Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism
Acrolein (ACR) is an endogenous reactive unsaturated aldehyde that can be detoxified by the aldo-keto reductase (AKR) enzyme system. While it has been shown that accumulation of ACR is associated with several health problems, including inflammation, oxidative stress, and cardiovascular disease the s...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2025
|
| In: |
Redox Biology
Year: 2025, Volume: 83, Pages: 1-15 |
| ISSN: | 2213-2317 |
| DOI: | 10.1016/j.redox.2025.103639 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.redox.2025.103639 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2213231725001521 
|
| Author Notes: | Xin Zhang, Johannes Gschwind, Vanessa Erben, Katrin Bennewitz, Xiaogang Li, Carsten Sticht, Gernot Poschet, Ingrid Hausser, Thomas Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1933371404 | ||
| 003 | DE-627 | ||
| 005 | 20250818105043.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250818s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.redox.2025.103639 |2 doi | |
| 035 | |a (DE-627)1933371404 | ||
| 035 | |a (DE-599)KXP1933371404 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Zhang, Xin |d 1991- |e VerfasserIn |0 (DE-588)1354498445 |0 (DE-627)191561712X |4 aut | |
| 245 | 1 | 0 | |a Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism |c Xin Zhang, Johannes Gschwind, Vanessa Erben, Katrin Bennewitz, Xiaogang Li, Carsten Sticht, Gernot Poschet, Ingrid Hausser, Thomas Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll |
| 264 | 1 | |c June 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 15 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 17. April 2025, Artikelversion: 20. April 2025 | ||
| 500 | |a Gesehen am 18.08.2025 | ||
| 520 | |a Acrolein (ACR) is an endogenous reactive unsaturated aldehyde that can be detoxified by the aldo-keto reductase (AKR) enzyme system. While it has been shown that accumulation of ACR is associated with several health problems, including inflammation, oxidative stress, and cardiovascular disease the study aimed to analyze whether an endogenous accumulation of ACR is causal for vascular dysfunction in an akr7a3 mutant zebrafish model. Enlargement of the hyaloid and retinal vasculature, as well as alterations in the larval pronephros and thickening of the glomerular basement membrane in the adult kidney were found upon ACR accumulation. Transcriptomic and metabolomic analyses, followed by functional validation, revealed that the up-regulation of genes controlling the arachidonic acid metabolism and activation of the leukotriene pathway are responsible for the observed microvascular changes. In conclusion, the data have identified an intrinsic function of ACR in akr7a3 mutants that activates the arachidonic acid metabolism and subsequently disrupts vascular integrity by promoting an inflammatory response. Thus, ACR is causal in the development of vascular disease. | ||
| 650 | 4 | |a Acrolein | |
| 650 | 4 | |a Aldo-keto reductase | |
| 650 | 4 | |a Arachidonic acid metabolism | |
| 650 | 4 | |a Kidney alteration | |
| 650 | 4 | |a Ocular vascular diseases | |
| 650 | 4 | |a Zebrafish | |
| 700 | 1 | |a Gschwind, Johannes |e VerfasserIn |4 aut | |
| 700 | 1 | |a Erben, Vanessa |d 1992- |e VerfasserIn |0 (DE-588)1155543386 |0 (DE-627)1017810176 |0 (DE-576)399162941 |4 aut | |
| 700 | 1 | |a Bennewitz, Katrin |d 1981- |e VerfasserIn |0 (DE-588)1154553140 |0 (DE-627)1015942172 |0 (DE-576)501101209 |4 aut | |
| 700 | 1 | |a Li, Xiaogang |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sticht, Carsten |d 1972- |e VerfasserIn |0 (DE-588)1020115718 |0 (DE-627)691110077 |0 (DE-576)250042177 |4 aut | |
| 700 | 1 | |a Poschet, Gernot |e VerfasserIn |0 (DE-588)1030300712 |0 (DE-627)735006652 |0 (DE-576)378100572 |4 aut | |
| 700 | 1 | |a Haußer-Siller, Ingrid |d 1957- |e VerfasserIn |0 (DE-588)1058096710 |0 (DE-627)796384703 |0 (DE-576)163782377 |4 aut | |
| 700 | 1 | |a Fleming, Thomas |d 1982- |e VerfasserIn |0 (DE-588)1034445294 |0 (DE-627)745607365 |0 (DE-576)382066804 |4 aut | |
| 700 | 1 | |a Szendrödi, Julia |e VerfasserIn |0 (DE-588)1226436463 |0 (DE-627)1747448249 |4 aut | |
| 700 | 1 | |a Nawroth, Peter Paul |d 1954- |e VerfasserIn |0 (DE-588)1020504897 |0 (DE-627)69123941X |0 (DE-576)360517692 |4 aut | |
| 700 | 1 | |a Kroll, Jens |d 1969- |e VerfasserIn |0 (DE-588)1032295619 |0 (DE-627)738209503 |0 (DE-576)379947544 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Redox Biology |d Amsterdam [u.a.] : Elsevier, 2013 |g 83(2025), Artikel-ID 103639, Seite 1-15 |h Online-Ressource |w (DE-627)735687307 |w (DE-600)2701011-9 |w (DE-576)378492055 |x 2213-2317 |7 nnas |a Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism |
