Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high-grade brain tumors: results from a European survey
Objective Epilepsy surgery is a standard treatment for drug-resistant epilepsy, resulting in seizure freedom in a significant number of cases. Although frequently performed for low-grade brain tumors, it is rarely considered for high-grade tumors, despite the impact of chronic epilepsy on quality of...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
June 2025
|
| In: |
Epilepsia
Year: 2025, Volume: 66, Issue: 6, Pages: 1865-1875 |
| ISSN: | 1528-1167 |
| DOI: | 10.1111/epi.18323 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/epi.18323 Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.18323 
|
| Author Notes: | Robert Lersch, Till Hartlieb, Tom Pieper, Manfred Kudernatsch, Wiebke Hofer, Carmen Barba, Renzo Guerrini, Flavio Giordano, Marianna Pommella, Susanne Schubert-Bast, Steffen Syrbe, Ricardo Rego, Jorge Pinheiro, Martha Feucht, Alexander Beck, Roland Coras, Ingmar Blumcke, Michael Alber, Moritz Tacke, Jan Rémi, Christian Vollmar, Mathias Kunz, Jay Shetty, Ailsa McLellan, Drahoslav Sokol, Jothy Kandasamy, Kerstin Alexandra Klotz, Victoria San Antonio-Arce, Andreas Schulze-Bonhage, Joshua Pepper, William B. Lo, Alexis Arzimanoglou, Stefano Francione, Christian J. Braun, Ingo Borggraefe |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1935953893 | ||
| 003 | DE-627 | ||
| 005 | 20260120113252.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250915s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/epi.18323 |2 doi | |
| 035 | |a (DE-627)1935953893 | ||
| 035 | |a (DE-599)KXP1935953893 | ||
| 035 | |a (OCoLC)1559705333 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Lersch, Robert |e VerfasserIn |0 (DE-588)1376469715 |0 (DE-627)1935954938 |4 aut | |
| 245 | 1 | 0 | |a Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high-grade brain tumors |b results from a European survey |c Robert Lersch, Till Hartlieb, Tom Pieper, Manfred Kudernatsch, Wiebke Hofer, Carmen Barba, Renzo Guerrini, Flavio Giordano, Marianna Pommella, Susanne Schubert-Bast, Steffen Syrbe, Ricardo Rego, Jorge Pinheiro, Martha Feucht, Alexander Beck, Roland Coras, Ingmar Blumcke, Michael Alber, Moritz Tacke, Jan Rémi, Christian Vollmar, Mathias Kunz, Jay Shetty, Ailsa McLellan, Drahoslav Sokol, Jothy Kandasamy, Kerstin Alexandra Klotz, Victoria San Antonio-Arce, Andreas Schulze-Bonhage, Joshua Pepper, William B. Lo, Alexis Arzimanoglou, Stefano Francione, Christian J. Braun, Ingo Borggraefe |
| 264 | 1 | |c June 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.09.2025 | ||
| 500 | |a Veröffentlicht: 01 March 2025 | ||
| 520 | |a Objective Epilepsy surgery is a standard treatment for drug-resistant epilepsy, resulting in seizure freedom in a significant number of cases. Although frequently performed for low-grade brain tumors, it is rarely considered for high-grade tumors, despite the impact of chronic epilepsy on quality of life and cognition. Methods This retrospective multicenter study across 43 European centers evaluated epilepsy surgery outcomes in children with high-grade brain tumors (World Health Organization grades III and IV). Two cohorts of patients younger than 25 years were studied: (1) those undergoing epilepsy surgery after tumor resection (n = 14) and (2) those initially suspected of low-grade lesions but diagnosed with high-grade brain tumors postsurgery (n = 11). Results Eighty percent of patients achieved seizure freedom 1 year after last epilepsy surgery: 71% in Cohort 1 and 91% in Cohort 2. Eighty-four percent were free of disabling seizures (Engel IA-D) after a median follow-up period of 4.3 years (range = 1-15.9 years). No surgery-related deaths occurred. Thirty-two percent of children experienced persistent morbidity, including motor dysfunction, visual impairment, persistent seizures, cognitive deficits, and hydrocephalus. Significance Epilepsy surgery is effective for medically refractory epilepsy in children with high-grade central nervous system tumors and should be considered early, as seizure freedom is achieved in the majority of patients. Despite involving numerous epilepsy centers, only 25 patients were recruited, indicating that this method is rarely considered for high-grade brain tumor patients with medically refractory epilepsy. | ||
| 650 | 4 | |a children | |
| 650 | 4 | |a drug-resistant epilepsy | |
| 650 | 4 | |a epilepsy surgery | |
| 650 | 4 | |a high-grade brain tumors | |
| 650 | 4 | |a seizure freedom | |
