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Relationship of choroidal thickness with age-related macular degeneration in Asians: an Asian eye epidemiology consortium meta-analysis

To compare the choroidal thickness (CT) of participants with various stages of age-related macular degeneration vs. normal controls through a meta-analysis of studies conducted within the Asian Eye Epidemiology Consortium. Eight population-based studies from China, Iran, Japan, and Singapore were...

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Hauptverfasser: Sasaki, Mariko (Verfasst von) , Cheong, Kai Xiong (Verfasst von) , Chong, Crystal Chun Yuen (Verfasst von) , Yu, Marco (Verfasst von) , Hanyuda, Akiko (Verfasst von) , Yuki, Kenya (Verfasst von) , Negishi, Kazuno (Verfasst von) , Hashimoto, Sawako (Verfasst von) , Fujiwara, Kohta (Verfasst von) , Sonoda, Kohei (Verfasst von) , Wang, Ya Xing (Verfasst von) , Gao, Fei (Verfasst von) , Amornpetchsathaporn, Anyarak (Verfasst von) , Chainakul, Methaphon (Verfasst von) , Srinivasan, Ramyaa (Verfasst von) , Khan, Rehana (Verfasst von) , Raman, Rajiv (Verfasst von) , Ruamviboonsuk, Paisan (Verfasst von) , Kim, Sung Ho (Verfasst von) , Song, Su Jeong (Verfasst von) , Emamian, Mohammad Hassan (Verfasst von) , Hashemi, Hassan (Verfasst von) , Fotouhi, Akbar (Verfasst von) , Liu, Juping (Verfasst von) , Li, Xiaorong (Verfasst von) , Jonas, Jost B. (Verfasst von) , Cheung, Chui Ming Gemmy (Verfasst von) , Wong, Tien Yin (Verfasst von) , Cheng, Ching-Yu (Verfasst von) , Tham, Yih Chung (Verfasst von) , Yanagi, Yasuo (Verfasst von) , Tan, Anna Cheng Sim (Verfasst von)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 2025
In: Investigative ophthalmology & visual science
Year: 2025, Jahrgang: 66, Heft: 6, Pages: 1-11
ISSN:1552-5783
DOI:10.1167/iovs.66.6.36
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1167/iovs.66.6.36
Volltext
Verfasserangaben:Mariko Sasaki, Kai Xiong Cheong, Crystal Chun Yuen Chong, Marco Yu, Akiko Hanyuda, Kenya Yuki, Kazuno Negishi, Sawako Hashimoto, Kohta Fujiwara, Kohei Sonoda, Ya Xing Wang, Fei Gao, Anyarak Amornpetchsathaporn, Methaphon Chainakul, Ramyaa Srinivasan, Rehana Khan, Rajiv Raman, Paisan Ruamviboonsuk, Sung Ho Kim, Su Jeong Song, Mohammad Hassan Emamian, Hassan Hashemi, Akbar Fotouhi, Juping Liu, Xiaorong Li, Jost B. Jonas, Chui Ming Gemmy Cheung, Tien Yin Wong, Ching-Yu Cheng, Yih Chung Tham, Yasuo Yanagi and Anna Cheng Sim Tan
Beschreibung
Zusammenfassung:To compare the choroidal thickness (CT) of participants with various stages of age-related macular degeneration vs. normal controls through a meta-analysis of studies conducted within the Asian Eye Epidemiology Consortium. Eight population-based studies from China, Iran, Japan, and Singapore were included. Axial length and spherical equivalent measurements and imaging with color fundus photography and spectral-domain optical coherence tomography were performed. Random-effects meta-analysis was performed to examine the association between AMD and its stages (early AMD, intermediate AMD [iAMD], neovascular AMD [nAMD], and geographic atrophy [GA]) with CT, while adjusting for age, sex, current smoking status, and axial length/spherical equivalent. Of 17,916 participants, 13,116 participants (mean age, 62.15 ± 9.66 years) were included into the study. The mean unadjusted CT was 245.01 ± 84.04 µm (mean CT, 255.4 µm [no AMD], 263.59 µm [early AMD], 270.64 µm [iAMD], 273.32 µm [nAMD], and 156.50 µm [GA]). The presence of AMD was associated with a thicker choroid (β = 11.51; 95% confidence interval [CI], 4.10-18.92). AMD severity was also positively associated with CT. Early AMD (β = 8.75; 95% CI, 0.03-17.47), iAMD (β = 19.68; 95% CI, 13.20-26.16), and nAMD (β = 34.15; 95% CI, 6.84-61.46) were each positively associated with a thicker CT after adjusting for age, sex, smoking, and spherical equivalent. GA was not significantly associated with CT. In a large Asian cohort, AMD is associated with a thicker choroid in early AMD, iAMD, and nAMD, but not in GA. Studying the CT will help to better characterize Asian AMD phenotypes, which may show differences compared with AMD phenotypes in Western populations.
Beschreibung:Online veröffentlicht: 10. Juni 2025
Gesehen am 15.09.2025
Beschreibung:Online Resource
ISSN:1552-5783
DOI:10.1167/iovs.66.6.36

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