Insights into heart-tumor interactions in heart failure
Heart failure (HF) often coexists with cancer. Beyond the known cardiotoxicity of some cancer treatments, HF itself has been associated with increased cancer incidence. The 2 conditions share common risk factors, mechanisms, and interactions that can worsen patient outcomes. The bidirectional relati...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
May 2025
|
| In: |
Circulation research
Year: 2025, Jahrgang: 136, Heft: 11, Pages: 1262-1285 |
| ISSN: | 1524-4571 |
| DOI: | 10.1161/CIRCRESAHA.124.325490 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/CIRCRESAHA.124.325490 Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.325490 
|
| Verfasserangaben: | Tal Caller, Kathryn J. Moore, Lorenz H. Lehmann, Sean M. Wu, Jonathan Leor |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1935221957 | ||
| 003 | DE-627 | ||
| 005 | 20250903092408.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250903s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1161/CIRCRESAHA.124.325490 |2 doi | |
| 035 | |a (DE-627)1935221957 | ||
| 035 | |a (DE-599)KXP1935221957 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Caller, Tal |e VerfasserIn |0 (DE-588)1375380575 |0 (DE-627)1935222317 |4 aut | |
| 245 | 1 | 0 | |a Insights into heart-tumor interactions in heart failure |c Tal Caller, Kathryn J. Moore, Lorenz H. Lehmann, Sean M. Wu, Jonathan Leor |
| 264 | 1 | |c May 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 24 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 22. Mai 2025 | ||
| 500 | |a Gesehen am 03.09.2025 | ||
| 520 | |a Heart failure (HF) often coexists with cancer. Beyond the known cardiotoxicity of some cancer treatments, HF itself has been associated with increased cancer incidence. The 2 conditions share common risk factors, mechanisms, and interactions that can worsen patient outcomes. The bidirectional relationship between HF and cancer presents a complex interplay of factors that are not fully understood. Recent preclinical evidence suggests that HF may promote tumor growth via the release of protumorigenic factors from the injured heart, revealing HF as a potentially protumorigenic condition. Our review discusses the biological crosstalk between HF and cancer, emphasizing the impact of HF on tumor growth, with inflammation, and modulating the immune system as central mechanisms. We further explore the clinical implications of this connection and propose future research directions. Understanding the mechanistic overlap and interactions between HF and cancer could lead to new biomarkers and therapies, addressing the growing prevalence of both conditions and enhancing approaches to diagnosis, prevention, and treatment. | ||
| 700 | 1 | |a Moore, Kathryn J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lehmann, Lorenz |d 1980- |e VerfasserIn |0 (DE-588)131855212 |0 (DE-627)515807184 |0 (DE-576)298796104 |4 aut | |
| 700 | 1 | |a Wu, Sean M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Leor, Jonathan |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Circulation research |d New York, NY : Assoc., 1953 |g 136(2025), 11, Seite 1262-1285 |h Online-Ressource |w (DE-627)266880126 |w (DE-600)1467838-X |w (DE-576)075145766 |x 1524-4571 |7 nnas |a Insights into heart-tumor interactions in heart failure |
| 773 | 1 | 8 | |g volume:136 |g year:2025 |g number:11 |g pages:1262-1285 |g extent:24 |a Insights into heart-tumor interactions in heart failure |
| 856 | 4 | 0 | |u https://doi.org/10.1161/CIRCRESAHA.124.325490 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.124.325490 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250903 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 131855212 |a Lehmann, Lorenz |m 131855212:Lehmann, Lorenz |d 910000 |d 910100 |d 50000 |e 910000PL131855212 |e 910100PL131855212 |e 50000PL131855212 |k 0/910000/ |k 1/910000/910100/ |k 0/50000/ |p 3 | ||
| 999 | |a KXP-PPN1935221957 |e 476718150X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"name":{"displayForm":["Tal Caller, Kathryn J. Moore, Lorenz H. Lehmann, Sean M. Wu, Jonathan Leor"]},"title":[{"title_sort":"Insights into heart-tumor interactions in heart failure","title":"Insights into heart-tumor interactions in heart failure"}],"recId":"1935221957","relHost":[{"disp":"Insights into heart-tumor interactions in heart failureCirculation research","title":[{"title":"Circulation research","subtitle":"an official journal of the American Heart Association","title_sort":"Circulation research"}],"recId":"266880126","corporate":[{"roleDisplay":"Herausgebendes Organ","display":"American Heart Association","role":"isb"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"pubHistory":["1.1953 -"],"part":{"year":"2025","text":"136(2025), 11, Seite 1262-1285","pages":"1262-1285","extent":"24","issue":"11","volume":"136"},"note":["Gesehen am 09.08.2019"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1524-4571"],"eki":["266880126"],"zdb":["1467838-X"]},"origin":[{"publisherPlace":"New York, NY","dateIssuedDisp":"1953-","publisher":"Assoc.","dateIssuedKey":"1953"}]}],"id":{"eki":["1935221957"],"doi":["10.1161/CIRCRESAHA.124.325490"]},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"May 2025"}],"person":[{"given":"Tal","role":"aut","display":"Caller, Tal","family":"Caller","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Moore","given":"Kathryn J.","display":"Moore, Kathryn J.","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Lehmann","role":"aut","display":"Lehmann, Lorenz","given":"Lorenz"},{"role":"aut","display":"Wu, Sean M.","given":"Sean M.","roleDisplay":"VerfasserIn","family":"Wu"},{"display":"Leor, Jonathan","role":"aut","given":"Jonathan","roleDisplay":"VerfasserIn","family":"Leor"}],"note":["Online veröffentlicht: 22. Mai 2025","Gesehen am 03.09.2025"],"physDesc":[{"noteIll":"Illustrationen","extent":"24 S."}]} | ||
| SRT | |a CALLERTALMINSIGHTSIN2025 | ||