression of c-Fos and JunB proteins. In contrast, light pulses with or without the control nonsense oligodeoxynucleotides evoked strong nuclear c-Fos and JunB immunoreactivity in the rat suprachiasmatic nucleus. These results demonstrate for the first time that inducible transcription factors such as c-Fos and JunB are an essential part of fundamental biological processes in the adult mammalian nervous system, e.g. of light-induced phase shifts of the circadian pacemaker. | ||
| 650 | 4 | |a c-Jun | |
| 650 | 4 | |a FosB | |
| 650 | 4 | |a immediate-early gene | |
| 650 | 4 | |a inducible transcription factor | |
| 650 | 4 | |a rat | |
| 650 | 4 | |a suprachiasmatic nucleus | |
| 700 | 1 | |a Brysch, W. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Uhlmann, E. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gillardon, Frank |e VerfasserIn |0 (DE-588)1094921580 |0 (DE-627)855380632 |0 (DE-576)169720764 |4 aut | |
| 700 | 1 | |a Bravo, R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zimmermann, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlingensiepen, K. H. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Herdegen, Thomas |d 1959- |e VerfasserIn |0 (DE-588)140946179 |0 (DE-627)622965611 |0 (DE-576)321478401 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of neuroscience |d Oxford [u.a.] : Wiley, 1989 |g 7(1995), 3, Seite 388-393 |h Online-Ressource |w (DE-627)320443299 |w (DE-600)2005178-5 |w (DE-576)090954696 |x 1460-9568 |7 nnas |a Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced-phase shifts of the mammalian circadian clock |
| 773 | 1 | 8 | |g volume:7 |g year:1995 |g number:3 |g pages:388-393 |g extent:6 |a Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced-phase shifts of the mammalian circadian clock |
| 856 | 4 | 0 | |u https://doi.org/10.1111/j.1460-9568.1995.tb00334.x |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1460-9568.1995.tb00334.x |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250814 | ||
| 993 | |a Article | ||
| 994 | |a 1995 | ||
| 998 | |g 140946179 |a Herdegen, Thomas |m 140946179:Herdegen, Thomas |d 50000 |d 53200 |e 50000PH140946179 |e 53200PH140946179 |k 0/50000/ |k 1/50000/53200/ |p 8 |y j | ||
| 998 | |g 1094921580 |a Gillardon, Frank |m 1094921580:Gillardon, Frank |d 50000 |e 50000PG1094921580 |k 0/50000/ |p 4 | ||
| 999 | |a KXP-PPN1933263792 |e 4757360185 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced-phase shifts of the mammalian circadian clockEuropean journal of neuroscience","note":["Gesehen am 03.05.06"],"language":["eng"],"recId":"320443299","pubHistory":["1.1989 -"],"part":{"volume":"7","text":"7(1995), 3, Seite 388-393","extent":"6","year":"1995","issue":"3","pages":"388-393"},"titleAlt":[{"title":"EJN"}],"title":[{"title_sort":"European journal of neuroscience","subtitle":"EJN","title":"European journal of neuroscience"}],"physDesc":[{"extent":"Online-Ressource"}],"name":{"displayForm":["European Neuroscience Association"]},"origin":[{"publisherPlace":"Oxford [u.a.] ; Oxford ; Oxford [u.a.]","dateIssuedDisp":"1989-","publisher":"Wiley ; Blackwell Science ; Blackwell","dateIssuedKey":"1989"}],"id":{"zdb":["2005178-5"],"doi":["10.1111/(ISSN)1460-9568"],"eki":["320443299"],"issn":["1460-9568"]}}],"physDesc":[{"extent":"6 S."}],"id":{"doi":["10.1111/j.1460-9568.1995.tb00334.x"],"eki":["1933263792"]},"origin":[{"dateIssuedKey":"1995","dateIssuedDisp":"March 1995"}],"name":{"displayForm":["F. Wollnik, W. Brysch, E. Uhlmann, F. Gillardon, R. Bravo, M. Zimmermann, K.H. Schlingensiepen, T. Herdegen"]},"language":["eng"],"recId":"1933263792","type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 14.08.2025"],"title":[{"title":"Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced-phase shifts of the mammalian circadian clock","title_sort":"Block of c-Fos and JunB expression by antisense oligonucleotides inhibits light-induced-phase shifts of the mammalian circadian clock"}],"person":[{"given":"Franziska","family":"Wollnik","role":"aut","display":"Wollnik, Franziska","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Brysch, W.","role":"aut","family":"Brysch","given":"W."},{"roleDisplay":"VerfasserIn","display":"Uhlmann, E.","role":"aut","family":"Uhlmann","given":"E."},{"given":"Frank","family":"Gillardon","role":"aut","display":"Gillardon, Frank","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Bravo, R.","given":"R.","family":"Bravo"},{"display":"Zimmermann, M.","roleDisplay":"VerfasserIn","role":"aut","family":"Zimmermann","given":"M."},{"roleDisplay":"VerfasserIn","display":"Schlingensiepen, K. H.","role":"aut","family":"Schlingensiepen","given":"K. H."},{"display":"Herdegen, Thomas","roleDisplay":"VerfasserIn","role":"aut","family":"Herdegen","given":"Thomas"}]} | ||
| SRT | |a WOLLNIKFRABLOCKOFCFO1995 | ||