Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab
Aim: To evaluate changes in health-related quality of life (HRQoL) in a Phase II trial (NCT02155647) of treatment-naive patients with metastatic Merkel cell carcinoma treated with avelumab (15-month follow-up). Materials & methods: Mixed-effect Models for Repeated Measures were applied to HRQoL...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2020
|
| In: |
Future oncology
Year: 2020, Jahrgang: 16, Heft: 27, Pages: 2089-2099 |
| ISSN: | 1744-8301 |
| DOI: | 10.2217/fon-2020-0426 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.2217/fon-2020-0426 Verlag, kostenfrei, Volltext: https://www.tandfonline.com/doi/full/10.2217/fon-2020-0426 
|
| Verfasserangaben: | Murtuza Bharmal, Sandra Nolte, Céleste Lebbé, Laurent Mortier, Andrew S Brohl, Nicola Fazio, Jean-Jacquez Grob, Sara Pusceddu, Glenn J Hanna, Jessica C Hassel, Felix Kiecker, Barbara Ellers-Lenz, Marcis Bajars, Gülseren Güzel, Paul Nghiem, Matthias Hunger, Michael Schlichting, Mickaël Henry-Szatkowsk &, Sandra P. D’Angelo |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1936996928 | ||
| 003 | DE-627 | ||
| 005 | 20250925151007.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 250925s2020 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2217/fon-2020-0426 |2 doi | |
| 035 | |a (DE-627)1936996928 | ||
| 035 | |a (DE-599)KXP1936996928 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Bharmal, Murtuza |e VerfasserIn |0 (DE-588)1377424138 |0 (DE-627)1936996715 |4 aut | |
| 245 | 1 | 0 | |a Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab |c Murtuza Bharmal, Sandra Nolte, Céleste Lebbé, Laurent Mortier, Andrew S Brohl, Nicola Fazio, Jean-Jacquez Grob, Sara Pusceddu, Glenn J Hanna, Jessica C Hassel, Felix Kiecker, Barbara Ellers-Lenz, Marcis Bajars, Gülseren Güzel, Paul Nghiem, Matthias Hunger, Michael Schlichting, Mickaël Henry-Szatkowsk &, Sandra P. D’Angelo |
| 264 | 1 | |c 2020 | |
| 300 | |b Illustrationen | ||
| 300 | |a 11 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.09.2025 | ||
| 520 | |a Aim: To evaluate changes in health-related quality of life (HRQoL) in a Phase II trial (NCT02155647) of treatment-naive patients with metastatic Merkel cell carcinoma treated with avelumab (15-month follow-up). Materials & methods: Mixed-effect Models for Repeated Measures were applied to HRQoL data (FACT-M; EQ-5D-5L) to assess changes over time. Clinically derived progression-free survival was compared with HRQoL deterioration-free survival. Results: Overall, we saw relative stability in HRQoL among 116 included patients, with nonprogression associated with statistically and clinically meaningful better HRQoL compared with progressive disease. Deterioration-free survival rates (49-72% at 6 months, 40-58% at 12 months) were consistently higher/better compared with progression-free survival rates (41/31% at 6/12 months). Conclusion: These findings show unique longitudinal HRQoL data for treatment-naive metastatic Merkel cell carcinoma patients treated with avelumab. Clinical trial registration: NCT02155647 (ClinicalTrials.gov). Infographic: A PDF version of this infographic is available as supplemental material. | ||
| 650 | 4 | |a FACT-M questionnaire | |
| 650 | 4 | |a health-related quality of life | |
| 650 | 4 | |a Merkel cell carcinoma | |
| 650 | 4 | |a patient reported outcome | |
| 650 | 4 | |a self report | |
| 700 | 1 | |a Nolte, Sandra |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lebbé, Céleste |e VerfasserIn |4 aut | |
| 700 | 1 | |a Mortier, Laurent |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brohl, Andrew S |e VerfasserIn |4 aut | |
| 700 | 1 | |a Fazio, Nicola |e VerfasserIn |4 aut | |
| 700 | 1 | |a Grob, Jean-Jacquez |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pusceddu, Sara |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hanna, Glenn J |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hassel, Jessica C. |d 1975- |e VerfasserIn |0 (DE-588)129790702 |0 (DE-627)480399069 |0 (DE-576)29783715X |4 aut | |
| 700 | 1 | |a Kiecker, Felix |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ellers-Lenz, Barbara |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bajars, Marcis |e VerfasserIn |4 aut | |
