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Neurocognitive impact of different irradiation modalities for patients with grade I-II skull base meningioma: a prospective multi-arm cohort study (CANCER COG)

Radiotherapy as a complement or an alternative to neurosurgery has a central role in the treatment of skull base grade I-II meningiomas. Radiotherapy techniques have improved considerably over the last two decades, becoming more effective and sparing more and more the healthy tissue surrounding the...

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Main Authors: Lesueur, Paul (Author) , Joly, Florence (Author) , Clarisse, Benedicte (Author) , Lequesne, Justine (Author) , Stefan, Dinu (Author) , Balosso, Jacques (Author) , Lange, Marie (Author) , Thureau, Sebastien (Author) , Capel, Aurelie (Author) , Castera, Marie (Author) , Legrand, Berenice (Author) , Goliot, Nicolas (Author) , Grellard, Jean Michel (Author) , Tessonnier, Thomas (Author) , Castel, Helene (Author) , Valable, Samuel (Author)
Format: Article (Journal)
Language:English
Published: 29 January 2025
In: Radiation oncology
Year: 2025, Volume: 20, Pages: 16-1-16-9
ISSN:1748-717X
DOI:10.1186/s13014-025-02591-1
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13014-025-02591-1
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Author Notes:Paul Lesueur, Florence Joly, Benedicte Clarisse, Justine Lequesne, Dinu Stefan, Jacques Balosso, Marie Lange, Sebastien Thureau, Aurelie Capel, Marie Castera, Berenice Legrand, Nicolas Goliot, Jean Michel Grellard, Thomas Tessonnier, Helene Castel, Samuel Valable

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520 |a Radiotherapy as a complement or an alternative to neurosurgery has a central role in the treatment of skull base grade I-II meningiomas. Radiotherapy techniques have improved considerably over the last two decades, becoming more effective and sparing more and more the healthy tissue surrounding the tumour. Currently, hypo-fractionated stereotactic radiotherapy (SRT) for small tumours and normo-fractionated intensity-modulated radiotherapy (IMRT) or proton-therapy (PT) for larger tumours are the most widely used techniques. It is expected a decrease of the risk of cognitive impairment with these modern techniques. However prospective data about cognitive long-term consequences of partial brain irradiation with SRT, PT, or IMRT remain very scarce to date. 
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