Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology
Clinical decision-making in oncology is complex, requiring the integration of multimodal data and multidomain expertise. We developed and evaluated an autonomous clinical artificial intelligence (AI) agent leveraging GPT-4 with multimodal precision oncology tools to support personalized clinical dec...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
06 June 2025
|
| In: |
Nature cancer
Year: 2025, Jahrgang: 6, Heft: 8, Pages: 1337-1349 |
| ISSN: | 2662-1347 |
| DOI: | 10.1038/s43018-025-00991-6 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s43018-025-00991-6 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s43018-025-00991-6 
|
| Verfasserangaben: | Dyke Ferber, Omar S.M. El Nahhas, Georg Wölflein, Isabella C. Wiest, Jan Clusmann, Marie-Elisabeth Leßmann, Sebastian Foersch, Jacqueline Lammert, Maximilian Tschochohei, Dirk Jäger, Manuel Salto-Tellez, Nikolaus Schultz, Daniel Truhn & Jakob Nikolas Kather |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1936679477 | ||
| 003 | DE-627 | ||
| 005 | 20251023215737.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250924s2025 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s43018-025-00991-6 |2 doi | |
| 035 | |a (DE-627)1936679477 | ||
| 035 | |a (DE-599)KXP1936679477 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ferber, Dyke |e VerfasserIn |0 (DE-588)1171467079 |0 (DE-627)1040545629 |0 (DE-576)513746056 |4 aut | |
| 245 | 1 | 0 | |a Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology |c Dyke Ferber, Omar S.M. El Nahhas, Georg Wölflein, Isabella C. Wiest, Jan Clusmann, Marie-Elisabeth Leßmann, Sebastian Foersch, Jacqueline Lammert, Maximilian Tschochohei, Dirk Jäger, Manuel Salto-Tellez, Nikolaus Schultz, Daniel Truhn & Jakob Nikolas Kather |
| 264 | 1 | |c 06 June 2025 | |
| 300 | |b Illustrationen | ||
| 300 | |a 18 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 06. Juni 2025 | ||
| 500 | |a Gesehen am 24.09.2025 | ||
| 520 | |a Clinical decision-making in oncology is complex, requiring the integration of multimodal data and multidomain expertise. We developed and evaluated an autonomous clinical artificial intelligence (AI) agent leveraging GPT-4 with multimodal precision oncology tools to support personalized clinical decision-making. The system incorporates vision transformers for detecting microsatellite instability and KRAS and BRAF mutations from histopathology slides, MedSAM for radiological image segmentation and web-based search tools such as OncoKB, PubMed and Google. Evaluated on 20 realistic multimodal patient cases, the AI agent autonomously used appropriate tools with 87.5% accuracy, reached correct clinical conclusions in 91.0% of cases and accurately cited relevant oncology guidelines 75.5% of the time. Compared to GPT-4 alone, the integrated AI agent drastically improved decision-making accuracy from 30.3% to 87.2%. These findings demonstrate that integrating language models with precision oncology and search tools substantially enhances clinical accuracy, establishing a robust foundation for deploying AI-driven personalized oncology support systems. | ||
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Cancer therapy | |
| 650 | 4 | |a Data integration | |
| 650 | 4 | |a Information technology | |
| 700 | 1 | |a El Nahhas, Omar S. M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wölflein, Georg |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wiest, Isabella |d 1992- |e VerfasserIn |0 (DE-588)1198882956 |0 (DE-627)168103638X |4 aut | |
| 700 | 1 | |a Clusmann, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Leßmann, Marie-Elisabeth |e VerfasserIn |4 aut | |
| 700 | 1 | |a Foersch, Sebastian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lammert, Jacqueline |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tschochohei, Maximilian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jäger, Dirk |d 1964- |e VerfasserIn |0 (DE-588)1032507535 |0 (DE-627)738505323 |0 (DE-576)380074125 |4 aut | |
| 700 | 1 | |a Salto-Tellez, Manuel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schultz, Nikolaus |e VerfasserIn |4 aut | |
| 700 | 1 | |8 1\p |a Truhn, Daniel |e VerfasserIn |0 (DE-588)1047348306 |0 (DE-627)778145913 |0 (DE-576)400927314 |4 aut | |
