Risk of major vascular events in patients without traditional risk factors after transient ischemic attack or minor ischemic stroke: an international prospective cohort
Introduction: To investigate the clinical characteristics in patients without traditional risk factors (TRFs) after transient ischemic attack or minor ischemic stroke, who were recruited in the TIAregistry.org. - Patients and methods: A total of 3847 patients were analyzed. TRFs included hypertensio...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 2025
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| In: |
European stroke journal
Year: 2025, Jahrgang: 10, Heft: 2, Pages: 531-540 |
| ISSN: | 2396-9881 |
| DOI: | 10.1177/23969873241300071 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1177/23969873241300071
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| Verfasserangaben: | Shinichiro Uchiyama, Takao Hoshino, Kazuo Minematsu, Marie-Laure Meledje, Hugo Charles, Gregory W Albers, Louis R Caplan, Geoffrey A Donnan, José M Ferro, Michael G Hennerici, Carlos Molina, Peter M Rothwell, Lawrence KS Wong, and Pierre Amarenco, on behalf of the TIAregistry.org Investigators |
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| 100 | 1 | |a Uchiyama, Shinichiro |e VerfasserIn |0 (DE-588)1237230608 |0 (DE-627)1763154130 |4 aut | |
| 245 | 1 | 0 | |a Risk of major vascular events in patients without traditional risk factors after transient ischemic attack or minor ischemic stroke |b an international prospective cohort |c Shinichiro Uchiyama, Takao Hoshino, Kazuo Minematsu, Marie-Laure Meledje, Hugo Charles, Gregory W Albers, Louis R Caplan, Geoffrey A Donnan, José M Ferro, Michael G Hennerici, Carlos Molina, Peter M Rothwell, Lawrence KS Wong, and Pierre Amarenco, on behalf of the TIAregistry.org Investigators |
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| 500 | |a Online veröffentlicht: 21. November 2024 | ||
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| 520 | |a Introduction: To investigate the clinical characteristics in patients without traditional risk factors (TRFs) after transient ischemic attack or minor ischemic stroke, who were recruited in the TIAregistry.org. - Patients and methods: A total of 3847 patients were analyzed. TRFs included hypertension, diabetes, hypercholesterolemia, current smoking, and atrial fibrillation. Background characteristics and outcomes at 1 and 5 years in patients without TRFs were compared to those in patients with TRFs. The primary outcome was major cardiovascular event (MACE), which was non-fatal stroke, non-fatal acute coronary syndrome, or vascular death. To evaluate the causes, we applied the ASCOD (atherosclerosis, small vessel disease, cardiac pathology, other causes or dissection) grading system. - Results: One-year risk of MACE (5.3% vs 6.3%, hazard ratio (HR) 0.84, 95% confidence interval (CI) 0.53-1.31) was comparable between patients without TRFs (n = 402) and those with TRFs (n = 3445). Five-year risk of MACE was significantly lower in patients without TRFs than in those with TRFs (7.9% vs 13.9%, HR 0.57, 95% CI 0.39-0.82). In patients without TRFs, causal atherosclerosis was a potent risk factor (HR 5.67, 95% CI 2.68-12.02) and ipsilateral extra- or intra-cranial arterial stenosis was only significant predictor of MACE (interaction p = 0.0046) at 5 years. - Conclusion and discussion: The 5-year risk of MACE was lower in patients without TRFs than those with TRFs, although a certain level of risk persisted in the absence of TRFs. The most significant predictor of MACE in patients without TRFs was arterial stenosis. | ||
| 700 | 1 | |a Hoshino, Takao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Minematsu, Kazuo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Meledje, Marie-Laure |e VerfasserIn |4 aut | |
| 700 | 1 | |a Charles, Hugo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Albers, Gregory W |e VerfasserIn |4 aut | |
| 700 | 1 | |a Caplan, Louis R |e VerfasserIn |4 aut | |
| 700 | 1 | |a Donnan, Geoffrey A |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ferro, José M |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hennerici, Michael G. |d 1948- |e VerfasserIn |0 (DE-588)11587545X |0 (DE-627)077527704 |0 (DE-576)290126444 |4 aut | |
| 700 | 1 | |a Molina, Carlos |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rothwell, Peter M |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wong, Lawrence KS |e VerfasserIn |4 aut | |
| 700 | 1 | |a Amarenco, Pierre |e VerfasserIn |4 aut | |
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