Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemia
In this study we investigated the influence of N-acetylcysteine (NAC) on the hepatic microcirculation after warm ischemia by intravital fluorescence microscopy. Clamping of the left liver lobe was performed in 20 male Wistar rats for 70 min. The treatment group (n = 10) received 400 mg NAC/kg body w...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
1996
|
| In: |
European surgical research
Year: 1996, Jahrgang: 28, Heft: 4, Pages: 270-277 |
| ISSN: | 1421-9921 |
| DOI: | 10.1159/000129466 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000129466
|
| Verfasserangaben: | T.A. Koeppel, J.C. Thies, T. Lehmann, M.M. Gebhard, C. Herfarth, G. Otto, S. Post |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1935230220 | ||
| 003 | DE-627 | ||
| 005 | 20250903105932.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250903s1996 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1159/000129466 |2 doi | |
| 035 | |a (DE-627)1935230220 | ||
| 035 | |a (DE-599)KXP1935230220 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Koeppel, Thomas |e VerfasserIn |0 (DE-588)1076689701 |0 (DE-627)835259889 |0 (DE-576)189152613 |4 aut | |
| 245 | 1 | 0 | |a Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemia |c T.A. Koeppel, J.C. Thies, T. Lehmann, M.M. Gebhard, C. Herfarth, G. Otto, S. Post |
| 264 | 1 | |c 1996 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Elektronische Reproduktion der Druck-Ausgabe 24. April 2008 | ||
| 500 | |a Gesehen am 03.09.2025 | ||
| 520 | |a In this study we investigated the influence of N-acetylcysteine (NAC) on the hepatic microcirculation after warm ischemia by intravital fluorescence microscopy. Clamping of the left liver lobe was performed in 20 male Wistar rats for 70 min. The treatment group (n = 10) received 400 mg NAC/kg body weight 20 min prior to clamping. After reperfusion, acinar and sinusoidal perfusions were observed as well as the leukocyte-endothelium interaction. Phagocytic activity was assessed after application of latex beads. NAC reduced the number of nonperfused sinusoids in all acinar zones. A reduction in zone (portal) was achieved from 15.5 to 7. l%(p < 0.0001), in zone (midzonal) from 14.6 to 6.1% (p < 0.0001) and in zone 3 (central) from 11.9 to 2.9% (p < 0.0001). There were no significant differences in leukocyte adherence as well as in phagocytic activity detectable. We conclude that NAC improves hepatic microcirculation after warm ischemia by increasing sinusoidal blood flow. | ||
| 700 | 1 | |a Thies, Jochen |e VerfasserIn |0 (DE-588)1082449903 |0 (DE-627)847509532 |0 (DE-576)455438854 |4 aut | |
| 700 | 1 | |a Lehmann, Thorsten G. |d 1965- |e VerfasserIn |0 (DE-588)113990170 |0 (DE-627)481946268 |0 (DE-576)174654073 |4 aut | |
| 700 | 1 | |a Gebhard, Martha-Maria |d 1948- |e VerfasserIn |0 (DE-588)1076763278 |0 (DE-627)835312879 |0 (DE-576)445612789 |4 aut | |
| 700 | 1 | |a Herfarth, Christian |d 1933-2014 |e VerfasserIn |0 (DE-588)120706385 |0 (DE-627)080841562 |0 (DE-576)213333414 |4 aut | |
| 700 | 1 | |a Otto, Gerd |d 1944- |e VerfasserIn |0 (DE-588)1235891895 |0 (DE-627)1761126156 |4 aut | |
| 700 | 1 | |a Post, Stefan |d 1954- |e VerfasserIn |0 (DE-588)1026227518 |0 (DE-627)726294667 |0 (DE-576)371524598 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European surgical research |d Basel [u.a.] : Karger, 1969 |g 28(1996), 4, Seite 270-277 |h Online-Ressource |w (DE-627)266886353 |w (DE-600)1468505-X |w (DE-576)109716213 |x 1421-9921 |7 nnas |a Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemia |
| 773 | 1 | 8 | |g volume:28 |g year:1996 |g number:4 |g pages:270-277 |g extent:8 |a Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemia |
