Dissemination of tumor cells in patients undergoing surgery for colorectal cancer
The majority of patients with colorectal cancer present at a stage when the primary cancer can be resected with curative intent. However, despite the high resectability rate, about 30-50% of these patients subsequently develop metastatic disease. In these patients, neoplastic cells were disseminated...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
February 01 1998
|
| In: |
Clinical cancer research
Year: 1998, Jahrgang: 4, Heft: 2, Pages: 343-348 |
| ISSN: | 1557-3265 |
| Online-Zugang: | Verlag: https://aacrjournals.org/clincancerres/article/4/2/343/12694/Dissemination-of-tumor-cells-in-patients?searchresult=1
|
| Verfasserangaben: | Jürgen Weitz, Peter Kienle, Jeannine Lacroix, Frank Willeke, Axel Benner, Thomas Lehnert, Christian Herfarth, Magnus von Knebel Doeberitz |
MARC
| LEADER | 00000naa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1937492834 | ||
| 003 | DE-627 | ||
| 005 | 20251001105559.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 251001s1998 xx |||||o 00| ||eng c | ||
| 035 | |a (DE-627)1937492834 | ||
| 035 | |a (DE-599)KXP1937492834 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Weitz, Jürgen |e VerfasserIn |0 (DE-588)1022345974 |0 (DE-627)716954451 |0 (DE-576)171632176 |4 aut | |
| 245 | 1 | 0 | |a Dissemination of tumor cells in patients undergoing surgery for colorectal cancer |c Jürgen Weitz, Peter Kienle, Jeannine Lacroix, Frank Willeke, Axel Benner, Thomas Lehnert, Christian Herfarth, Magnus von Knebel Doeberitz |
| 264 | 1 | |c February 01 1998 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 01.10.2025 | ||
| 520 | |a The majority of patients with colorectal cancer present at a stage when the primary cancer can be resected with curative intent. However, despite the high resectability rate, about 30-50% of these patients subsequently develop metastatic disease. In these patients, neoplastic cells were disseminated either before or during surgery of the primary cancer. Due to the lack of appropriate detection systems, the extent of pre- and intraoperative hematogenic tumor cell dissemination has not yet been determined. Using a reverse transcription-PCR assay to amplify cytokeratin 20 transcripts, we were able to detect 10 colorectal cancer cells in 10 ml of blood. Blood samples were taken from 65 patients undergoing resection of primary colorectal cancer or liver metastasis of colorectal cancer pre-, intra-, and postoperatively. Circulating tumor cells were detected in 24 of 58 patients with colorectal resections in correlation to the tumor stage and in 6 of 7 patients who underwent hemihepatectomy for liver metastasis. In 8 of 58 patients with colorectal resection and in 5 of 7 patients with hemihepatectomy, tumor cells could only be detected during or during and after surgery. These results demonstrate that hematogenic tumor cell dissemination is a frequent and early event in colorectal cancer. Surgery enhances the release of tumor cells into the circulation. The long-term follow-up of our patient cohort will provide data on the prognostic relevance of circulating tumor cells and might lead to new therapeutic concepts for perioperative prophylaxis of tumor cell implantation or postoperative adjuvant therapy regimens. | ||
| 700 | 1 | |a Kienle, Peter |d 1966- |e VerfasserIn |0 (DE-588)1030310262 |0 (DE-627)735023476 |0 (DE-576)378115898 |4 aut | |
| 700 | 1 | |a Lacroix, Jeannine |d 1970- |e VerfasserIn |0 (DE-588)123817080 |0 (DE-627)706436741 |0 (DE-576)293891958 |4 aut | |
| 700 | 1 | |a Willeke, Frank |d 1963- |e VerfasserIn |0 (DE-588)1084359758 |0 (DE-627)848798902 |0 (DE-576)170761568 |4 aut | |
| 700 | 1 | |a Benner, Axel |d 1959- |e VerfasserIn |0 (DE-588)106584686X |0 (DE-627)81687221X |0 (DE-576)425536602 |4 aut | |
| 700 | 1 | |a Lehnert, Thomas |e VerfasserIn |0 (DE-588)1076334229 |0 (DE-627)834714566 |0 (DE-576)445208724 |4 aut | |
| 700 | 1 | |a Herfarth, Christian |d 1933-2014 |e VerfasserIn |0 (DE-588)120706385 |0 (DE-627)080841562 |0 (DE-576)213333414 |4 aut | |
