Buchumschlag

Construction of a compound model to enhance the accuracy of hepatic fat fraction estimation with quantitative ultrasound$ Boglárka Zsély, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, and Pál Novák Kaposi

Background: we evaluated regression models based on quantitative ultrasound (QUS) parameters and compared them with a vendor-provided method for calculating the ultrasound fat fraction (USFF) in metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: We measured the attenuation co...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zsély, Boglárka (VerfasserIn) , Zsombor, Zita (VerfasserIn) , Rónaszéki, Aladár D. (VerfasserIn) , Egresi, Anna (VerfasserIn) , Stollmayer, Róbert (VerfasserIn) , Himsel, Marco (VerfasserIn) , Bérczi, Viktor (VerfasserIn) , Kalina, Ildikó (VerfasserIn) , Werling, Klára (VerfasserIn) , Győri, Gabriella (VerfasserIn) , Maurovich-Horvat, Pál (VerfasserIn) , Folhoffer, Anikó (VerfasserIn) , Hagymási, Krisztina (VerfasserIn) , Kaposi, Pál Novák (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 17 January 2025
In: Diagnostics
Year: 2025, Jahrgang: 15, Heft: 2, Pages: 1-16
ISSN:2075-4418
DOI:10.3390/diagnostics15020203
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/diagnostics15020203
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2075-4418/15/2/203
Volltext