| 856 | 4 | 0 | |u https://doi.org/10.1159/000129466 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250903 | ||
| 994 | |a 1996 | ||
| 998 | |g 1026227518 |a Post, Stefan |m 1026227518:Post, Stefan |d 910000 |d 910200 |e 910000PP1026227518 |e 910200PP1026227518 |k 0/910000/ |k 1/910000/910200/ |p 7 |y j | ||
| 998 | |g 1235891895 |a Otto, Gerd |m 1235891895:Otto, Gerd |d 910000 |d 910200 |e 910000PO1235891895 |e 910200PO1235891895 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 120706385 |a Herfarth, Christian |m 120706385:Herfarth, Christian |d 910000 |d 910200 |e 910000PH120706385 |e 910200PH120706385 |k 0/910000/ |k 1/910000/910200/ |p 5 | ||
| 998 | |g 1076763278 |a Gebhard, Martha-Maria |m 1076763278:Gebhard, Martha-Maria |d 910000 |d 910200 |e 910000PG1076763278 |e 910200PG1076763278 |k 0/910000/ |k 1/910000/910200/ |p 4 | ||
| 998 | |g 113990170 |a Lehmann, Thorsten G. |m 113990170:Lehmann, Thorsten G. |d 910000 |d 910200 |e 910000PL113990170 |e 910200PL113990170 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 1082449903 |a Thies, Jochen |m 1082449903:Thies, Jochen |d 910000 |d 910200 |e 910000PT1082449903 |e 910200PT1082449903 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 1076689701 |a Koeppel, Thomas |m 1076689701:Koeppel, Thomas |d 910000 |d 910200 |e 910000PK1076689701 |e 910200PK1076689701 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1935230220 |e 4767212405 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"relHost":[{"id":{"issn":["1421-9921"],"eki":["266886353"],"zdb":["1468505-X"]},"origin":[{"dateIssuedDisp":"1969-","publisher":"Karger","dateIssuedKey":"1969","publisherPlace":"Basel [u.a.]"}],"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title_sort":"European surgical research","subtitle":"clinical and experimental surgery","title":"European surgical research"}],"part":{"extent":"8","volume":"28","text":"28(1996), 4, Seite 270-277","issue":"4","pages":"270-277","year":"1996"},"pubHistory":["1.1969 -"],"language":["eng"],"recId":"266886353","disp":"Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemiaEuropean surgical research","note":["Gesehen am 28.05.2024","Fortsetzung der Druck-Ausgabe"],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"physDesc":[{"extent":"8 S."}],"id":{"doi":["10.1159/000129466"],"eki":["1935230220"]},"origin":[{"dateIssuedKey":"1996","dateIssuedDisp":"1996"}],"name":{"displayForm":["T.A. Koeppel, J.C. Thies, T. Lehmann, M.M. Gebhard, C. Herfarth, G. Otto, S. Post"]},"recId":"1935230220","language":["eng"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Elektronische Reproduktion der Druck-Ausgabe 24. April 2008","Gesehen am 03.09.2025"],"title":[{"title":"Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemia","title_sort":"Improvement of hepatic microhemodynamics by n-acetylcysteine after warm ischemia"}],"person":[{"family":"Koeppel","given":"Thomas","display":"Koeppel, Thomas","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Thies, Jochen","roleDisplay":"VerfasserIn","role":"aut","family":"Thies","given":"Jochen"},{"roleDisplay":"VerfasserIn","display":"Lehmann, Thorsten G.","role":"aut","family":"Lehmann","given":"Thorsten G."},{"family":"Gebhard","given":"Martha-Maria","roleDisplay":"VerfasserIn","display":"Gebhard, Martha-Maria","role":"aut"},{"given":"Christian","family":"Herfarth","role":"aut","roleDisplay":"VerfasserIn","display":"Herfarth, Christian"},{"role":"aut","display":"Otto, Gerd","roleDisplay":"VerfasserIn","given":"Gerd","family":"Otto"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Post, Stefan","given":"Stefan","family":"Post"}]} | ||
| SRT | |a KOEPPELTHOIMPROVEMEN1996 | ||