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Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy

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Takotsubo cardiomyopathy (TTC) is marked by an acute, transient, and reversible left ventricular systolic dysfunction triggered by stress, with endothelial dysfunction being one of its pathophysiological mechanisms. However, the precise molecular mechanism underlying the interaction between endothel...

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Main Authors: Fan, Xuehui (Author) , Yang, Guoqiang (Author) , Wang, Yinuo (Author) , Shi, Haojie (Author) , Nitschke, Katja (Author) , Sattler, Katherine (Author) , Abumayyaleh, Mohammad S. A. (Author) , Cyganek, Lukas (Author) , Nuhn, Philipp (Author) , Worst, Thomas (Author) , Liao, Bin (Author) , Dobreva, Gergana (Author) , Dürschmied, Daniel (Author) , Zhou, Xiao-Bo (Author) , El-Battrawy, Ibrahim (Author) , Akın, Ibrahim (Author)
Format: Article (Journal)
Language:English
Published: 04 February 2025
In: Stem cell research & therapy
Year: 2025, Volume: 16, Issue: 1, Pages: 36-1-36-21
ISSN:1757-6512
DOI:10.1186/s13287-025-04157-0
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s13287-025-04157-0
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Author Notes:Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, and Ibrahim Akin
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Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Fan, Xuehui (Author) , Yang, Guoqiang (Author) , Wang, Yinuo (Author) , Shi, Haojie (Author) , Nitschke, Katja (Author) , Sattler, Katherine (Author) , Abumayyaleh, Mohammad S. A. (Author) , Cyganek, Lukas (Author) , Nuhn, Philipp (Author) , Worst, Thomas (Author) , Liao, Bin (Author) , Dobreva, Gergana (Author) , Dürschmied, Daniel (Author) , Zhou, Xiao-Bo (Author) , El-Battrawy, Ibrahim (Author) , Akın, Ibrahim (Author) ,


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