| 773 | 1 | 8 | |g volume:83 |g year:2025 |g elocationid:103639 |g pages:1-15 |g extent:15 |a Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.redox.2025.103639 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S2213231725001521 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250818 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1032295619 |a Kroll, Jens |m 1032295619:Kroll, Jens |d 60000 |d 65000 |d 60000 |e 60000PK1032295619 |e 65000PK1032295619 |e 60000PK1032295619 |k 0/60000/ |k 1/60000/65000/ |k 0/60000/ |p 12 |y j | ||
| 998 | |g 1020504897 |a Nawroth, Peter Paul |m 1020504897:Nawroth, Peter Paul |d 50000 |e 50000PN1020504897 |k 0/50000/ |p 11 | ||
| 998 | |g 1226436463 |a Szendrödi, Julia |m 1226436463:Szendrödi, Julia |d 910000 |d 910100 |e 910000PS1226436463 |e 910100PS1226436463 |k 0/910000/ |k 1/910000/910100/ |p 10 | ||
| 998 | |g 1034445294 |a Fleming, Thomas |m 1034445294:Fleming, Thomas |d 910000 |d 910100 |e 910000PF1034445294 |e 910100PF1034445294 |k 0/910000/ |k 1/910000/910100/ |p 9 | ||
| 998 | |g 1058096710 |a Haußer-Siller, Ingrid |m 1058096710:Haußer-Siller, Ingrid |d 910000 |d 912000 |e 910000PH1058096710 |e 912000PH1058096710 |k 0/910000/ |k 1/910000/912000/ |p 8 | ||
| 998 | |g 1030300712 |a Poschet, Gernot |m 1030300712:Poschet, Gernot |d 700000 |d 721000 |e 700000PP1030300712 |e 721000PP1030300712 |k 0/700000/ |k 1/700000/721000/ |p 7 | ||
| 998 | |g 1020115718 |a Sticht, Carsten |m 1020115718:Sticht, Carsten |d 60000 |d 60200 |d 60210 |e 60000PS1020115718 |e 60200PS1020115718 |e 60210PS1020115718 |k 0/60000/ |k 1/60000/60200/ |k 2/60000/60200/60210/ |p 6 | ||
| 998 | |g 1154553140 |a Bennewitz, Katrin |m 1154553140:Bennewitz, Katrin |d 60000 |d 65000 |e 60000PB1154553140 |e 65000PB1154553140 |k 0/60000/ |k 1/60000/65000/ |p 4 | ||
| 998 | |g 1155543386 |a Erben, Vanessa |m 1155543386:Erben, Vanessa |d 60000 |e 60000PE1155543386 |k 0/60000/ |p 3 | ||
| 998 | |g 1354498445 |a Zhang, Xin |m 1354498445:Zhang, Xin |d 60000 |e 60000PZ1354498445 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1933371404 |e 4758600392 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"title_sort":"Redox Biology","subtitle":"an official journal of the Society for Free Radical Biology and Medicine, an official journal of the Society for Free Radical Research-Europe, an affiliate journal of the International Society for Free Radical Research (SFRRI)","title":"Redox Biology"}],"note":["Gesehen am 13.08.20"],"id":{"issn":["2213-2317"],"eki":["735687307"],"zdb":["2701011-9"]},"origin":[{"dateIssuedDisp":"2013-","dateIssuedKey":"2013","publisherPlace":"Amsterdam [u.a.]","publisher":"Elsevier"}],"pubHistory":["1.2013 -"],"part":{"volume":"83","pages":"1-15","text":"83(2025), Artikel-ID 103639, Seite 1-15","extent":"15","year":"2025"},"disp":"Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolismRedox Biology","recId":"735687307","type":{"media":"Online-Ressource","bibl":"periodical"}}],"person":[{"given":"Xin","role":"aut","display":"Zhang, Xin","family":"Zhang"},{"role":"aut","display":"Gschwind, Johannes","family":"Gschwind","given":"Johannes"},{"role":"aut","family":"Erben","display":"Erben, Vanessa","given":"Vanessa"},{"display":"Bennewitz, Katrin","family":"Bennewitz","role":"aut","given":"Katrin"},{"given":"Xiaogang","family":"Li","display":"Li, Xiaogang","role":"aut"},{"role":"aut","family":"Sticht","display":"Sticht, Carsten","given":"Carsten"},{"given":"Gernot","role":"aut","family":"Poschet","display":"Poschet, Gernot"},{"family":"Haußer-Siller","display":"Haußer-Siller, Ingrid","role":"aut","given":"Ingrid"},{"role":"aut","display":"Fleming, Thomas","family":"Fleming","given":"Thomas"},{"display":"Szendrödi, Julia","family":"Szendrödi","role":"aut","given":"Julia"},{"role":"aut","display":"Nawroth, Peter Paul","family":"Nawroth","given":"Peter Paul"},{"role":"aut","display":"Kroll, Jens","family":"Kroll","given":"Jens"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"June 2025"}],"id":{"doi":["10.1016/j.redox.2025.103639"],"eki":["1933371404"]},"recId":"1933371404","note":["Online veröffentlicht: 17. April 2025, Artikelversion: 20. April 2025","Gesehen am 18.08.2025"],"name":{"displayForm":["Xin Zhang, Johannes Gschwind, Vanessa Erben, Katrin Bennewitz, Xiaogang Li, Carsten Sticht, Gernot Poschet, Ingrid Hausser, Thomas Fleming, Julia Szendroedi, Peter Paul Nawroth, Jens Kroll"]},"language":["eng"],"title":[{"title":"Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism","title_sort":"Endogenous acrolein accumulation in akr7a3 mutants causes microvascular dysfunction due to increased arachidonic acid metabolism"}],"physDesc":[{"extent":"15 S.","noteIll":"Illustrationen"}]} | ||
| SRT | |a ZHANGXINGSENDOGENOUS2025 | ||