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Invasion of metastatic human follicular thyroid cancer is inhibited via antagonism of protein kinase C

Signal transduction of a human follicular thyroid cancer cell line (FTC133) was investigated. The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%. TSH and EGF stimulated invasion of FTC133...

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Hauptverfasser: Hölting, Thomas (VerfasserIn) , Duh, Quan-Yang (VerfasserIn) , Clark, Orlo H. (VerfasserIn) , Herfarth, Christian (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 28 October 1997
In: Cancer letters
Year: 1997, Jahrgang: 119, Heft: 1, Pages: 1-5
ISSN:1872-7980
DOI:10.1016/S0304-3835(97)00242-5
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0304-3835(97)00242-5
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0304383597002425
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Verfasserangaben:Thomas Hoelting, Quan-Yang Duh, Orlo H. Clark, Christian Herfarth

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520 |a Signal transduction of a human follicular thyroid cancer cell line (FTC133) was investigated. The protein kinase C (PKC)-agonist TPA enhanced invasion by 15%, whereas its antagonists staurosporine, chelerythrine and calphostin C were inhibiting by up to 62%. TSH and EGF stimulated invasion of FTC133. Antagonism of PKC reversed TSH-mediated stimulation, whereas it had no effect on EGF-stimulation. Our data provide evidence for an essential role of PKC in signal transduction of invasive thyroid cancer. 
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