| 700 | 1 | |a Güzel, Gülseren |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nghiem, Paul |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hunger, Matthias |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schlichting, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Henry-Szatkowski, Mickaël |e VerfasserIn |4 aut | |
| 700 | 1 | |a D’Angelo, Sandra P. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Future oncology |d London : Taylor & Francis, 2005 |g 16(2020), 27, Seite 2089-2099 |h Online-Ressource |w (DE-627)484405055 |w (DE-600)2184533-5 |w (DE-576)398100217 |x 1744-8301 |7 nnas |a Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab |
| 773 | 1 | 8 | |g volume:16 |g year:2020 |g number:27 |g pages:2089-2099 |g extent:11 |a Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab |
| 856 | 4 | 0 | |u https://doi.org/10.2217/fon-2020-0426 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.tandfonline.com/doi/full/10.2217/fon-2020-0426 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20250925 | ||
| 993 | |a Article | ||
| 994 | |a 2020 | ||
| 998 | |g 129790702 |a Hassel, Jessica C. |m 129790702:Hassel, Jessica C. |d 910000 |d 911300 |d 50000 |e 910000PH129790702 |e 911300PH129790702 |e 50000PH129790702 |k 0/910000/ |k 1/910000/911300/ |k 0/50000/ |p 10 | ||
| 999 | |a KXP-PPN1936996928 |e 4776012839 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Murtuza Bharmal, Sandra Nolte, Céleste Lebbé, Laurent Mortier, Andrew S Brohl, Nicola Fazio, Jean-Jacquez Grob, Sara Pusceddu, Glenn J Hanna, Jessica C Hassel, Felix Kiecker, Barbara Ellers-Lenz, Marcis Bajars, Gülseren Güzel, Paul Nghiem, Matthias Hunger, Michael Schlichting, Mickaël Henry-Szatkowsk &, Sandra P. D’Angelo"]},"person":[{"family":"Bharmal","display":"Bharmal, Murtuza","role":"aut","given":"Murtuza"},{"family":"Nolte","role":"aut","given":"Sandra","display":"Nolte, Sandra"},{"role":"aut","given":"Céleste","display":"Lebbé, Céleste","family":"Lebbé"},{"family":"Mortier","given":"Laurent","role":"aut","display":"Mortier, Laurent"},{"role":"aut","given":"Andrew S","display":"Brohl, Andrew S","family":"Brohl"},{"family":"Fazio","given":"Nicola","role":"aut","display":"Fazio, Nicola"},{"family":"Grob","role":"aut","given":"Jean-Jacquez","display":"Grob, Jean-Jacquez"},{"family":"Pusceddu","display":"Pusceddu, Sara","role":"aut","given":"Sara"},{"display":"Hanna, Glenn J","given":"Glenn J","role":"aut","family":"Hanna"},{"display":"Hassel, Jessica C.","role":"aut","given":"Jessica C.","family":"Hassel"},{"family":"Kiecker","display":"Kiecker, Felix","role":"aut","given":"Felix"},{"family":"Ellers-Lenz","display":"Ellers-Lenz, Barbara","role":"aut","given":"Barbara"},{"display":"Bajars, Marcis","role":"aut","given":"Marcis","family":"Bajars"},{"role":"aut","given":"Gülseren","display":"Güzel, Gülseren","family":"Güzel"},{"family":"Nghiem","role":"aut","given":"Paul","display":"Nghiem, Paul"},{"family":"Hunger","given":"Matthias","role":"aut","display":"Hunger, Matthias"},{"display":"Schlichting, Michael","given":"Michael","role":"aut","family":"Schlichting"},{"family":"Henry-Szatkowski","role":"aut","given":"Mickaël","display":"Henry-Szatkowski, Mickaël"},{"family":"D’Angelo","role":"aut","given":"Sandra P.","display":"D’Angelo, Sandra P."}],"recId":"1936996928","origin":[{"dateIssuedDisp":"2020","dateIssuedKey":"2020"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1936996928"],"doi":["10.2217/fon-2020-0426"]},"physDesc":[{"extent":"11 S.","noteIll":"Illustrationen"}],"relHost":[{"pubHistory":["1.2005 -"],"part":{"year":"2020","text":"16(2020), 27, Seite 2089-2099","volume":"16","issue":"27","extent":"11","pages":"2089-2099"},"language":["eng"],"title":[{"title":"Future oncology","title_sort":"Future oncology"}],"recId":"484405055","origin":[{"publisherPlace":"London ; London","dateIssuedKey":"2005","dateIssuedDisp":"2005-","publisher":"Taylor & Francis ; Future Medicine Ltd"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 28.05.2024"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1744-8301"],"zdb":["2184533-5"],"eki":["484405055"]},"disp":"Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumabFuture oncology"}],"note":["Gesehen am 25.09.2025"],"title":[{"title":"Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab","title_sort":"Health-related quality of life trajectory of treatment-naive patients with Merkel cell carcinoma receiving avelumab"}],"language":["eng"]} | ||
| SRT | |a BHARMALMURHEALTHRELA2020 | ||