Dose-intensified SBRT for vertebral oligometastases: results from a prospective clinical trial
Purpose - To prospectively evaluate safety and efficacy of dose-intensified multifraction SBRT using a simultaneous-integrated boost concept for vertebral oligometastases. - Material and Methods - Data from 128 patients with 143 vertebral oligometastases (≤5 distant metastases in total) treated with...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2025
|
| In: |
Radiotherapy and oncology
Year: 2025, Jahrgang: 208, Pages: 1-7 |
| ISSN: | 1879-0887 |
| DOI: | 10.1016/j.radonc.2025.110940 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.radonc.2025.110940 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S016781402500235X 
|
| Verfasserangaben: | Matthias Guckenberger, Lotte Wilke, Charlotte Billiet, Susanne Rogers, Ciro Franzese, Daniel Schnell, Mateusz Spałek, Daniel M. Aebersold, Hossein Hemmatazad, Thomas Zilli, Judit Boda-Heggemann, Brigitta G. Baumert, Jean-Jacques Stelmes, Franziska Nägler, Philipp Gut, Christian Weiß, Alessio Bruni, Frank Zimmermann, Robert Förster, Jörg Zimmer, Indira Madani |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1935269143 | ||
| 003 | DE-627 | ||
| 005 | 20251023214621.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250904s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.radonc.2025.110940 |2 doi | |
| 035 | |a (DE-627)1935269143 | ||
| 035 | |a (DE-599)KXP1935269143 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Guckenberger, Matthias |d 1976- |e VerfasserIn |0 (DE-588)129124656 |0 (DE-627)389671487 |0 (DE-576)297505963 |4 aut | |
| 245 | 1 | 0 | |a Dose-intensified SBRT for vertebral oligometastases |b results from a prospective clinical trial |c Matthias Guckenberger, Lotte Wilke, Charlotte Billiet, Susanne Rogers, Ciro Franzese, Daniel Schnell, Mateusz Spałek, Daniel M. Aebersold, Hossein Hemmatazad, Thomas Zilli, Judit Boda-Heggemann, Brigitta G. Baumert, Jean-Jacques Stelmes, Franziska Nägler, Philipp Gut, Christian Weiß, Alessio Bruni, Frank Zimmermann, Robert Förster, Jörg Zimmer, Indira Madani |
| 264 | 1 | |c July 2025 | |
| 300 | |b Diagramme | ||
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 14. Mai 2025, Artikelversion: 24. Mai 2025 | ||
| 500 | |a Gesehen am 04.09.2025 | ||
| 520 | |a Purpose - To prospectively evaluate safety and efficacy of dose-intensified multifraction SBRT using a simultaneous-integrated boost concept for vertebral oligometastases. - Material and Methods - Data from 128 patients with 143 vertebral oligometastases (≤5 distant metastases in total) treated with dose-intensified SBRT (48.5 Gy/10 [with epidural involvement] or 40 Gy/5 [without epidural involvement]) in the randomized and non-randomized arms of a phase 3 clinical trial conducted at 18 international centers between 2016 and 2023 were analyzed. - Results - The median age of all patients was 68 years; 77 patients (60.2%) had breast and prostate cancer. Of 143 vertebral metastases, 23 (16.1%) and 22 metastases (15.4%) had epidural and paraspinal tumor involvement, respectively. The median follow-up time was 24 months. At 2 years, cumulative incidence of local failure (4 failures) was 5.3%. There were 4 (2.8%) baseline and 8 (5.6%) de novo vertebral compression fractures (VCFs). Two-year OS was 82.2% (95% CI, 74.9-89.6%). There was no grade ≥ 4 adverse events (AE) and the crude rate of grade 3 AEs was 5.5%; no myelopathy or plexopathy was observed. On multivariate analysis, only non-breast or non-prostate cancer (HR, 7.91; 95%, CI 1.79-35.03; 2-sided P = 0.01) were found to be prognostic for adverse OS. No prognostic factors for VCF were identified. Epidural and paraspinal involvement were not found to be prognostic for treatment outcome. - Conclusions - Dose-intensified SBRT for vertebral oligometastases is effective and safe, even in high-risk patients with epidural or paraspinal involvement. | ||
| 650 | 4 | |a Local failure | |
| 650 | 4 | |a Oligometastases | |
| 650 | 4 | |a SBRT | |
| 650 | 4 | |a Vertebral compression fracture | |
| 650 | 4 | |a Vertebral metastases | |
| 700 | 1 | |a Wilke, Lotte |e VerfasserIn |4 aut | |
| 700 | 1 | |a Billiet, Charlotte |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rogers, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Franzese, Ciro |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Schnell, Daniel |e VerfasserIn |0 (DE-588)113208461X |0 (DE-627)887360750 |0 (DE-576)488602742 |4 aut | |
| 700 | 1 | |a Spałek, Mateusz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Aebersold, Daniel M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hemmatazad, Hossein |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zilli, Thomas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Boda-Heggemann, Judit |d 1977- |e VerfasserIn |0 (DE-588)1029853436 |0 (DE-627)734363087 |0 (DE-576)377699411 |4 aut | |
| 700 | 1 | |8 2\p |a Baumert, Brigitta |e VerfasserIn |0 (DE-588)1089251130 |0 (DE-627)853053596 |0 (DE-576)459788302 |4 aut | |
| 700 | 1 | |a Stelmes, Jean-Jacques |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nägler, Franziska |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gut, Philipp |e VerfasserIn |4 aut | |
