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Making sense of scattering: seeing microstructure through shear waves

The physics of shear waves traveling through matter carries fundamental insights into its structure, for instance, quantifying stiffness for disease characterization. However, the origin of shear wave attenuation in tissue is currently not properly understood. Attenuation is caused by two phenomena:...

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Main Authors: Annio, Giacomo (Author) , Holm, Sverre (Author) , Mangin, Gabrielle (Author) , Penney, Jake (Author) , Bacquët, Raphael (Author) , Mustapha, Rami (Author) , Darwish, Omar (Author) , Wittgenstein, Anna Sophie (Author) , Schregel, Katharina (Author) , Vilgrain, Valérie (Author) , Paradis, Valérie (Author) , Sølna, Knut (Author) , Nordsletten, David Alexander (Author) , Sinkus, Ralph (Author)
Format: Article (Journal)
Language:English
Published: Aug 2024
In: Science advances
Year: 2024, Volume: 10, Issue: 31, Pages: 1-11
ISSN:2375-2548
DOI:10.1126/sciadv.adp3363
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1126/sciadv.adp3363
Verlag, kostenfrei, Volltext: https://www.science.org/doi/10.1126/sciadv.adp3363
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Author Notes:Giacomo Annio, Sverre Holm, Gabrielle Mangin, Jake Penney, Raphael Bacquët, Rami Mustapha, Omar Darwish, Anna Sophie Wittgenstein, Katharina Schregel, Valérie Vilgrain, Valérie Paradis, Knut Sølna, David Alexander Nordsletten, Ralph Sinkus

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520 |a The physics of shear waves traveling through matter carries fundamental insights into its structure, for instance, quantifying stiffness for disease characterization. However, the origin of shear wave attenuation in tissue is currently not properly understood. Attenuation is caused by two phenomena: absorption due to energy dissipation and scattering on structures such as vessels fundamentally tied to the material’s microstructure. Here, we present a scattering theory in conjunction with magnetic resonance imaging, which enables the unraveling of a material’s innate constitutive and scattering characteristics. By overcoming a three-order-of-magnitude scale difference between wavelength and average intervessel distance, we provide noninvasively a macroscopic measure of vascular architecture. The validity of the theory is demonstrated through simulations, phantoms, in vivo mice, and human experiments and compared against histology as gold standard. Our approach expands the field of imaging by using the dispersion properties of shear waves as macroscopic observable proxies for deciphering the underlying ultrastructures. 
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