Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy
Takotsubo cardiomyopathy (TTC) is marked by an acute, transient, and reversible left ventricular systolic dysfunction triggered by stress, with endothelial dysfunction being one of its pathophysiological mechanisms. However, the precise molecular mechanism underlying the interaction between endothel...
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
04 February 2025
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| In: |
Stem cell research & therapy
Year: 2025, Volume: 16, Issue: 1, Pages: 36-1-36-21 |
| ISSN: | 1757-6512 |
| DOI: | 10.1186/s13287-025-04157-0 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13287-025-04157-0
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| Author Notes: | Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, and Ibrahim Akin |
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| 520 | |a Takotsubo cardiomyopathy (TTC) is marked by an acute, transient, and reversible left ventricular systolic dysfunction triggered by stress, with endothelial dysfunction being one of its pathophysiological mechanisms. However, the precise molecular mechanism underlying the interaction between endothelial cells and cardiomyocytes during TTC remains unclear. This study reveals that exosomal miRNAs derived from endothelial cells exposed to catecholamine contribute to ion channel dysfunction in the setting of TTC. | ||
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| 650 | 4 | |a Human-induced pluripotent stem cell-derived cardiomyocytes | |
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| 650 | 4 | |a Takotsubo cardiomyopathy | |
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