| 700 | 1 | |a Weiß, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bruni, Alessio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zimmermann, Frank |e VerfasserIn |4 aut | |
| 700 | 1 | |8 3\p |a Förster, Robert |d 1984- |e VerfasserIn |0 (DE-588)1063692660 |0 (DE-627)812495810 |0 (DE-576)422845159 |4 aut | |
| 700 | 1 | |a Zimmer, Jörg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Madani, Indira |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Radiotherapy and oncology |d Amsterdam [u.a.] : Elsevier Science, 1983 |g 208(2025) vom: Juli, Artikel-ID 110940, Seite 1-7 |h Online-Ressource |w (DE-627)306710110 |w (DE-600)1500707-8 |w (DE-576)082435731 |x 1879-0887 |7 nnas |a Dose-intensified SBRT for vertebral oligometastases results from a prospective clinical trial |
| 773 | 1 | 8 | |g volume:208 |g year:2025 |g month:07 |g elocationid:110940 |g pages:1-7 |g extent:7 |a Dose-intensified SBRT for vertebral oligometastases results from a prospective clinical trial |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.radonc.2025.110940 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S016781402500235X |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20251001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20251001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20251001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250904 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1029853436 |a Boda-Heggemann, Judit |m 1029853436:Boda-Heggemann, Judit |d 60000 |d 63000 |d 60000 |e 60000PB1029853436 |e 63000PB1029853436 |e 60000PB1029853436 |k 0/60000/ |k 1/60000/63000/ |k 0/60000/ |p 11 | ||
| 999 | |a KXP-PPN1935269143 |e 4767735874 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"given":"Matthias","role":"aut","family":"Guckenberger","display":"Guckenberger, Matthias"},{"display":"Wilke, Lotte","family":"Wilke","role":"aut","given":"Lotte"},{"role":"aut","given":"Charlotte","display":"Billiet, Charlotte","family":"Billiet"},{"display":"Rogers, Susanne","family":"Rogers","role":"aut","given":"Susanne"},{"role":"aut","given":"Ciro","display":"Franzese, Ciro","family":"Franzese"},{"family":"Schnell","display":"Schnell, Daniel","role":"aut","given":"Daniel"},{"role":"aut","given":"Mateusz","display":"Spałek, Mateusz","family":"Spałek"},{"role":"aut","given":"Daniel M.","family":"Aebersold","display":"Aebersold, Daniel M."},{"display":"Hemmatazad, Hossein","family":"Hemmatazad","given":"Hossein","role":"aut"},{"role":"aut","given":"Thomas","family":"Zilli","display":"Zilli, Thomas"},{"display":"Boda-Heggemann, Judit","family":"Boda-Heggemann","role":"aut","given":"Judit"},{"given":"Brigitta","role":"aut","family":"Baumert","display":"Baumert, Brigitta"},{"given":"Jean-Jacques","role":"aut","family":"Stelmes","display":"Stelmes, Jean-Jacques"},{"role":"aut","given":"Franziska","family":"Nägler","display":"Nägler, Franziska"},{"role":"aut","given":"Philipp","display":"Gut, Philipp","family":"Gut"},{"role":"aut","given":"Christian","family":"Weiß","display":"Weiß, Christian"},{"family":"Bruni","display":"Bruni, Alessio","role":"aut","given":"Alessio"},{"given":"Frank","role":"aut","display":"Zimmermann, Frank","family":"Zimmermann"},{"family":"Förster","display":"Förster, Robert","role":"aut","given":"Robert"},{"given":"Jörg","role":"aut","display":"Zimmer, Jörg","family":"Zimmer"},{"family":"Madani","display":"Madani, Indira","given":"Indira","role":"aut"}],"name":{"displayForm":["Matthias Guckenberger, Lotte Wilke, Charlotte Billiet, Susanne Rogers, Ciro Franzese, Daniel Schnell, Mateusz Spałek, Daniel M. Aebersold, Hossein Hemmatazad, Thomas Zilli, Judit Boda-Heggemann, Brigitta G. Baumert, Jean-Jacques Stelmes, Franziska Nägler, Philipp Gut, Christian Weiß, Alessio Bruni, Frank Zimmermann, Robert Förster, Jörg Zimmer, Indira Madani"]},"physDesc":[{"noteIll":"Diagramme","extent":"7 S."}],"relHost":[{"part":{"volume":"208","extent":"7","text":"208(2025) vom: Juli, Artikel-ID 110940, Seite 1-7","pages":"1-7","year":"2025"},"titleAlt":[{"title":"The green journal"}],"language":["eng"],"id":{"zdb":["1500707-8"],"issn":["1879-0887"],"eki":["306710110"]},"recId":"306710110","physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Dose-intensified SBRT for vertebral oligometastases results from a prospective clinical trialRadiotherapy and oncology","title":[{"title":"Radiotherapy and oncology","subtitle":"journal of the European Society for Therapeutic Radiology and Oncology","title_sort":"Radiotherapy and oncology"}],"pubHistory":["1.1983 -"],"note":["Gesehen am 30.05.15","Ungezählte Beil.: Supplement"],"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1983","publisher":"Elsevier Science","dateIssuedDisp":"1983-"}]}],"recId":"1935269143","id":{"eki":["1935269143"],"doi":["10.1016/j.radonc.2025.110940"]},"origin":[{"dateIssuedDisp":"July 2025","dateIssuedKey":"2025"}],"note":["Online verfügbar: 14. Mai 2025, Artikelversion: 24. Mai 2025","Gesehen am 04.09.2025"],"title":[{"title_sort":"Dose-intensified SBRT for vertebral oligometastases","subtitle":"results from a prospective clinical trial","title":"Dose-intensified SBRT for vertebral oligometastases"}],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a GUCKENBERGDOSEINTENS2025 | ||