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Tailoring the use of central pancreatectomy through prediction models for major morbidity and postoperative diabetes: international retrospective multicenter study

Objective: - To develop a prediction model for major morbidity and endocrine dysfunction after central pancreatectomy (CP) which could help in tailoring the use of this procedure. - Background: - CP is a parenchyma-sparing alternative to distal pancreatectomy for symptomatic benign and premalignan...

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Main Authors: Bodegraven, Eduard A. van (Author) , Lof, Sanne (Author) , Jones, Leia (Author) , Aussilhou, Béatrice (Author) , Yong, Gao (Author) , Jishu, Wei (Author) , Klotz, Rosa (Author) , Rocha-Castellanos, Dario Missael (Author) , Matsumato, Ippei (Author) , de Ponthaud, Charles (Author) , Tanaka, Kimitaka (Author) , Biesel, Esther (Author) , Kauffmann, Emmanuele (Author) , Dumitrascu, Traian (Author) , Nagakawa, Yuichi (Author) , Martí-Cruchaga, Pablo (Author) , Roeyen, Geert (Author) , Zerbi, Alessandro (Author) , Goetz, Mara (Author) , DeMeijer, Vincent E. (Author) , Pessaux, Patrick (Author) , Ignatavicius, Povilas (Author) , Demir, Ihsan Ekin (Author) , Giuffrida, Mario (Author) , Tingstedt, Bobby (Author) , Marino, Marco Vito (Author) , Mastoridis, Sotiris (Author) , Brunner, Maximilian (Author) , Mora-Oliver, Isabel (Author) , Bortolato, Cecilia (Author) , Gulla, Aisté (Author) , Apers, Thomas (Author) , Hermand, Hélène (Author) , Mitsuka, Yusuke (Author) , Popescu, Irinel (Author) , Boggi, Ugo (Author) , Wittel, Uwe Alexander (Author) , Hirano, Satoshi (Author) , Gaujoux, Sébastien (Author) , Kamei, Keiko (Author) , Fernández-Del Castillo, Carlos (Author) , Hackert, Thilo (Author) , Kuirong, Jiang (Author) , Yi, Miao (Author) , Sauvanet, Alain (Author) , Besselink, Marc G. (Author) , Abu Hilal, Mohammad (Author) , Dokmak, Safi (Author)
Format: Article (Journal)
Language:English
Published: December 2024
In: Annals of surgery
Year: 2024, Volume: 280, Pages: 993-998
ISSN:1528-1140
DOI:10.1097/SLA.0000000000006157
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/SLA.0000000000006157
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/annalsofsurgery/fulltext/2024/12000/tailoring_the_use_of_central_pancreatectomy.17.aspx
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Author Notes:Eduard Antonie van Bodegraven, Sanne Lof, Leia Jones, Béatrice Aussilhou, Gao Yong, Wei Jishu, Rosa Klotz, Dario Missael Rocha-Castellanos, Ippei Matsumato, Charles de Ponthaud, Kimitaka Tanaka, Esther Biesel, Emmanuele Kauffmann, Traian Dumitrascu, Yuichi Nagakawa, Pablo Martí-Cruchaga, Geert Roeyen, Alessandro Zerbi, Mara Goetz, Vincent E. de Meijer, Patrick Pessaux, Povilas Ignatavicius, Ihsan Ekin Demir, Mario Giuffrida, Bobby Tingstedt, Marco Vito Marino, Sotiris Mastoridis, Maximilian Brunner, Isabel Mora-Oliver, Cecilia Bortolato, Aisté Gulla, Thomas Apers, Hélène Hermand, Yusuke Mitsuka, Irinel Popescu, Ugo Boggi, Uwe Wittel, Satoshi Hirano, Sébastien Gaujoux, Keiko Kamei, Carlos Fernández-Del Castillo, Thilo Hackert, Jiang Kuirong, Miao Yi, Alain Sauvanet, Marc Besselink, Mohammad Abu Hilal, Safi Dokmak,and for the European Consortium on Minimally Invasive Pancreatic Surgery and the International Consortium on Minimally Invasive Pancreatic Surgery
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Summary:Objective: - To develop a prediction model for major morbidity and endocrine dysfunction after central pancreatectomy (CP) which could help in tailoring the use of this procedure. - Background: - CP is a parenchyma-sparing alternative to distal pancreatectomy for symptomatic benign and premalignant tumors in the body and neck of the pancreas CP lowers the risk of new-onset diabetes and exocrine pancreatic insufficiency compared with distal pancreatectomy but it is thought to increase the risk of short-term complications, including postoperative pancreatic fistula (POPF). - Methods: - International multicenter retrospective cohort study including patients from 51 centers in 19 countries (2010-2021). The primary endpoint was major morbidity. Secondary endpoints included POPF grade B/C, endocrine dysfunction, and the use of pancreatic enzymes. Two risk models were designed for major morbidity and endocrine dysfunction utilizing multivariable logistic regression and internal and external validation. - Results: - A total of 838 patients after CP were included [301 (36%) minimally invasive] and major morbidity occurred in 248 (30%) patients, POPF B/C in 365 (44%), and 30-day mortality in 4 (1%). Endocrine dysfunction in 91 patients (11%) and use of pancreatic enzymes in 108 (12%). The risk model for major morbidity included male sex, age, Body Mass Index, and American Society of Anesthesiologists score ≥3. The model performed acceptably with an area under the curve of 0.72 (CI: 0.68-0.76). The risk model for endocrine dysfunction included higher Body Mass Index and male sex and performed well [area under the curve: 0.83 (CI: 0.77-0.89)]. - Conclusions: - The proposed risk models help in tailoring the use of CP in patients with symptomatic benign and premalignant lesions in the body and neck of the pancreas (readily available through www.pancreascalculator.com).
Item Description:Gesehen am 10.09.2025
Physical Description:Online Resource
ISSN:1528-1140
DOI:10.1097/SLA.0000000000006157

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