| 700 | 1 | |a Hartlieb, Till |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pieper, Tom |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kudernatsch, Manfred |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hofer, Wiebke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Barba, Carmen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Guerrini, Renzo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Giordano, Flavio |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pommella, Marianna |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schubert-Bast, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Syrbe, Steffen |d 1976- |e VerfasserIn |0 (DE-588)133581926 |0 (DE-627)691603138 |0 (DE-576)272999482 |4 aut | |
| 700 | 1 | |a Rego, Ricardo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pinheiro, Jorge |e VerfasserIn |4 aut | |
| 700 | 1 | |a Feucht, Martha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Beck, Alexander |e VerfasserIn |4 aut | |
| 700 | 1 | |a Coras, Roland |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blumcke, Ingmar |e VerfasserIn |4 aut | |
| 700 | 1 | |a Alber, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tacke, Moritz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rémi, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vollmar, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kunz, Mathias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Shetty, Jay |e VerfasserIn |4 aut | |
| 700 | 1 | |a McLellan, Ailsa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sokol, Drahoslav |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kandasamy, Jothy |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Klotz, Kerstin A. |e VerfasserIn |0 (DE-588)1221229737 |0 (DE-627)1738488802 |4 aut | |
| 700 | 1 | |8 2\p |a San Antonio-Arce, Victoria |e VerfasserIn |0 (DE-588)1199147354 |0 (DE-627)1681522322 |4 aut | |
| 700 | 1 | |8 3\p |a Schulze-Bonhage, Andreas |d 1960- |e VerfasserIn |0 (DE-588)1111135428 |0 (DE-627)86552999X |0 (DE-576)475987926 |4 aut | |
| 700 | 1 | |a Pepper, Joshua |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lo, William B. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arzimanoglou, Alexis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Francione, Stefano |e VerfasserIn |4 aut | |
| 700 | 1 | |a Braun, Christian J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Borggräfe, Ingo |d 1972- |e VerfasserIn |0 (DE-588)130104663 |0 (DE-627)490861520 |0 (DE-576)297999443 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Epilepsia |d Oxford [u.a.] : Wiley-Blackwell, 1909 |g 66(2025), 6 vom: Juni, Seite 1865-1875 |h Online-Ressource |w (DE-627)31311711X |w (DE-600)2002194-X |w (DE-576)09088177X |x 1528-1167 |7 nnas |a Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high-grade brain tumors results from a European survey |
| 773 | 1 | 8 | |g volume:66 |g year:2025 |g number:6 |g month:06 |g pages:1865-1875 |g extent:11 |a Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high-grade brain tumors results from a European survey |
| 856 | 4 | 0 | |u https://doi.org/10.1111/epi.18323 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |7 0 |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1111/epi.18323 |x Verlag |z kostenfrei |3 Volltext |7 0 |
| 883 | |8 1\p |a cgwrk |d 20251001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 2\p |a cgwrk |d 20251001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 883 | |8 3\p |a cgwrk |d 20251001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250915 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 133581926 |a Syrbe, Steffen |m 133581926:Syrbe, Steffen |d 910000 |d 910500 |d 50000 |e 910000PS133581926 |e 910500PS133581926 |e 50000PS133581926 |k 0/910000/ |k 1/910000/910500/ |k 0/50000/ |p 11 | ||
| 999 | |a KXP-PPN1935953893 |e 4772267034 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Robert Lersch, Till Hartlieb, Tom Pieper, Manfred Kudernatsch, Wiebke Hofer, Carmen Barba, Renzo Guerrini, Flavio Giordano, Marianna Pommella, Susanne Schubert-Bast, Steffen Syrbe, Ricardo Rego, Jorge Pinheiro, Martha Feucht, Alexander Beck, Roland Coras, Ingmar Blumcke, Michael Alber, Moritz Tacke, Jan Rémi, Christian Vollmar, Mathias Kunz, Jay Shetty, Ailsa McLellan, Drahoslav Sokol, Jothy Kandasamy, Kerstin Alexandra Klotz, Victoria San Antonio-Arce, Andreas Schulze-Bonhage, Joshua Pepper, William B. Lo, Alexis Arzimanoglou, Stefano Francione, Christian J. Braun, Ingo