Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the rat
Background - Previous reports demonstrated that radiographic contrast medium, as used in contrast-enhanced computed tomography, increases acinar necrosis and mortality in experimental pancreatitis. The authors studed the possibility that these changes may be related to an additional impai...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 1995
|
| In: |
Annals of surgery
Year: 1995, Volume: 221, Issue: 3, Pages: 257-264 |
| ISSN: | 1528-1140 |
| DOI: | 10.1097/00000658-199503000-00007 |
| Online Access: | Verlag: https://doi.org/10.1097/00000658-199503000-00007 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/annalsofsurgery/abstract/1995/03000/intravenous_contrast_medium_aggravates_the.7.aspx 
|
| Author Notes: | Jan Schmidt, Hubert G. Hotz, Thomas Foitzik, Eduard Ryschich, Heinz J. Buhr, Andrew L. Warshaw, Christian Herfarth, Ernst Klar |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1935305670 | ||
| 003 | DE-627 | ||
| 005 | 20250913142005.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250904s1995 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/00000658-199503000-00007 |2 doi | |
| 035 | |a (DE-627)1935305670 | ||
| 035 | |a (DE-599)KXP1935305670 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Schmidt, Jan |d 1961- |e VerfasserIn |0 (DE-588)1022937995 |0 (DE-627)717335852 |0 (DE-576)366198017 |4 aut | |
| 245 | 1 | 0 | |a Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the rat |c Jan Schmidt, Hubert G. Hotz, Thomas Foitzik, Eduard Ryschich, Heinz J. Buhr, Andrew L. Warshaw, Christian Herfarth, Ernst Klar |
| 264 | 1 | |c March 1995 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 04.09.2025 | ||
| 520 | |a Background - Previous reports demonstrated that radiographic contrast medium, as used in contrast-enhanced computed tomography, increases acinar necrosis and mortality in experimental pancreatitis. The authors studed the possibility that these changes may be related to an additional impairment of pancreatic microcirulation. - Methods - Fifty Wistar rats had acute pancreatitis induced by intraductal glycodeoxycholic acid (10 mmol/L for 10 min) and intravenous cerulein (5 μg/kg/hr for 6 hrs). After rehydration (16 mL/kg), pancreatic capillary perfusion was quantified by means of intravital microscopy at baseline before intravenous infusion of contrast medium (n = 25) or saline (n = 25), and 30 and 60 minutes thereafter. In addition to total capillary flow, capillaries were categorized as high-or low-flow (> or <1.6nL/min). - Results - Pancreatic capillary flow did not change in either high- or low-flow capillaries after saline infusion. However, contrast medium infusion induced a significant decrease of total capillary flow (p < 0.001). Analysis according to the relative flow rate revealed that this was primarity because of a significant additional reduction of perfusion in low-flow capillaries (p < 0.0001). Furthermore, complete capillary stasis was observed in 15.9 ± 3.4% after contrast medium as compared with 3.2 ± 1.2% after saline infusion (p < 0.006). - Conclusion - Radiographic contrast medium aggravates the impairment of pancreatic microcirculation in experimental necrotizing pancreatitis. | ||
| 700 | 1 | |a Hotz, Hubert |e VerfasserIn |0 (DE-588)1375549154 |0 (DE-627)1935304690 |4 aut | |
| 700 | 1 | |a Foitzik, Thomas |d 1961- |e VerfasserIn |0 (DE-588)1015287751 |0 (DE-627)705360997 |0 (DE-576)350414467 |4 aut | |
| 700 | 1 | |a Ryschich, Eduard |d 1967- |e VerfasserIn |0 (DE-588)120246546 |0 (DE-627)696498340 |0 (DE-576)292118090 |4 aut | |
| 700 | 1 | |a Buhr, Heinz J. |d 1945- |e VerfasserIn |0 (DE-588)115821767 |0 (DE-627)077495039 |0 (DE-576)174713320 |4 aut | |
| 700 | 1 | |a Warshaw, Andrew L. |d 1939- |e VerfasserIn |0 (DE-588)1156566622 |0 (DE-627)1019365838 |0 (DE-576)502259930 |4 aut | |
| 700 | 1 | |a Herfarth, Christian |d 1933-2014 |e VerfasserIn |0 (DE-588)120706385 |0 (DE-627)080841562 |0 (DE-576)213333414 |4 aut | |
