Imidazole propionate is a driver and therapeutic target in atherosclerosis
Atherosclerosis is the main underlying cause of cardiovascular diseases. Its prevention is based on the detection and treatment of traditional cardiovascular risk factors1. However, individuals at risk for early vascular disease often remain unidentified2. Recent research has identified new molecule...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
4 September 2025
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| In: |
Nature
Year: 2025, Volume: 645, Issue: 8079, Pages: 254-261 |
| ISSN: | 1476-4687 |
| DOI: | 10.1038/s41586-025-09263-w |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41586-025-09263-w Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41586-025-09263-w 
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| Author Notes: | Annalaura Mastrangelo, Iñaki Robles-Vera, Diego Mañanes, Miguel Galán, Marcos Femenía-Muiña, Ana Redondo-Urzainqui, Rafael Barrero-Rodríguez, Eleftheria Papaioannou, Joaquín Amores-Iniesta, Ana Devesa, Manuel Lobo-González, Alba Carreras, Katharina R. Beck, Sophie Ivarsson, Anders Gummesson, Georgios Georgiopoulos, Manuel Rodrigo-Tapias, Sarai Martínez-Cano, Ivan Fernández-López, Vanessa Nuñez, Alessia Ferrarini, Naohiro Inohara, Kimon Stamatelopoulos, Alberto Benguría, Danay Cibrian, Francisco Sánchez-Madrid, Vanesa Alonso-Herranz, Ana Dopazo, Coral Barbas, Jesús Vázquez, Juan Antonio López, Alicia González-Martín, Gabriel Nuñez, Konstantinos Stellos, Göran Bergström, Fredrik Bäckhed, Valentín Fuster, Borja Ibañez & David Sancho |
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| 245 | 1 | 0 | |a Imidazole propionate is a driver and therapeutic target in atherosclerosis |c Annalaura Mastrangelo, Iñaki Robles-Vera, Diego Mañanes, Miguel Galán, Marcos Femenía-Muiña, Ana Redondo-Urzainqui, Rafael Barrero-Rodríguez, Eleftheria Papaioannou, Joaquín Amores-Iniesta, Ana Devesa, Manuel Lobo-González, Alba Carreras, Katharina R. Beck, Sophie Ivarsson, Anders Gummesson, Georgios Georgiopoulos, Manuel Rodrigo-Tapias, Sarai Martínez-Cano, Ivan Fernández-López, Vanessa Nuñez, Alessia Ferrarini, Naohiro Inohara, Kimon Stamatelopoulos, Alberto Benguría, Danay Cibrian, Francisco Sánchez-Madrid, Vanesa Alonso-Herranz, Ana Dopazo, Coral Barbas, Jesús Vázquez, Juan Antonio López, Alicia González-Martín, Gabriel Nuñez, Konstantinos Stellos, Göran Bergström, Fredrik Bäckhed, Valentín Fuster, Borja Ibañez & David Sancho |
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| 520 | |a Atherosclerosis is the main underlying cause of cardiovascular diseases. Its prevention is based on the detection and treatment of traditional cardiovascular risk factors1. However, individuals at risk for early vascular disease often remain unidentified2. Recent research has identified new molecules in the pathophysiology of atherosclerosis3, highlighting the need for alternative disease biomarkers and therapeutic targets to improve early diagnosis and therapy efficacy. Here, we observed that imidazole propionate (ImP), produced by microorganisms, is associated with the extent of atherosclerosis in mice and in two independent human cohorts. Furthermore, ImP administration to atherosclerosis-prone mice fed with chow diet was sufficient to induce atherosclerosis without altering the lipid profile, and was linked to activation of both systemic and local innate and adaptive immunity and inflammation. Specifically, we found that ImP caused atherosclerosis through the imidazoline-1 receptor (I1R, also known as nischarin) in myeloid cells. Blocking this ImP-I1R axis inhibited the development of atherosclerosis induced by ImP or high-cholesterol diet in mice. Identification of the strong association of ImP with active atherosclerosis and the contribution of the ImP-I1R axis to disease progression opens new avenues for improving the early diagnosis and personalized therapy of atherosclerosis. | ||
| 650 | 4 | |a Atherosclerosis | |
| 650 | 4 | |a Translational research | |
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