Borggraefe"]},"person":[{"display":"Lersch, Robert","role":"aut","given":"Robert","roleDisplay":"VerfasserIn","family":"Lersch"},{"family":"Hartlieb","roleDisplay":"VerfasserIn","display":"Hartlieb, Till","role":"aut","given":"Till"},{"display":"Pieper, Tom","role":"aut","given":"Tom","family":"Pieper","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Kudernatsch","display":"Kudernatsch, Manfred","role":"aut","given":"Manfred"},{"display":"Hofer, Wiebke","role":"aut","given":"Wiebke","family":"Hofer","roleDisplay":"VerfasserIn"},{"given":"Carmen","display":"Barba, Carmen","role":"aut","family":"Barba","roleDisplay":"VerfasserIn"},{"family":"Guerrini","roleDisplay":"VerfasserIn","role":"aut","display":"Guerrini, Renzo","given":"Renzo"},{"roleDisplay":"VerfasserIn","family":"Giordano","given":"Flavio","display":"Giordano, Flavio","role":"aut"},{"display":"Pommella, Marianna","role":"aut","given":"Marianna","family":"Pommella","roleDisplay":"VerfasserIn"},{"family":"Schubert-Bast","roleDisplay":"VerfasserIn","role":"aut","display":"Schubert-Bast, Susanne","given":"Susanne"},{"given":"Steffen","display":"Syrbe, Steffen","role":"aut","family":"Syrbe","roleDisplay":"VerfasserIn"},{"family":"Rego","roleDisplay":"VerfasserIn","display":"Rego, Ricardo","role":"aut","given":"Ricardo"},{"roleDisplay":"VerfasserIn","family":"Pinheiro","given":"Jorge","display":"Pinheiro, Jorge","role":"aut"},{"family":"Feucht","roleDisplay":"VerfasserIn","role":"aut","display":"Feucht, Martha","given":"Martha"},{"family":"Beck","roleDisplay":"VerfasserIn","role":"aut","display":"Beck, Alexander","given":"Alexander"},{"role":"aut","display":"Coras, Roland","given":"Roland","roleDisplay":"VerfasserIn","family":"Coras"},{"family":"Blumcke","roleDisplay":"VerfasserIn","role":"aut","display":"Blumcke, Ingmar","given":"Ingmar"},{"roleDisplay":"VerfasserIn","family":"Alber","given":"Michael","display":"Alber, Michael","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Tacke","given":"Moritz","role":"aut","display":"Tacke, Moritz"},{"role":"aut","display":"Rémi, Jan","given":"Jan","roleDisplay":"VerfasserIn","family":"Rémi"},{"roleDisplay":"VerfasserIn","family":"Vollmar","given":"Christian","display":"Vollmar, Christian","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Kunz","given":"Mathias","role":"aut","display":"Kunz, Mathias"},{"role":"aut","display":"Shetty, Jay","given":"Jay","family":"Shetty","roleDisplay":"VerfasserIn"},{"family":"McLellan","roleDisplay":"VerfasserIn","given":"Ailsa","display":"McLellan, Ailsa","role":"aut"},{"family":"Sokol","roleDisplay":"VerfasserIn","display":"Sokol, Drahoslav","role":"aut","given":"Drahoslav"},{"role":"aut","display":"Kandasamy, Jothy","given":"Jothy","roleDisplay":"VerfasserIn","family":"Kandasamy"},{"given":"Kerstin A.","display":"Klotz, Kerstin A.","role":"aut","roleDisplay":"VerfasserIn","family":"Klotz"},{"role":"aut","display":"San Antonio-Arce, Victoria","given":"Victoria","family":"San Antonio-Arce","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Schulze-Bonhage","role":"aut","display":"Schulze-Bonhage, Andreas","given":"Andreas"},{"given":"Joshua","display":"Pepper, Joshua","role":"aut","family":"Pepper","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Lo","display":"Lo, William B.","role":"aut","given":"William B."},{"roleDisplay":"VerfasserIn","family":"Arzimanoglou","given":"Alexis","role":"aut","display":"Arzimanoglou, Alexis"},{"given":"Stefano","display":"Francione, Stefano","role":"aut","family":"Francione","roleDisplay":"VerfasserIn"},{"given":"Christian J.","display":"Braun, Christian J.","role":"aut","family":"Braun","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Borggräfe","role":"aut","display":"Borggräfe, Ingo","given":"Ingo"}],"physDesc":[{"noteIll":"Illustrationen","extent":"11 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"part":{"text":"66(2025), 6 vom: Juni, Seite 1865-1875","volume":"66","issue":"6","year":"2025","extent":"11","pages":"1865-1875"},"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"1909-","publisherPlace":"Oxford [u.a.] ; Malden, Mass. ; Oxford [u.a.]","dateIssuedKey":"1909","publisher":"Wiley-Blackwell ; Blackwell Science ; Blackwell"}],"language":["eng"],"disp":"Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high-grade brain tumors results from a European surveyEpilepsia","note":["Gesehen am 08.09.20"],"id":{"issn":["1528-1167"],"eki":["31311711X"],"doi":["10.1111/(ISSN)1528-1167"],"zdb":["2002194-X"]},"title":[{"title":"Epilepsia","title_sort":"Epilepsia","subtitle":"the journal of the International League Against Epilepsy"}],"pubHistory":["1.1909 -"],"recId":"31311711X"}],"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2025","dateIssuedDisp":"June 2025"}],"id":{"eki":["1935953893"],"doi":["10.1111/epi.18323"]},"title":[{"title_sort":"Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high-grade brain tumors","title":"Seizure outcomes following epilepsy surgery in pediatric and young adult patients with high-grade brain tumors","subtitle":"results from a European survey"}],"recId":"1935953893","note":["Gesehen am 15.09.2025","Veröffentlicht: 01 March 2025"]} | ||
| SRT | |a LERSCHROBESEIZUREOUT2025 | ||