Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C
Signal transduction of a human follicular thyroid cancer cell line (FTC133) was investigated. The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%. TSH and EGF stimulated invasion of FTC133...
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| Hauptverfasser: | , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
28 October 1997
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| In: |
Cancer letters
Year: 1997, Jahrgang: 119, Heft: 1, Pages: 1-5 |
| ISSN: | 1872-7980 |
| DOI: | 10.1016/S0304-3835(97)00242-5 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0304-3835(97)00242-5 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304383597002425 
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| Verfasserangaben: | Thomas Hoelting, Quan-Yang Duh, Orlo H. Clark, Christian Herfarth |
| Zusammenfassung: | Signal transduction of a human follicular thyroid cancer cell line (FTC133) was investigated. The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%. TSH and EGF stimulated invasion of FTC133. Antagonism of PKC reversed TSH-mediated stimulation, whereas it had no effect on EGF-stimulation. Our data provide evidence for an essential role of PKC in signal transduction of invasive thyroid cancer. |
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| Beschreibung: | Elektronische Reproduktion der Druck-Ausgabe 5. Januar 1998 Gesehen am 26.08.2025 |
| Beschreibung: | Online Resource |
| ISSN: | 1872-7980 |
| DOI: | 10.1016/S0304-3835(97)00242-5 |