Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion
Melanoma is an aggressive skin cancer and highly lethal at advanced stages due to its high tumorigenicity and metastatic capacity. Changing the phenotype of cancer cells from one lineage to another, a process called transdifferentiation, leads to tumor cell reversion, which goes along with a drastic...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
25 July 2025
|
| In: |
Cell death & disease
Year: 2025, Volume: 16, Pages: 1-12 |
| ISSN: | 2041-4889 |
| DOI: | 10.1038/s41419-025-07863-y |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41419-025-07863-y Verlag, kostenfrei, Volltext: http://www.nature.com/articles/s41419-025-07863-y 
|
| Author Notes: | Yiman Wang, Ke Liu, Yuxin Zhang, Daniel Novak, Aniello Federico, Cai Xu, Sandra Horschitz, Marlene Vierthaler, Qian Sun, Nina Wang, Juliane Poelchen, Tamara Steinfass, Laura Hüser, Moritz Mall, Viktor Umansky and Jochen Utikal |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1936371685 | ||
| 003 | DE-627 | ||
| 005 | 20250922141357.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250922s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41419-025-07863-y |2 doi | |
| 035 | |a (DE-627)1936371685 | ||
| 035 | |a (DE-599)KXP1936371685 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Wang, Yiman |d 1994- |e VerfasserIn |0 (DE-588)1290221146 |0 (DE-627)1845935403 |4 aut | |
| 245 | 1 | 0 | |a Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion |c Yiman Wang, Ke Liu, Yuxin Zhang, Daniel Novak, Aniello Federico, Cai Xu, Sandra Horschitz, Marlene Vierthaler, Qian Sun, Nina Wang, Juliane Poelchen, Tamara Steinfass, Laura Hüser, Moritz Mall, Viktor Umansky and Jochen Utikal |
| 264 | 1 | |c 25 July 2025 | |
| 300 | |b Illustrationen, Diagramme | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 22.09.2025 | ||
| 520 | |a Melanoma is an aggressive skin cancer and highly lethal at advanced stages due to its high tumorigenicity and metastatic capacity. Changing the phenotype of cancer cells from one lineage to another, a process called transdifferentiation, leads to tumor cell reversion, which goes along with a drastic reduction of their tumorigenicity. Via ectopic overexpression of four neuronal transcription factors, we transdifferentiated melanoma cells into neuron-like cells expressing neuronal markers and showing a neuron-like morphology. Moreover, the tumorigenic and metastatic potential of transdifferentiated cells in vitro and in vivo was significantly reduced. Transdifferentiated cells were also more sensitive to radiotherapy compared with their parental counterparts. We conclude that transdifferentiation of cancer cells into terminally differentiated neuron-like cells might represent a prospective new therapeutic approach for the treatment of melanoma. | ||
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Preclinical research | |
| 700 | 1 | |a Liu, Ke |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhang, Yuxin |d 1996- |e VerfasserIn |0 (DE-588)137024360X |0 (DE-627)1929387784 |4 aut | |
| 700 | 1 | |a Novak, Daniel |d 1978- |e VerfasserIn |0 (DE-588)1026462975 |0 (DE-627)726763764 |0 (DE-576)371815533 |4 aut | |
| 700 | 1 | |a Federico, Aniello |d 1990- |e VerfasserIn |0 (DE-588)1197267964 |0 (DE-627)1679058754 |4 aut | |
| 700 | 1 | |a Xu, Cai |e VerfasserIn |4 aut | |
| 700 | 1 | |a Horschitz, Sandra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Vierthaler, Marlene |d 1991- |e VerfasserIn |0 (DE-588)1253024111 |0 (DE-627)1794873279 |4 aut | |
| 700 | 1 | |a Sun, Qian |e VerfasserIn |0 (DE-588)1244231878 |0 (DE-627)1775296148 |4 aut | |
| 700 | 1 | |a Wang, Nina |d 1992- |e VerfasserIn |0 (DE-588)1364773651 |0 (DE-627)1924816105 |4 aut | |
| 700 | 1 | |a Poelchen, Juliane |d 1993- |e VerfasserIn |0 (DE-588)1237827760 |0 (DE-627)1764891562 |4 aut | |
| 700 | 1 | |a Steinfass, Tamara |d 1992- |e VerfasserIn |0 (DE-588)1272471241 |0 (DE-627)182159634X |4 aut | |
| 700 | 1 | |a Hüser, Laura |d 1989- |e VerfasserIn |0 (DE-588)1160493715 |0 (DE-627)1023730499 |0 (DE-576)505948931 |4 aut | |
| 700 | 1 | |a Mall, Moritz |e VerfasserIn |0 (DE-588)1168277477 |0 (DE-627)1031930213 |0 (DE-576)511500866 |4 aut | |
| 700 | 1 | |a Umansky, Viktor |d 1955- |e VerfasserIn |0 (DE-588)102885756X |0 (DE-627)731733207 |0 (DE-576)376300078 |4 aut | |
| 700 | 1 | |a Utikal, Jochen |d 1974- |e VerfasserIn |0 (DE-588)1026463750 |0 (DE-627)726765015 |0 (DE-576)371816580 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cell death & disease |d London [u.a.] : Nature Publishing Group, 2010 |g 16(2025), Artikel-ID 563, Seite 1-12 |h Online-Ressource |w (DE-627)620145250 |w (DE-600)2541626-1 |w (DE-576)319429059 |x 2041-4889 |7 nnas |a Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion |
