Cytosine deaminase gene as a potential tool for the genetic therapy of colorectal cancer
The bacterial enzyme cytosine deaminase (CD) catalyzes the conversion of 5-fluorocytosine (5-FC) to the lethal 5-fluorouracil (5-FU) and so provides a useful system for selective killing of gene-modified mammalian tumor cells. Cloning of the CD gene from Escherichia coli and expression in human tumo...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
January 1996
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| In: |
Journal of surgical oncology
Year: 1996, Volume: 61, Issue: 1, Pages: 42-48 |
| ISSN: | 1096-9098 |
| DOI: | 10.1002/(SICI)1096-9098(199601)61:1<42::AID-JSO10>3.0.CO;2-Z |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/(SICI)1096-9098(199601)61:1<42::AID-JSO10>3.0.CO;2-Z Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/%28SICI%291096-9098%28199601%2961%3A1%3C42%3A%3AAID-JSO10%3E3.0.CO%3B2-Z 
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| Author Notes: | Simon Rowley, Marcus Lindauer, Johannes F. Gebert, Uwe Haberkorn, Franz Oberdorfer, Ulrich Moebius, Christian Herfarth, Hans-Konrad Schackert |
MARC
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| 520 | |a The bacterial enzyme cytosine deaminase (CD) catalyzes the conversion of 5-fluorocytosine (5-FC) to the lethal 5-fluorouracil (5-FU) and so provides a useful system for selective killing of gene-modified mammalian tumor cells. Cloning of the CD gene from Escherichia coli and expression in human tumor cell lines enabled these cells to convert 3H-labeled 5-FC into 3H-5-FU. Two CD-expressing human tumor cell lines (adenocarcinoma cell line KM12 and glioblastoma cell line T1115) became 200-fold more sensitive to 5-FC than the nonexpressing parental cell lines. At least 90% of the cells are killed within 7 days. CD-expressing cells are able to kill nonexpressing cells when grown in the same culture flask (bystander effect). The CD gene may be used as a suicide system for in situ chemotherapy or as a safety mechanism abrogating the expression of other genes. © 1996 Wiley-Liss, Inc. | ||
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