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Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion

Melanoma is an aggressive skin cancer and highly lethal at advanced stages due to its high tumorigenicity and metastatic capacity. Changing the phenotype of cancer cells from one lineage to another, a process called transdifferentiation, leads to tumor cell reversion, which goes along with a drastic...

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Main Authors: Wang, Yiman (Author) , Liu, Ke (Author) , Zhang, Yuxin (Author) , Novak, Daniel (Author) , Federico, Aniello (Author) , Xu, Cai (Author) , Horschitz, Sandra (Author) , Vierthaler, Marlene (Author) , Sun, Qian (Author) , Wang, Nina (Author) , Poelchen, Juliane (Author) , Steinfass, Tamara (Author) , Hüser, Laura (Author) , Mall, Moritz (Author) , Umansky, Viktor (Author) , Utikal, Jochen (Author)
Format: Article (Journal)
Language:English
Published: 25 July 2025
In: Cell death & disease
Year: 2025, Volume: 16, Pages: 1-12
ISSN:2041-4889
DOI:10.1038/s41419-025-07863-y
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41419-025-07863-y
Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41419-025-07863-y
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Author Notes:Yiman Wang, Ke Liu, Yuxin Zhang, Daniel Novak, Aniello Federico, Cai Xu, Sandra Horschitz, Marlene Vierthaler, Qian Sun, Nina Wang, Juliane Poelchen, Tamara Steinfass, Laura Hüser, Moritz Mall, Viktor Umansky and Jochen Utikal
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Summary:Melanoma is an aggressive skin cancer and highly lethal at advanced stages due to its high tumorigenicity and metastatic capacity. Changing the phenotype of cancer cells from one lineage to another, a process called transdifferentiation, leads to tumor cell reversion, which goes along with a drastic reduction of their tumorigenicity. Via ectopic overexpression of four neuronal transcription factors, we transdifferentiated melanoma cells into neuron-like cells expressing neuronal markers and showing a neuron-like morphology. Moreover, the tumorigenic and metastatic potential of transdifferentiated cells in vitro and in vivo was significantly reduced. Transdifferentiated cells were also more sensitive to radiotherapy compared with their parental counterparts. We conclude that transdifferentiation of cancer cells into terminally differentiated neuron-like cells might represent a prospective new therapeutic approach for the treatment of melanoma.
Item Description:Gesehen am 22.09.2025
Physical Description:Online Resource
ISSN:2041-4889
DOI:10.1038/s41419-025-07863-y

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