| 700 | 1 | |a Knebel Doeberitz, Magnus von |e VerfasserIn |0 (DE-588)1022165291 |0 (DE-627)71693289X |0 (DE-576)364934239 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Clinical cancer research |d Philadelphia, Pa. [u.a.] : AACR, 1995 |g 4(1998), 2, Seite 343-348 |h Online-Ressource |w (DE-627)325489971 |w (DE-600)2036787-9 |w (DE-576)094502234 |x 1557-3265 |7 nnas |a Dissemination of tumor cells in patients undergoing surgery for colorectal cancer |
| 773 | 1 | 8 | |g volume:4 |g year:1998 |g number:2 |g pages:343-348 |g extent:6 |a Dissemination of tumor cells in patients undergoing surgery for colorectal cancer |
| 856 | 4 | 0 | |u https://aacrjournals.org/clincancerres/article/4/2/343/12694/Dissemination-of-tumor-cells-in-patients?searchresult=1 |x Verlag |
| 951 | |a AR | ||
| 992 | |a 20251001 | ||
| 994 | |a 1998 | ||
| 998 | |g 1022165291 |a Knebel Doeberitz, Magnus von |m 1022165291:Knebel Doeberitz, Magnus von |d 910000 |d 912000 |e 910000PK1022165291 |e 912000PK1022165291 |k 0/910000/ |k 1/910000/912000/ |p 8 |y j | ||
| 998 | |g 120706385 |a Herfarth, Christian |m 120706385:Herfarth, Christian |d 910000 |d 910200 |e 910000PH120706385 |e 910200PH120706385 |k 0/910000/ |k 1/910000/910200/ |p 7 | ||
| 998 | |g 1076334229 |a Lehnert, Thomas |m 1076334229:Lehnert, Thomas |d 910000 |d 910200 |e 910000PL1076334229 |e 910200PL1076334229 |k 0/910000/ |k 1/910000/910200/ |p 6 | ||
| 998 | |g 106584686X |a Benner, Axel |m 106584686X:Benner, Axel |d 50000 |e 50000PB106584686X |k 0/50000/ |p 5 | ||
| 998 | |g 1084359758 |a Willeke, Frank |m 1084359758:Willeke, Frank |d 910000 |d 910200 |e 910000PW1084359758 |e 910200PW1084359758 |k 0/910000/ |k 1/910000/910200/ |p 4 | ||
| 998 | |g 123817080 |a Lacroix, Jeannine |m 123817080:Lacroix, Jeannine |d 50000 |e 50000PL123817080 |k 0/50000/ |p 3 | ||
| 998 | |g 1030310262 |a Kienle, Peter |m 1030310262:Kienle, Peter |d 910000 |d 910200 |e 910000PK1030310262 |e 910200PK1030310262 |k 0/910000/ |k 1/910000/910200/ |p 2 | ||
| 998 | |g 1022345974 |a Weitz, Jürgen |m 1022345974:Weitz, Jürgen |d 910000 |d 910200 |e 910000PW1022345974 |e 910200PW1022345974 |k 0/910000/ |k 1/910000/910200/ |p 1 |x j | ||
| 999 | |a KXP-PPN1937492834 |e 4778522753 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Jürgen Weitz, Peter Kienle, Jeannine Lacroix, Frank Willeke, Axel Benner, Thomas Lehnert, Christian Herfarth, Magnus von Knebel Doeberitz"]},"language":["eng"],"note":["Gesehen am 01.10.2025"],"person":[{"family":"Weitz","role":"aut","given":"Jürgen","display":"Weitz, Jürgen"},{"display":"Kienle, Peter","given":"Peter","role":"aut","family":"Kienle"},{"given":"Jeannine","display":"Lacroix, Jeannine","role":"aut","family":"Lacroix"},{"family":"Willeke","role":"aut","given":"Frank","display":"Willeke, Frank"},{"role":"aut","family":"Benner","display":"Benner, Axel","given":"Axel"},{"given":"Thomas","display":"Lehnert, Thomas","role":"aut","family":"Lehnert"},{"family":"Herfarth","role":"aut","given":"Christian","display":"Herfarth, Christian"},{"family":"Knebel Doeberitz","role":"aut","given":"Magnus von","display":"Knebel Doeberitz, Magnus von"}],"recId":"1937492834","physDesc":[{"extent":"6 S."}],"id":{"eki":["1937492834"]},"title":[{"title":"Dissemination of tumor cells in patients undergoing surgery for colorectal cancer","title_sort":"Dissemination of tumor cells in patients undergoing surgery for colorectal cancer"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedDisp":"February 01 1998","dateIssuedKey":"1998"}],"relHost":[{"disp":"Dissemination of tumor cells in patients undergoing surgery for colorectal cancerClinical cancer research","type":{"media":"Online-Ressource","bibl":"periodical"},"corporate":[{"role":"isb","display":"American Association for Cancer Research"}],"part":{"text":"4(1998), 2, Seite 343-348","pages":"343-348","extent":"6","issue":"2","year":"1998","volume":"4"},"language":["eng"],"note":["Gesehen am 08.06.2023","Fortsetzung der Druck-Ausgabe"],"pubHistory":["1.1995 -"],"id":{"zdb":["2036787-9"],"eki":["325489971"],"issn":["1557-3265"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Clinical cancer research","title_sort":"Clinical cancer research"}],"origin":[{"dateIssuedKey":"1995","publisherPlace":"Philadelphia, Pa. [u.a.]","publisher":"AACR","dateIssuedDisp":"1995-"}],"name":{"displayForm":["American Association for Cancer Research"]},"recId":"325489971"}]} | ||
| SRT | |a WEITZJUERGDISSEMINAT0119 | ||