| 700 | 1 | |a Klar, Ernst |d 1952- |e VerfasserIn |0 (DE-588)136455107 |0 (DE-627)582906431 |0 (DE-576)301029326 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of surgery |d [Erscheinungsort nicht ermittelbar] : Lippincott Williams & Wilkins, 1885 |g 221(1995), 3, Seite 257-264 |h Online-Ressource |w (DE-627)313115222 |w (DE-600)2002200-1 |w (DE-576)090881796 |x 1528-1140 |7 nnas |a Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the rat |
| 773 | 1 | 8 | |g volume:221 |g year:1995 |g number:3 |g pages:257-264 |g extent:8 |a Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the rat |
| 856 | 4 | 0 | |u https://doi.org/10.1097/00000658-199503000-00007 |x Verlag |
| 856 | 4 | 0 | |u https://journals.lww.com/annalsofsurgery/abstract/1995/03000/intravenous_contrast_medium_aggravates_the.7.aspx |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250904 | ||
| 993 | |a Article | ||
| 994 | |a 1995 | ||
| 998 | |g 136455107 |a Klar, Ernst |m 136455107:Klar, Ernst |d 910000 |d 910200 |e 910000PK136455107 |e 910200PK136455107 |k 0/910000/ |k 1/910000/910200/ |p 8 |y j | ||
| 998 | |g 120706385 |a Herfarth, Christian |m 120706385:Herfarth, Christian |d 910000 |d 910200 |e 910000PH120706385 |e 910200PH120706385 |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 115821767 |a Buhr, Heinz J. |m 115821767:Buhr, Heinz J. |d 50000 |e 50000PB115821767 |k 0/50000/ |p 5 | ||
| 998 | |g 120246546 |a Ryschich, Eduard |m 120246546:Ryschich, Eduard |d 910000 |d 910200 |e 910000PR120246546 |e 910200PR120246546 |k 0/910000/ |k 1/910000/910200/ |p 4 | ||
| 998 | |g 1015287751 |a Foitzik, Thomas |m 1015287751:Foitzik, Thomas |d 910000 |d 910200 |e 910000PF1015287751 |e 910200PF1015287751 |k 0/910000/ |k 1/910000/910200/ |p 3 | ||
| 998 | |g 1022937995 |a Schmidt, Jan |m 1022937995:Schmidt, Jan |d 910000 |d 910200 |e 910000PS1022937995 |e 910200PS1022937995 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1935305670 |e 4767895642 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"March 1995","dateIssuedKey":"1995"}],"note":["Gesehen am 04.09.2025"],"recId":"1935305670","name":{"displayForm":["Jan Schmidt, Hubert G. Hotz, Thomas Foitzik, Eduard Ryschich, Heinz J. Buhr, Andrew L. Warshaw, Christian Herfarth, Ernst Klar"]},"relHost":[{"origin":[{"dateIssuedKey":"1885","publisherPlace":"[Erscheinungsort nicht ermittelbar] ; [Erscheinungsort nicht ermittelbar]","publisher":"Lippincott Williams & Wilkins ; Ovid","dateIssuedDisp":"1885-"}],"recId":"313115222","part":{"text":"221(1995), 3, Seite 257-264","issue":"3","pages":"257-264","extent":"8","year":"1995","volume":"221"},"pubHistory":["1.1885 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"id":{"zdb":["2002200-1"],"issn":["1528-1140"],"eki":["313115222"]},"disp":"Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the ratAnnals of surgery","note":["Gesehen am 26.09.18"],"title":[{"title":"Annals of surgery","subtitle":"a monthly review of surgical science and practice","title_sort":"Annals of surgery"}],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"]}],"title":[{"title_sort":"Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the rat","title":"Intravenous contrast medium aggravates the impairment of pancreatic microcirculation in necrotizing pancreatitis in the rat"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1097/00000658-199503000-00007"],"eki":["1935305670"]},"physDesc":[{"extent":"8 S."}],"person":[{"family":"Schmidt","given":"Jan","display":"Schmidt, Jan","role":"aut"},{"given":"Hubert","family":"Hotz","role":"aut","display":"Hotz, Hubert"},{"family":"Foitzik","given":"Thomas","display":"Foitzik, Thomas","role":"aut"},{"given":"Eduard","family":"Ryschich","role":"aut","display":"Ryschich, Eduard"},{"role":"aut","display":"Buhr, Heinz J.","given":"Heinz J.","family":"Buhr"},{"role":"aut","display":"Warshaw, Andrew L.","given":"Andrew L.","family":"Warshaw"},{"role":"aut","display":"Herfarth, Christian","given":"Christian","family":"Herfarth"},{"given":"Ernst","family":"Klar","role":"aut","display":"Klar, Ernst"}],"language":["eng"]} | ||
| SRT | |a SCHMIDTJANINTRAVENOU1995 | ||