Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer
Rectal carcinomas of previously untreated patients were analyzed for oxygen status using a computerized polarographic needle electrode histograph. Microvessel density and expression of c-jun, vascular endothelial growth factor (VEGF) and several resistance-related proteins (glutathione S-transferase...
Gespeichert in:
| Hauptverfasser: | , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 July 1996
|
| In: |
International journal of cancer
Year: 1996, Jahrgang: 67, Heft: 1, Pages: 20-23 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291097-0215%2819960703%2967%3A1%3C20%3A%3AAID-IJC5%3E3.0.CO%3B2-1 
|
| Verfasserangaben: | Jürgen Mattern, Friedrich Kallinowski, Christian Herfarth, Manfred Volm |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1933593881 | ||
| 003 | DE-627 | ||
| 005 | 20250820092618.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250820s1996 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1 |2 doi | |
| 035 | |a (DE-627)1933593881 | ||
| 035 | |a (DE-599)KXP1933593881 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Mattern, Jürgen |d 1940- |e VerfasserIn |0 (DE-588)1027036945 |0 (DE-627)728152525 |0 (DE-576)372422284 |4 aut | |
| 245 | 1 | 0 | |a Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer |c Jürgen Mattern, Friedrich Kallinowski, Christian Herfarth, Manfred Volm |
| 264 | 1 | |c 3 July 1996 | |
| 300 | |a 4 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe 6. Dezember 1998 | ||
| 500 | |a Gesehen am 20.08.2025 | ||
| 520 | |a Rectal carcinomas of previously untreated patients were analyzed for oxygen status using a computerized polarographic needle electrode histograph. Microvessel density and expression of c-jun, vascular endothelial growth factor (VEGF) and several resistance-related proteins (glutathione S-transferase-π, GST; thymidylate synthase, TS; metallothioneine, MT) were determined using immunohistochemistry. To examine whether a relationship exists between intratumoral vessel density and tumor oxygenation, microvessel counts were determined in a 400× field using factor-VIII-related antigen and were correlated with the corresponding pO2 values. Linear regression analysis revealed a significant relationship between vessel density and oxygenation status of the tumors. Expression of c-jun, VEGF and resistance-related proteins was correlated with microvessel counts and pO2 values. Significantly lower vessel counts were found in GST- and MT-positive tumors and in tumors with overexpression of c-jun and VEGF than in negative tumors. In addition, significantly lower pO2 values were found in c-jun- and VEGF-positive tumors as well as a tendency for pO2 values to be lower in tumors where MT, GST and TS were expressed. These data show that expression of c-jun, VEGF, and resistance-related proteins is linked with poor vascularization and low oxygenation status in rectal cancer. © 1996 Wiley-Liss, Inc. | ||
| 700 | 1 | |a Kallinowski, Friedrich |d 1959- |e VerfasserIn |0 (DE-588)1043912606 |0 (DE-627)77104254X |0 (DE-576)396018661 |4 aut | |
| 700 | 1 | |a Herfarth, Christian |d 1933-2014 |e VerfasserIn |0 (DE-588)120706385 |0 (DE-627)080841562 |0 (DE-576)213333414 |4 aut | |
| 700 | 1 | |a Volm, Manfred |e VerfasserIn |0 (DE-588)1068082259 |0 (DE-627)819632171 |0 (DE-576)427285666 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t International journal of cancer |d Bognor Regis : Wiley-Liss, 1966 |g 67(1996), 1, Seite 20-23 |h Online-Ressource |w (DE-627)269532781 |w (DE-600)1474822-8 |w (DE-576)079876129 |x 1097-0215 |7 nnas |a Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer |
| 773 | 1 | 8 | |g volume:67 |g year:1996 |g number:1 |g pages:20-23 |g extent:4 |a Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer |
| 856 | 4 | 0 | |u https://doi.org/10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291097-0215%2819960703%2967%3A1%3C20%3A%3AAID-IJC5%3E3.0.CO%3B2-1 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250820 | ||
| 994 | |a 1996 | ||
| 998 | |g 1068082259 |a Volm, Manfred |m 1068082259:Volm, Manfred |d 50000 |e 50000PV1068082259 |k 0/50000/ |p 4 |y j | ||
| 998 | |g 120706385 |a Herfarth, Christian |m 120706385:Herfarth, Christian |d 910000 |d 910200 |e 910000PH120706385 |e 910200PH120706385 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 1043912606 |a Kallinowski, Friedrich |m 1043912606:Kallinowski, Friedrich |d 910000 |d 910200 |e 910000PK1043912606 |e 910200PK1043912606 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 1027036945 |a Mattern, Jürgen |m 1027036945:Mattern, Jürgen |d 50000 |e 50000PM1027036945 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1933593881 |e 4759134824 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Mattern","given":"Jürgen","roleDisplay":"VerfasserIn","display":"Mattern, Jürgen","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Kallinowski, Friedrich","given":"Friedrich","family":"Kallinowski"},{"given":"Christian","family":"Herfarth","role":"aut","display":"Herfarth, Christian","roleDisplay":"VerfasserIn"},{"role":"aut","display":"Volm, Manfred","roleDisplay":"VerfasserIn","given":"Manfred","family":"Volm"}],"title":[{"title_sort":"Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer","title":"Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancer"}],"language":["eng"],"recId":"1933593881","type":{"bibl":"article-journal","media":"Online-Ressource"},"note":["Elektronische Reproduktion der Druck-Ausgabe 6. Dezember 1998","Gesehen am 20.08.2025"],"name":{"displayForm":["Jürgen Mattern, Friedrich Kallinowski, Christian Herfarth, Manfred Volm"]},"id":{"eki":["1933593881"],"doi":["10.1002/(SICI)1097-0215(19960703)67:1<20::AID-IJC5>3.0.CO;2-1"]},"origin":[{"dateIssuedDisp":"3 July 1996","dateIssuedKey":"1996"}],"relHost":[{"title":[{"title_sort":"International journal of cancer","title":"International journal of cancer","subtitle":"publication of the International Union against Cancer (UICC) = Journal international du cancer"}],"titleTranslated":[{"translated":"Journal international du cancer"}],"pubHistory":["1.1966 -"],"part":{"year":"1996","issue":"1","pages":"20-23","text":"67(1996), 1, Seite 20-23","volume":"67","extent":"4"},"titleAlt":[{"title":"Predictive oncology"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Association of resistance-related protein expression with poor vascularization and low levels of oxygen in human rectal cancerInternational journal of cancer","note":["Gesehen am 28.02.08","Darin: Predictive oncology"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"International Union against Cancer"}],"language":["eng"],"recId":"269532781","origin":[{"dateIssuedDisp":"1966-","dateIssuedKey":"1966","publisher":"Wiley-Liss","publisherPlace":"Bognor Regis"}],"id":{"issn":["1097-0215"],"zdb":["1474822-8"],"doi":["10.1002/(ISSN)1097-0215"],"eki":["269532781"]},"physDesc":[{"extent":"Online-Ressource"}]}],"physDesc":[{"extent":"4 S."}]} | ||
| SRT | |a MATTERNJUEASSOCIATIO3199 | ||