| 700 | 1 | |a Kather, Jakob Nikolas |d 1989- |e VerfasserIn |0 (DE-588)1064064914 |0 (DE-627)812897587 |0 (DE-576)423589091 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature cancer |d London : Nature Research, 2020 |g 6(2025), 8, Seite 1337-1349 |h Online-Ressource |w (DE-627)1687330697 |w (DE-600)3005299-3 |x 2662-1347 |7 nnas |a Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology |
| 773 | 1 | 8 | |g volume:6 |g year:2025 |g number:8 |g pages:1337-1349 |g extent:18 |a Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s43018-025-00991-6 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s43018-025-00991-6 |x Verlag |z kostenfrei |3 Volltext |
| 883 | |8 1\p |a cgwrk |d 20251001 |q DE-101 |u https://d-nb.info/provenance/plan#cgwrk | ||
| 951 | |a AR | ||
| 992 | |a 20250924 | ||
| 993 | |a Article | ||
| 994 | |a 2025 | ||
| 998 | |g 1064064914 |a Kather, Jakob Nikolas |m 1064064914:Kather, Jakob Nikolas |d 910000 |d 910100 |e 910000PK1064064914 |e 910100PK1064064914 |k 0/910000/ |k 1/910000/910100/ |p 14 |y j | ||
| 998 | |g 1032507535 |a Jäger, Dirk |m 1032507535:Jäger, Dirk |d 910000 |e 910000PJ1032507535 |k 0/910000/ |p 10 | ||
| 998 | |g 1198882956 |a Wiest, Isabella |m 1198882956:Wiest, Isabella |d 60000 |d 61100 |e 60000PW1198882956 |e 61100PW1198882956 |k 0/60000/ |k 1/60000/61100/ |p 4 | ||
| 998 | |g 1171467079 |a Ferber, Dyke |m 1171467079:Ferber, Dyke |d 910000 |d 910100 |e 910000PF1171467079 |e 910100PF1171467079 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1936679477 |e 4775623974 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedDisp":"06 June 2025","dateIssuedKey":"2025"}],"recId":"1936679477","language":["eng"],"note":["Online veröffentlicht: 06. Juni 2025","Gesehen am 24.09.2025"],"name":{"displayForm":["Dyke Ferber, Omar S.M. El Nahhas, Georg Wölflein, Isabella C. Wiest, Jan Clusmann, Marie-Elisabeth Leßmann, Sebastian Foersch, Jacqueline Lammert, Maximilian Tschochohei, Dirk Jäger, Manuel Salto-Tellez, Nikolaus Schultz, Daniel Truhn & Jakob Nikolas Kather"]},"physDesc":[{"noteIll":"Illustrationen","extent":"18 S."}],"relHost":[{"disp":"Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncologyNature cancer","origin":[{"dateIssuedDisp":"2020-","publisher":"Nature Research","dateIssuedKey":"2020","publisherPlace":"London"}],"note":["Gesehen am 14.01.20"],"part":{"extent":"18","year":"2025","volume":"6","text":"6(2025), 8, Seite 1337-1349","pages":"1337-1349","issue":"8"},"language":["eng"],"recId":"1687330697","title":[{"title":"Nature cancer","title_sort":"Nature cancer"}],"physDesc":[{"extent":"Online-Ressource"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"id":{"zdb":["3005299-3"],"eki":["1687330697"],"issn":["2662-1347"]},"pubHistory":["Volume 1, Issue 1, (January 2020)-"]}],"title":[{"title":"Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology","title_sort":"Development and validation of an autonomous artificial intelligence agent for clinical decision-making in oncology"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"id":{"eki":["1936679477"],"doi":["10.1038/s43018-025-00991-6"]},"person":[{"display":"Ferber, Dyke","family":"Ferber","given":"Dyke","role":"aut"},{"family":"El Nahhas","display":"El Nahhas, Omar S. M.","role":"aut","given":"Omar S. M."},{"family":"Wölflein","display":"Wölflein, Georg","role":"aut","given":"Georg"},{"family":"Wiest","display":"Wiest, Isabella","role":"aut","given":"Isabella"},{"given":"Jan","role":"aut","display":"Clusmann, Jan","family":"Clusmann"},{"given":"Marie-Elisabeth","role":"aut","display":"Leßmann, Marie-Elisabeth","family":"Leßmann"},{"given":"Sebastian","role":"aut","display":"Foersch, Sebastian","family":"Foersch"},{"given":"Jacqueline","role":"aut","display":"Lammert, Jacqueline","family":"Lammert"},{"role":"aut","given":"Maximilian","family":"Tschochohei","display":"Tschochohei, Maximilian"},{"given":"Dirk","role":"aut","display":"Jäger, Dirk","family":"Jäger"},{"given":"Manuel","role":"aut","display":"Salto-Tellez, Manuel","family":"Salto-Tellez"},{"display":"Schultz, Nikolaus","family":"Schultz","given":"Nikolaus","role":"aut"},{"given":"Daniel","role":"aut","display":"Truhn, Daniel","family":"Truhn"},{"display":"Kather, Jakob Nikolas","family":"Kather","given":"Jakob Nikolas","role":"aut"}]} | ||
| SRT | |a FERBERDYKEDEVELOPMEN0620 | ||