Post-treatment monitoring of surgically treated oropharyngeal squamous cell carcinoma patients using human papillomavirus cell-free DNA
Introduction - The incidence rate of human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Despite good prognosis, recurrence can decrease health-related quality of life and increase mortality, so post-treatment monitoring is important for patient outcomes. O...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 2025
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| In: |
Oral oncology
Year: 2025, Jahrgang: 163, Pages: 1-7 |
| ISSN: | 1879-0593 |
| DOI: | 10.1016/j.oraloncology.2025.107225 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.oraloncology.2025.107225 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S1368837525000545 
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| Verfasserangaben: | Fabian Rosing, Michaela Plath, Tanja Proctor, Daniela Höfler, Yvonne Alt, Carlota Lucena-Porcel, Tim Waterboer, Jochen Hess, Karim Plath, Lea Schroeder |
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| 245 | 1 | 0 | |a Post-treatment monitoring of surgically treated oropharyngeal squamous cell carcinoma patients using human papillomavirus cell-free DNA |c Fabian Rosing, Michaela Plath, Tanja Proctor, Daniela Höfler, Yvonne Alt, Carlota Lucena-Porcel, Tim Waterboer, Jochen Hess, Karim Plath, Lea Schroeder |
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| 520 | |a Introduction - The incidence rate of human papillomavirus (HPV)-driven oropharyngeal squamous cell carcinoma (OPSCC) is increasing. Despite good prognosis, recurrence can decrease health-related quality of life and increase mortality, so post-treatment monitoring is important for patient outcomes. One potential biomarker for post-treatment monitoring is HPV cell-free DNA (cfDNA) from blood plasma. - Methods - Plasma samples at start of treatment and during follow-up from 27 OPSCC patients were analyzed for cfDNA of six high-risk HPV types using a multiplex digital PCR assay. Presence of HPV cfDNA was compared to HPV tumor status determined by p16INK4a immunohistochemistry, HPV DNA, HPV RNA and HPV16 E6 serology. - Results - At start of treatment, sensitivity of HPV cfDNA detection in HPV-driven OPSCC cases was 89 % (17/19), while specificity was 100 % among 39 plasma samples from 8 HPV-negative OPSCC cases. A median of 4 follow-up plasma samples per patient over a mean time of 11 months were available. Positive and negative predictive values during follow-up were assessed on a per-test-basis. HPV cfDNA testing after completion of therapy had a positive predictive value of 100 % for HPV-OPSCC recurrence within one year, and a negative predictive value of 98 %. In cases of recurrent HPV-driven OPSCC, HPV cfDNA was detectable between 3 and 6.8 months before detection of recurrence by routine follow-up examination methods. - Conclusion - Post-treatment monitoring for early detection of recurrence could be aided by testing for HPV cfDNA in HPV-driven OPSCC patients. | ||
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