MARC

LEADER 00000naa a2200000 c 4500
001 1934672866
003 DE-627
005 20250825193944.0
007 cr uuu---uuuuu
008 250825s2025 xx |||||o 00| ||eng c
024 7 |a 10.3390/diagnostics15020203  |2 doi 
035 |a (DE-627)1934672866 
035 |a (DE-599)KXP1934672866 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Zsély, Boglárka  |e VerfasserIn  |0 (DE-588)1374741337  |0 (DE-627)1934672912  |4 aut 
245 1 0 |a Construction of a compound model to enhance the accuracy of hepatic fat fraction estimation with quantitative ultrasound$ Boglárka Zsély, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, and Pál Novák Kaposi 
264 1 |c 17 January 2025 
300 |b Illustrationen 
300 |a 16 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 25.08.2025 
520 |a Background: we evaluated regression models based on quantitative ultrasound (QUS) parameters and compared them with a vendor-provided method for calculating the ultrasound fat fraction (USFF) in metabolic dysfunction-associated steatotic liver disease (MASLD). Methods: We measured the attenuation coefficient (AC) and the backscatter-distribution coefficient (BSC-D) and determined the USFF during a liver ultrasound and calculated the magnetic resonance imaging proton-density fat fraction (MRI-PDFF) and steatosis grade (S0-S4) in a combined retrospective-prospective cohort. We trained multiple models using single or various QUS parameters as independent variables to forecast MRI-PDFF. Linear and nonlinear models were trained during five-time repeated three-fold cross-validation in a retrospectively collected dataset of 60 MASLD cases. We calculated the models’ Pearson correlation (r) and the intraclass correlation coefficient (ICC) in a prospectively collected test set of 57 MASLD cases. Results: The linear multivariable model (r = 0.602, ICC = 0.529) and USFF (r = 0.576, ICC = 0.54) were more reliable in S0- and S1-grade steatosis than the nonlinear multivariable model (r = 0.492, ICC = 0.461). In S2 and S3 grades, the nonlinear multivariable (r = 0.377, ICC = 0.32) and AC-only (r = 0.375, ICC = 0.313) models’ approximated correlation and agreement surpassed that of the multivariable linear model (r = 0.394, ICC = 0.265). We searched a QUS parameter grid to find the optimal thresholds (AC ≥ 0.84 dB/cm/MHz, BSC-D ≥ 105), above which switching from a linear (r = 0.752, ICC = 0.715) to a nonlinear multivariable (r = 0.719, ICC = 0.641) model could improve the overall fit (r = 0.775, ICC = 0.718). Conclusions: The USFF and linear multivariable models are robust in diagnosing low-grade steatosis. Switching to a nonlinear model could enhance the fit to MRI-PDFF in advanced steatosis. 
650 4 |a fatty liver 
650 4 |a magnetic resonance imaging proton-density fat fraction 
650 4 |a metabolic dysfunction-associated steatotic liver disease 
650 4 |a regression analysis 
650 4 |a ultrasound fat fraction (USFF) 
700 1 |a Zsombor, Zita  |e VerfasserIn  |4 aut 
700 1 |a Rónaszéki, Aladár D.  |e VerfasserIn  |4 aut 
700 1 |a Egresi, Anna  |e VerfasserIn  |4 aut 
700 1 |a Stollmayer, Róbert  |e VerfasserIn  |0 (DE-588)1345106033  |0 (DE-627)1905866100  |4 aut 
700 1 |a Himsel, Marco  |e VerfasserIn  |4 aut 
700 1 |a Bérczi, Viktor  |e VerfasserIn  |4 aut 
700 1 |a Kalina, Ildikó  |e VerfasserIn  |4 aut 
700 1 |a Werling, Klára  |e VerfasserIn  |4 aut 
700 1 |a Győri, Gabriella  |e VerfasserIn  |4 aut 
700 1 |a Maurovich-Horvat, Pál  |e VerfasserIn  |4 aut 
700 1 |a Folhoffer, Anikó  |e VerfasserIn  |4 aut 
700 1 |a Hagymási, Krisztina  |e VerfasserIn  |4 aut 
700 1 |a Kaposi, Pál Novák  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Diagnostics  |d Basel : MDPI, 2011  |g 15(2025), 2, Artikel-ID 203, Seite 1-16  |h Online-Ressource  |w (DE-627)718627814  |w (DE-600)2662336-5  |w (DE-576)365413917  |x 2075-4418  |7 nnas  |a Construction of a compound model to enhance the accuracy of hepatic fat fraction estimation with quantitative ultrasound$ Boglárka Zsély, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, and Pál Novák Kaposi 
773 1 8 |g volume:15  |g year:2025  |g number:2  |g elocationid:203  |g pages:1-16  |g extent:16  |a Construction of a compound model to enhance the accuracy of hepatic fat fraction estimation with quantitative ultrasound$ Boglárka Zsély, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, and Pál Novák Kaposi 
856 4 0 |u https://doi.org/10.3390/diagnostics15020203  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.mdpi.com/2075-4418/15/2/203  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20250825 
993 |a Article 
994 |a 2025 
998 |g 1345106033  |a Stollmayer, Róbert  |m 1345106033:Stollmayer, Róbert  |d 910000  |d 911400  |e 910000PS1345106033  |e 911400PS1345106033  |k 0/910000/  |k 1/910000/911400/  |p 5 
999 |a KXP-PPN1934672866  |e 4763982419 
BIB |a Y 
SER |a journal 
JSO |a {"language":["eng"],"relHost":[{"pubHistory":["1.2011 -"],"part":{"extent":"16","volume":"15","text":"15(2025), 2, Artikel-ID 203, Seite 1-16","pages":"1-16","issue":"2","year":"2025"},"note":["Gesehen am 28.05.2020"],"disp":"Construction of a compound model to enhance the accuracy of hepatic fat fraction estimation with quantitative ultrasound$ Boglárka Zsély, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, and Pál Novák KaposiDiagnostics","type":{"media":"Online-Ressource","bibl":"periodical"},"recId":"718627814","language":["eng"],"title":[{"title_sort":"Diagnostics","subtitle":"open access journal","title":"Diagnostics"}],"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"2011-","publisher":"MDPI","dateIssuedKey":"2011","publisherPlace":"Basel"}],"id":{"eki":["718627814"],"zdb":["2662336-5"],"issn":["2075-4418"]}}],"recId":"1934672866","physDesc":[{"extent":"16 S.","noteIll":"Illustrationen"}],"note":["Gesehen am 25.08.2025"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.3390/diagnostics15020203"],"eki":["1934672866"]},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"17 January 2025"}],"title":[{"title":"Construction of a compound model to enhance the accuracy of hepatic fat fraction estimation with quantitative ultrasound$ Boglárka Zsély, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, and Pál Novák Kaposi","title_sort":"Construction of a compound model to enhance the accuracy of hepatic fat fraction estimation with quantitative ultrasound$ Boglárka Zsély, Zita Zsombor, Aladár D. Rónaszéki, Anna Egresi, Róbert Stollmayer, Marco Himsel, Viktor Bérczi, Ildikó Kalina, Klára Werling, Gabriella Győri, Pál Maurovich-Horvat, Anikó Folhoffer, Krisztina Hagymási, and Pál Novák Kaposi"}],"person":[{"role":"aut","display":"Zsély, Boglárka","roleDisplay":"VerfasserIn","given":"Boglárka","family":"Zsély"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Zsombor, Zita","given":"Zita","family":"Zsombor"},{"roleDisplay":"VerfasserIn","display":"Rónaszéki, Aladár D.","role":"aut","family":"Rónaszéki","given":"Aladár D."},{"display":"Egresi, Anna","roleDisplay":"VerfasserIn","role":"aut","family":"Egresi","given":"Anna"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Stollmayer, Róbert","given":"Róbert","family":"Stollmayer"},{"family":"Himsel","given":"Marco","roleDisplay":"VerfasserIn","display":"Himsel, Marco","role":"aut"},{"role":"aut","display":"Bérczi, Viktor","roleDisplay":"VerfasserIn","given":"Viktor","family":"Bérczi"},{"family":"Kalina","given":"Ildikó","display":"Kalina, Ildikó","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Werling","given":"Klára","roleDisplay":"VerfasserIn","display":"Werling, Klára","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Győri, Gabriella","role":"aut","family":"Győri","given":"Gabriella"},{"roleDisplay":"VerfasserIn","display":"Maurovich-Horvat, Pál","role":"aut","family":"Maurovich-Horvat","given":"Pál"},{"family":"Folhoffer","given":"Anikó","roleDisplay":"VerfasserIn","display":"Folhoffer, Anikó","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Hagymási, Krisztina","given":"Krisztina","family":"Hagymási"},{"given":"Pál Novák","family":"Kaposi","role":"aut","display":"Kaposi, Pál Novák","roleDisplay":"VerfasserIn"}]} 
SRT |a ZSELYBOGLACONSTRUCTI1720 

Ähnliche Einträge