| 773 | 1 | 8 | |g volume:16 |g year:2025 |g elocationid:563 |g pages:1-12 |g extent:12 |a Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41419-025-07863-y |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u http://www.nature.com/articles/s41419-025-07863-y |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250922 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1168277477 |a Mall, Moritz |m 1168277477:Mall, Moritz |d 140000 |e 140000PM1168277477 |k 0/140000/ |p 16 |y j | ||
| 998 | |g 102885756X |a Umansky, Viktor |m 102885756X:Umansky, Viktor |d 60000 |d 61900 |d 140000 |e 60000PU102885756X |e 61900PU102885756X |e 140000PU102885756X |k 0/60000/ |k 1/60000/61900/ |k 0/140000/ |p 15 | ||
| 998 | |g 1026463750 |a Utikal, Jochen |m 1026463750:Utikal, Jochen |d 60000 |e 60000PU1026463750 |k 0/60000/ |p 13 | ||
| 998 | |g 1364773651 |a Wang, Nina |m 1364773651:Wang, Nina |d 60000 |e 60000PW1364773651 |k 0/60000/ |p 10 | ||
| 998 | |g 1244231878 |a Sun, Qian |m 1244231878:Sun, Qian |d 60000 |e 60000PS1244231878 |k 0/60000/ |p 9 | ||
| 998 | |g 1026462975 |a Novak, Daniel |m 1026462975:Novak, Daniel |d 60000 |d 61900 |e 60000PN1026462975 |e 61900PN1026462975 |k 0/60000/ |k 1/60000/61900/ |p 4 | ||
| 998 | |g 137024360X |a Zhang, Yuxin |m 137024360X:Zhang, Yuxin |d 60000 |e 60000PZ137024360X |k 0/60000/ |p 3 | ||
| 998 | |g 1290221146 |a Wang, Yiman |m 1290221146:Wang, Yiman |d 60000 |e 60000PW1290221146 |k 0/60000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1936371685 |e 4774788929 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"role":"aut","display":"Wang, Yiman","given":"Yiman","family":"Wang","roleDisplay":"VerfasserIn"},{"display":"Liu, Ke","role":"aut","given":"Ke","roleDisplay":"VerfasserIn","family":"Liu"},{"family":"Zhang","roleDisplay":"VerfasserIn","given":"Yuxin","display":"Zhang, Yuxin","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Novak","display":"Novak, Daniel","role":"aut","given":"Daniel"},{"family":"Federico","roleDisplay":"VerfasserIn","given":"Aniello","display":"Federico, Aniello","role":"aut"},{"display":"Xu, Cai","role":"aut","given":"Cai","roleDisplay":"VerfasserIn","family":"Xu"},{"role":"aut","display":"Horschitz, Sandra","given":"Sandra","roleDisplay":"VerfasserIn","family":"Horschitz"},{"given":"Marlene","role":"aut","display":"Vierthaler, Marlene","roleDisplay":"VerfasserIn","family":"Vierthaler"},{"roleDisplay":"VerfasserIn","family":"Sun","given":"Qian","display":"Sun, Qian","role":"aut"},{"role":"aut","display":"Wang, Nina","given":"Nina","family":"Wang","roleDisplay":"VerfasserIn"},{"family":"Poelchen","roleDisplay":"VerfasserIn","display":"Poelchen, Juliane","role":"aut","given":"Juliane"},{"display":"Steinfass, Tamara","role":"aut","given":"Tamara","roleDisplay":"VerfasserIn","family":"Steinfass"},{"given":"Laura","role":"aut","display":"Hüser, Laura","family":"Hüser","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","family":"Mall","display":"Mall, Moritz","role":"aut","given":"Moritz"},{"given":"Viktor","display":"Umansky, Viktor","role":"aut","roleDisplay":"VerfasserIn","family":"Umansky"},{"given":"Jochen","role":"aut","display":"Utikal, Jochen","roleDisplay":"VerfasserIn","family":"Utikal"}],"physDesc":[{"extent":"12 S.","noteIll":"Illustrationen, Diagramme"}],"name":{"displayForm":["Yiman Wang, Ke Liu, Yuxin Zhang, Daniel Novak, Aniello Federico, Cai Xu, Sandra Horschitz, Marlene Vierthaler, Qian Sun, Nina Wang, Juliane Poelchen, Tamara Steinfass, Laura Hüser, Moritz Mall, Viktor Umansky and Jochen Utikal"]},"relHost":[{"titleAlt":[{"title":"Cell death and disease"}],"pubHistory":["1.2010 -"],"recId":"620145250","title":[{"title":"Cell death & disease","title_sort":"Cell death & disease"}],"id":{"issn":["2041-4889"],"zdb":["2541626-1"],"eki":["620145250"]},"disp":"Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversionCell death & disease","note":["Gesehen am 26.02.10"],"part":{"text":"16(2025), Artikel-ID 563, Seite 1-12","volume":"16","year":"2025","extent":"12","pages":"1-12"},"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"origin":[{"publisher":"Nature Publishing Group","publisherPlace":"London [u.a.]","dateIssuedKey":"2010","dateIssuedDisp":"2010-"}],"type":{"media":"Online-Ressource","bibl":"periodical"}}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"25 July 2025","dateIssuedKey":"2025"}],"language":["eng"],"recId":"1936371685","title":[{"title_sort":"Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion","title":"Direct transdifferentiation of tumorigenic melanoma cells induces tumor cell reversion"}],"id":{"doi":["10.1038/s41419-025-07863-y"],"eki":["1936371685"]},"note":["Gesehen am 22.09.2025"]} | ||
| SRT | |a WANGYIMANLDIRECTTRAN2520 | ||